Evaluating the effects of brain injury, disease and tasks on cognitive fatigue
Abstract Because cognitive fatigue (CF) is common and debilitating following brain injury or disease we investigated the relationships among CF, behavioral performance, and cerebral activation within and across populations by combining the data from two cross-sectional studies. Individuals with mult...
| প্রধান লেখক: | , , , , , , |
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| বিন্যাস: | প্রবন্ধ |
| ভাষা: | English |
| প্রকাশিত: |
Nature Portfolio
2023-11-01
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| মালা: | Scientific Reports |
| অনলাইন ব্যবহার করুন: | https://doi.org/10.1038/s41598-023-46918-y |
| _version_ | 1827711585897938944 |
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| author | Glenn R. Wylie Helen M. Genova Bing Yao Nancy Chiaravalloti Cristina A. F. Román Brian M. Sandroff John DeLuca |
| author_facet | Glenn R. Wylie Helen M. Genova Bing Yao Nancy Chiaravalloti Cristina A. F. Román Brian M. Sandroff John DeLuca |
| author_sort | Glenn R. Wylie |
| collection | DOAJ |
| description | Abstract Because cognitive fatigue (CF) is common and debilitating following brain injury or disease we investigated the relationships among CF, behavioral performance, and cerebral activation within and across populations by combining the data from two cross-sectional studies. Individuals with multiple sclerosis (MS) were included to model CF resulting from neurological disease; individuals who had sustained a traumatic brain injury (TBI) were included to model CF resulting from neurological insult; both groups were compared with a control group (Controls). CF was induced while neuroimaging data was acquired using two different tasks. CF significantly differed between the groups, with the clinical groups reporting more CF than Controls—a difference that was statistically significant for the TBI group and trended towards significance for the MS group. The accrual of CF did not differ across the three groups; and CF ratings were consistent across tasks. Increasing CF was associated with longer response time for all groups. The brain activation in the caudate nucleus and the thalamus was consistently correlated with CF in all three groups, while more dorsally in the caudate, activation differed across the groups. These results suggest the caudate and thalamus to be central to CF while more dorsal aspects of the caudate may be sensitive to damage associated with particular types of insult. |
| first_indexed | 2024-03-10T17:56:41Z |
| format | Article |
| id | doaj.art-1c30b986134943d6b69d27838f16ea35 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T17:56:41Z |
| publishDate | 2023-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-1c30b986134943d6b69d27838f16ea352023-11-20T09:09:03ZengNature PortfolioScientific Reports2045-23222023-11-0113111110.1038/s41598-023-46918-yEvaluating the effects of brain injury, disease and tasks on cognitive fatigueGlenn R. Wylie0Helen M. Genova1Bing Yao2Nancy Chiaravalloti3Cristina A. F. Román4Brian M. Sandroff5John DeLuca6Rocco Ortenzio Neuroimaging Center, Kessler FoundationRocco Ortenzio Neuroimaging Center, Kessler FoundationRocco Ortenzio Neuroimaging Center, Kessler FoundationRocco Ortenzio Neuroimaging Center, Kessler FoundationRocco Ortenzio Neuroimaging Center, Kessler FoundationRocco Ortenzio Neuroimaging Center, Kessler FoundationRocco Ortenzio Neuroimaging Center, Kessler FoundationAbstract Because cognitive fatigue (CF) is common and debilitating following brain injury or disease we investigated the relationships among CF, behavioral performance, and cerebral activation within and across populations by combining the data from two cross-sectional studies. Individuals with multiple sclerosis (MS) were included to model CF resulting from neurological disease; individuals who had sustained a traumatic brain injury (TBI) were included to model CF resulting from neurological insult; both groups were compared with a control group (Controls). CF was induced while neuroimaging data was acquired using two different tasks. CF significantly differed between the groups, with the clinical groups reporting more CF than Controls—a difference that was statistically significant for the TBI group and trended towards significance for the MS group. The accrual of CF did not differ across the three groups; and CF ratings were consistent across tasks. Increasing CF was associated with longer response time for all groups. The brain activation in the caudate nucleus and the thalamus was consistently correlated with CF in all three groups, while more dorsally in the caudate, activation differed across the groups. These results suggest the caudate and thalamus to be central to CF while more dorsal aspects of the caudate may be sensitive to damage associated with particular types of insult.https://doi.org/10.1038/s41598-023-46918-y |
| spellingShingle | Glenn R. Wylie Helen M. Genova Bing Yao Nancy Chiaravalloti Cristina A. F. Román Brian M. Sandroff John DeLuca Evaluating the effects of brain injury, disease and tasks on cognitive fatigue Scientific Reports |
| title | Evaluating the effects of brain injury, disease and tasks on cognitive fatigue |
| title_full | Evaluating the effects of brain injury, disease and tasks on cognitive fatigue |
| title_fullStr | Evaluating the effects of brain injury, disease and tasks on cognitive fatigue |
| title_full_unstemmed | Evaluating the effects of brain injury, disease and tasks on cognitive fatigue |
| title_short | Evaluating the effects of brain injury, disease and tasks on cognitive fatigue |
| title_sort | evaluating the effects of brain injury disease and tasks on cognitive fatigue |
| url | https://doi.org/10.1038/s41598-023-46918-y |
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