Deletion of mdig enhances H3K36me3 and metastatic potential of the triple negative breast cancer cells

Deletion of mdig enhances H3K36me3 and metastatic potential of the triple negative breast cancer cells

Summary: In this report, we provide evidence showing diminished expression of the mineral dust-induced gene (mdig), a previously identified oncogenic gene, in human triple negative breast cancer (TNBC). Using a mouse model of orthotopic xenograft of the TNBC MDA-MB-231 cells, we demonstrate that mdi...

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Bibliographic Details
Main Authors: Chitra Thakur, Yiran Qiu, Qian Zhang, Nicholas J. Carruthers, Miaomiao Yu, Zhuoyue Bi, Yao Fu, Priya Wadgaonkar, Bandar Almutairy, Akimasa Seno, Paul M. Stemmer, Fei Chen
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:iScience
Subjects:
Molecular biology
Molecular mechanism of gene regulation
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222013293

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