Systemic inflammatory markers and EEG features of children with FIRES receiving anakinra
Abstract In a retrospective case series of 10 children with cryptogenic FIRES, we sought to describe the early clinical course and potential biomarkers following anakinra initiation. Six children achieved anesthetic withdrawal within 3 weeks of therapy and one in week four. Of the available cEEG (si...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-03-01
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| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.51714 |
| _version_ | 1827971502155235328 |
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| author | Yi‐Chen Lai Gabriella Abou‐El‐Kheir Thao Nguyen Margo Hanerhoff James J. Riviello Eyal Muscal |
| author_facet | Yi‐Chen Lai Gabriella Abou‐El‐Kheir Thao Nguyen Margo Hanerhoff James J. Riviello Eyal Muscal |
| author_sort | Yi‐Chen Lai |
| collection | DOAJ |
| description | Abstract In a retrospective case series of 10 children with cryptogenic FIRES, we sought to describe the early clinical course and potential biomarkers following anakinra initiation. Six children achieved anesthetic withdrawal within 3 weeks of therapy and one in week four. Of the available cEEG (six children), CRP (10 children), and serum cytokine (six children) studies, there were temporal changes in highly epileptiform bursts (observed in three children), CRP, IL‐6, and IL‐10 levels that might parallel clinical progression. These observations may represent candidate biomarkers for monitoring clinical progression and therapeutic interventions including anakinra, which merits further investigation in future studies. |
| first_indexed | 2024-04-09T19:09:57Z |
| format | Article |
| id | doaj.art-1c348a0f80ea4714887d3daf1ff8770b |
| institution | Directory Open Access Journal |
| issn | 2328-9503 |
| language | English |
| last_indexed | 2024-04-09T19:09:57Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj.art-1c348a0f80ea4714887d3daf1ff8770b2023-04-06T17:45:38ZengWileyAnnals of Clinical and Translational Neurology2328-95032023-03-0110344044610.1002/acn3.51714Systemic inflammatory markers and EEG features of children with FIRES receiving anakinraYi‐Chen Lai0Gabriella Abou‐El‐Kheir1Thao Nguyen2Margo Hanerhoff3James J. Riviello4Eyal Muscal5Division of Pediatric Critical Care Medicine Baylor College of Medicine Houston Texas USADivision of Pediatric Critical Care Medicine Baylor College of Medicine Houston Texas USADivision of Pediatric Critical Care Medicine Baylor College of Medicine Houston Texas USATexas Children's Hospital Houston Texas USADivision of Neurology and Developmental Neuroscience, Department of Pediatrics Baylor College of Medicine Houston Texas USADivision of Neurology and Developmental Neuroscience, Department of Pediatrics Baylor College of Medicine Houston Texas USAAbstract In a retrospective case series of 10 children with cryptogenic FIRES, we sought to describe the early clinical course and potential biomarkers following anakinra initiation. Six children achieved anesthetic withdrawal within 3 weeks of therapy and one in week four. Of the available cEEG (six children), CRP (10 children), and serum cytokine (six children) studies, there were temporal changes in highly epileptiform bursts (observed in three children), CRP, IL‐6, and IL‐10 levels that might parallel clinical progression. These observations may represent candidate biomarkers for monitoring clinical progression and therapeutic interventions including anakinra, which merits further investigation in future studies.https://doi.org/10.1002/acn3.51714 |
| spellingShingle | Yi‐Chen Lai Gabriella Abou‐El‐Kheir Thao Nguyen Margo Hanerhoff James J. Riviello Eyal Muscal Systemic inflammatory markers and EEG features of children with FIRES receiving anakinra Annals of Clinical and Translational Neurology |
| title | Systemic inflammatory markers and EEG features of children with FIRES receiving anakinra |
| title_full | Systemic inflammatory markers and EEG features of children with FIRES receiving anakinra |
| title_fullStr | Systemic inflammatory markers and EEG features of children with FIRES receiving anakinra |
| title_full_unstemmed | Systemic inflammatory markers and EEG features of children with FIRES receiving anakinra |
| title_short | Systemic inflammatory markers and EEG features of children with FIRES receiving anakinra |
| title_sort | systemic inflammatory markers and eeg features of children with fires receiving anakinra |
| url | https://doi.org/10.1002/acn3.51714 |
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