Uterine choriocarcinoma coexistence with endometroid adenocacinoma: a case report and literature review
Abstract Background Choriocarcinoma coexisting with endometrial carcinoma is rare. To the best of our knowledge, only one case of choriocarcinoma coexisting with endometrial carcinoma has been reported. Case presentation Here, we present this case and provide a literature review. A 38-year-old unmar...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | BMC Women's Health |
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| Online Access: | https://doi.org/10.1186/s12905-023-02377-1 |
| _version_ | 1797827356926148608 |
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| author | Liping Bai Yali Chen Ling Han Ai Zheng Xiaoyu Mo |
| author_facet | Liping Bai Yali Chen Ling Han Ai Zheng Xiaoyu Mo |
| author_sort | Liping Bai |
| collection | DOAJ |
| description | Abstract Background Choriocarcinoma coexisting with endometrial carcinoma is rare. To the best of our knowledge, only one case of choriocarcinoma coexisting with endometrial carcinoma has been reported. Case presentation Here, we present this case and provide a literature review. A 38-year-old unmarried nulliparous woman presented to the clinic with a menstrual disorder for more than 3 months. She then underwent a hysteroscopic procedure. The pathological findings were malignant, two types of carcinoma, and no transitional lesions were observed; about 85% of them were choriocarcinoma with smooth muscle infiltration and intravascular investigation of the thrombus; about 15% were highly differentiated endometrioid adenocarcinoma; Immunohistochemistry (endometrioid/choriocarcinoma): Vim (+ + / + + +), P40 (+ ±), CK5/6 multifocal ( ±), CK7 ( ±), EMA (+ ±), P16 multifocal ( ±), P53 (+ / + +), WT-1 (-/ + +), hCG (-/ + + +), CD138 (-/ + + +), Gly-3 (-/-), ER ( ±), PR (+ ±), Sall-4 (-/-), P21 (-/ +), P27 (-/ + + +), CyclinE (-/ + +), Ki67 positivity rate (10%/95%). We performed a laparoscopic hysterectomy, bilateral adnexectomy, and pelvic and para-abdominal lymph node dissection after five cycles of chemotherapy. She was diagnosed with choriocarcinoma with endometrial cancer, stage IVb choriocarcinoma and stage IA endometrial cancer. Postoperative radiochemotherapy was administered. The patient was disease-free 40 months after the treatment ended. Conclusion We report a case of choriocarcinoma coexisting with endometrial carcinoma and provide a literature review that may help inspire additional studies in the future. |
| first_indexed | 2024-04-09T12:46:59Z |
| format | Article |
| id | doaj.art-1c318adee17142e1946d2ed8c4913949 |
| institution | Directory Open Access Journal |
| issn | 1472-6874 |
| language | English |
| last_indexed | 2024-04-09T12:46:59Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Women's Health |
| spelling | doaj.art-1c318adee17142e1946d2ed8c49139492023-05-14T11:26:18ZengBMCBMC Women's Health1472-68742023-05-012311610.1186/s12905-023-02377-1Uterine choriocarcinoma coexistence with endometroid adenocacinoma: a case report and literature reviewLiping Bai0Yali Chen1Ling Han2Ai Zheng3Xiaoyu Mo4Department of Gynaecology and Obstetrics, West China Second Hospital, Sichuan UniversityDepartment of Gynaecology and Obstetrics, West China Second Hospital, Sichuan UniversityDepartment of Gynaecology and Obstetrics, West China Second Hospital, Sichuan UniversityDepartment of Gynaecology and Obstetrics, West China Second Hospital, Sichuan UniversityDepartment of Gynaecology and Obstetrics, West China Second Hospital, Sichuan UniversityAbstract Background Choriocarcinoma coexisting with endometrial carcinoma is rare. To the best of our knowledge, only one case of choriocarcinoma coexisting with endometrial carcinoma has been reported. Case presentation Here, we present this case and provide a literature review. A 38-year-old unmarried nulliparous woman presented to the clinic with a menstrual disorder for more than 3 months. She then underwent a hysteroscopic procedure. The pathological findings were malignant, two types of carcinoma, and no transitional lesions were observed; about 85% of them were choriocarcinoma with smooth muscle infiltration and intravascular investigation of the thrombus; about 15% were highly differentiated endometrioid adenocarcinoma; Immunohistochemistry (endometrioid/choriocarcinoma): Vim (+ + / + + +), P40 (+ ±), CK5/6 multifocal ( ±), CK7 ( ±), EMA (+ ±), P16 multifocal ( ±), P53 (+ / + +), WT-1 (-/ + +), hCG (-/ + + +), CD138 (-/ + + +), Gly-3 (-/-), ER ( ±), PR (+ ±), Sall-4 (-/-), P21 (-/ +), P27 (-/ + + +), CyclinE (-/ + +), Ki67 positivity rate (10%/95%). We performed a laparoscopic hysterectomy, bilateral adnexectomy, and pelvic and para-abdominal lymph node dissection after five cycles of chemotherapy. She was diagnosed with choriocarcinoma with endometrial cancer, stage IVb choriocarcinoma and stage IA endometrial cancer. Postoperative radiochemotherapy was administered. The patient was disease-free 40 months after the treatment ended. Conclusion We report a case of choriocarcinoma coexisting with endometrial carcinoma and provide a literature review that may help inspire additional studies in the future.https://doi.org/10.1186/s12905-023-02377-1ChoriocarcinomaEndometrial carcinomaCoexistCase report |
| spellingShingle | Liping Bai Yali Chen Ling Han Ai Zheng Xiaoyu Mo Uterine choriocarcinoma coexistence with endometroid adenocacinoma: a case report and literature review BMC Women's Health Choriocarcinoma Endometrial carcinoma Coexist Case report |
| title | Uterine choriocarcinoma coexistence with endometroid adenocacinoma: a case report and literature review |
| title_full | Uterine choriocarcinoma coexistence with endometroid adenocacinoma: a case report and literature review |
| title_fullStr | Uterine choriocarcinoma coexistence with endometroid adenocacinoma: a case report and literature review |
| title_full_unstemmed | Uterine choriocarcinoma coexistence with endometroid adenocacinoma: a case report and literature review |
| title_short | Uterine choriocarcinoma coexistence with endometroid adenocacinoma: a case report and literature review |
| title_sort | uterine choriocarcinoma coexistence with endometroid adenocacinoma a case report and literature review |
| topic | Choriocarcinoma Endometrial carcinoma Coexist Case report |
| url | https://doi.org/10.1186/s12905-023-02377-1 |
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