In vivo Firre and Dxz4 deletion elucidates roles for autosomal gene regulation

In vivo Firre and Dxz4 deletion elucidates roles for autosomal gene regulation

Recent evidence has determined that the conserved X chromosome mega-structures controlled by the Firre and Dxz4 loci are not required for X chromosome inactivation (XCI) in cell lines. Here, we examined the in vivo contribution of these loci by generating mice carrying a single or double deletion of...

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Bibliographic Details
Main Authors: Daniel Andergassen, Zachary D Smith, Jordan P Lewandowski, Chiara Gerhardinger, Alexander Meissner, John L Rinn
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-11-01
Series:eLife
Subjects:
X chromosome inactivation
FIRRE
DXZ4
chromosome structure
NHCC
Intra-chromosomal organization
Online Access:https://elifesciences.org/articles/47214

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