Towards Improving the Outcomes of Multiple Ovulation and Embryo Transfer in Sheep, with Particular Focus on Donor Superovulation
Considerable improvements in sheep multiple ovulation and embryo transfer (MOET)protocols have been made; however, unlike for cattle, MOET is poorly developed in sheep, and thus has not been broadly applicable as a routine procedure. The tightly folded nature of the ewe cervix, the inconsistent ovar...
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| Format: | Article |
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MDPI AG
2022-03-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/9/3/117 |
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| author | Sami Ullah Khan Muhammad Ameen Jamal Yanhua Su Hong-Jiang Wei Yubo Qing Wenmin Cheng |
| author_facet | Sami Ullah Khan Muhammad Ameen Jamal Yanhua Su Hong-Jiang Wei Yubo Qing Wenmin Cheng |
| author_sort | Sami Ullah Khan |
| collection | DOAJ |
| description | Considerable improvements in sheep multiple ovulation and embryo transfer (MOET)protocols have been made; however, unlike for cattle, MOET is poorly developed in sheep, and thus has not been broadly applicable as a routine procedure. The tightly folded nature of the ewe cervix, the inconsistent ovarian response to various superovulatory treatments, and the requirement of labor to handle animals, particularly during large-scale production, has limited the implementation of successful MOET in sheep. Moreover, several extrinsic factors (e.g., sources, the purity of gonadotrophins and their administration) and intrinsic factors (e.g., breed, age, nutrition, reproductive status) severely limit the practicability of MOET in sheep and other domestic animals. In this review, we summarize the effects of different superovulatory protocols, and their respective ovarian responses, in terms of ovulation rate, and embryo recovery and transfer. Furthermore, various strategies, such as inhibin immunization, conventional superovulation protocols, and melatonin implants for improving the ovarian response, are discussed in detail. Other reproductive techniques and their relative advantages and disadvantages, such as artificial insemination (AI), and donor embryo recovery and transfer to the recipient through different procedures, which must be taken into consideration for achieving satisfactory results during any MOET program in sheep, are also summarized in this article. |
| first_indexed | 2024-03-09T12:17:29Z |
| format | Article |
| id | doaj.art-1c3072e2246e4d9e916e293a18057076 |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-09T12:17:29Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-1c3072e2246e4d9e916e293a180570762023-11-30T22:44:23ZengMDPI AGVeterinary Sciences2306-73812022-03-019311710.3390/vetsci9030117Towards Improving the Outcomes of Multiple Ovulation and Embryo Transfer in Sheep, with Particular Focus on Donor SuperovulationSami Ullah Khan0Muhammad Ameen Jamal1Yanhua Su2Hong-Jiang Wei3Yubo Qing4Wenmin Cheng5Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, ChinaFaculty of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, ChinaYunnan Key Laboratory of Porcine Gene Editing and Xenotransplantation, Yunnan Agricultural University, Kunming 650201, ChinaYunnan Key Laboratory of Porcine Gene Editing and Xenotransplantation, Yunnan Agricultural University, Kunming 650201, ChinaYunnan Key Laboratory of Porcine Gene Editing and Xenotransplantation, Yunnan Agricultural University, Kunming 650201, ChinaFaculty of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, ChinaConsiderable improvements in sheep multiple ovulation and embryo transfer (MOET)protocols have been made; however, unlike for cattle, MOET is poorly developed in sheep, and thus has not been broadly applicable as a routine procedure. The tightly folded nature of the ewe cervix, the inconsistent ovarian response to various superovulatory treatments, and the requirement of labor to handle animals, particularly during large-scale production, has limited the implementation of successful MOET in sheep. Moreover, several extrinsic factors (e.g., sources, the purity of gonadotrophins and their administration) and intrinsic factors (e.g., breed, age, nutrition, reproductive status) severely limit the practicability of MOET in sheep and other domestic animals. In this review, we summarize the effects of different superovulatory protocols, and their respective ovarian responses, in terms of ovulation rate, and embryo recovery and transfer. Furthermore, various strategies, such as inhibin immunization, conventional superovulation protocols, and melatonin implants for improving the ovarian response, are discussed in detail. Other reproductive techniques and their relative advantages and disadvantages, such as artificial insemination (AI), and donor embryo recovery and transfer to the recipient through different procedures, which must be taken into consideration for achieving satisfactory results during any MOET program in sheep, are also summarized in this article.https://www.mdpi.com/2306-7381/9/3/117hormonal protocolsintrinsic and extrinsic factorsembryo recovery and transferovine |
| spellingShingle | Sami Ullah Khan Muhammad Ameen Jamal Yanhua Su Hong-Jiang Wei Yubo Qing Wenmin Cheng Towards Improving the Outcomes of Multiple Ovulation and Embryo Transfer in Sheep, with Particular Focus on Donor Superovulation Veterinary Sciences hormonal protocols intrinsic and extrinsic factors embryo recovery and transfer ovine |
| title | Towards Improving the Outcomes of Multiple Ovulation and Embryo Transfer in Sheep, with Particular Focus on Donor Superovulation |
| title_full | Towards Improving the Outcomes of Multiple Ovulation and Embryo Transfer in Sheep, with Particular Focus on Donor Superovulation |
| title_fullStr | Towards Improving the Outcomes of Multiple Ovulation and Embryo Transfer in Sheep, with Particular Focus on Donor Superovulation |
| title_full_unstemmed | Towards Improving the Outcomes of Multiple Ovulation and Embryo Transfer in Sheep, with Particular Focus on Donor Superovulation |
| title_short | Towards Improving the Outcomes of Multiple Ovulation and Embryo Transfer in Sheep, with Particular Focus on Donor Superovulation |
| title_sort | towards improving the outcomes of multiple ovulation and embryo transfer in sheep with particular focus on donor superovulation |
| topic | hormonal protocols intrinsic and extrinsic factors embryo recovery and transfer ovine |
| url | https://www.mdpi.com/2306-7381/9/3/117 |
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