Synthesis, Reactivity Studies, and Cytotoxicity of Two <i>trans</i>-Iodidoplatinum(II) Complexes. Does Photoactivation Work?
<i>trans</i>-Platinum complexes have been the landmark in unconventional drugs prompting the development of innovative structures that might exhibit chemical and biological profiles different to cisplatin. Iodido complexes signaled a new turning point in the platinum drug design field wh...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-12-01
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| Series: | Inorganics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2304-6740/6/4/127 |
| _version_ | 1811273835857575936 |
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| author | Leticia Cubo Thalia Parro Amancio Carnero Luca Salassa Ana I. Matesanz Adoracion G. Quiroga |
| author_facet | Leticia Cubo Thalia Parro Amancio Carnero Luca Salassa Ana I. Matesanz Adoracion G. Quiroga |
| author_sort | Leticia Cubo |
| collection | DOAJ |
| description | <i>trans</i>-Platinum complexes have been the landmark in unconventional drugs prompting the development of innovative structures that might exhibit chemical and biological profiles different to cisplatin. Iodido complexes signaled a new turning point in the platinum drug design field when their cytotoxicity was reevaluated and reported. In this new study, we have synthesized and evaluated diodidoplatinum complexes <i>trans</i>-[PtI<sub>2</sub>(amine)(pyridine)] bearing aliphatic amines (isopropylamine and methylamine) and pyridines in <i>trans</i> configuration. X-ray diffraction data support the structural characterization. Their cytotoxicity has been evaluated in tumor cell lines such as SAOS-2, A375, T-47D, and HCT116. Moreover, we report their solution behavior and reactivity with biological models. Ultraviolet-a (UVA) irradiation induces an increase in their reactivity towards model nucleobase 5′-GMP in early stages, and promotes the release of the pyridine ligand (spectator ligand) at longer reaction times. Density Functional calculations have been performed and the results are compared with our previous studies with other iodido derivatives. |
| first_indexed | 2024-04-12T23:06:37Z |
| format | Article |
| id | doaj.art-1c35e0822f45410a8bfc98604c10f9e6 |
| institution | Directory Open Access Journal |
| issn | 2304-6740 |
| language | English |
| last_indexed | 2024-04-12T23:06:37Z |
| publishDate | 2018-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Inorganics |
| spelling | doaj.art-1c35e0822f45410a8bfc98604c10f9e62022-12-22T03:12:54ZengMDPI AGInorganics2304-67402018-12-016412710.3390/inorganics6040127inorganics6040127Synthesis, Reactivity Studies, and Cytotoxicity of Two <i>trans</i>-Iodidoplatinum(II) Complexes. Does Photoactivation Work?Leticia Cubo0Thalia Parro1Amancio Carnero2Luca Salassa3Ana I. Matesanz4Adoracion G. Quiroga5Departamento de Química Inorgánica, Universidad Autónoma de Madrid, 28049-Madrid, SpainDepartamento de Química Inorgánica, Universidad Autónoma de Madrid, 28049-Madrid, SpainIBIS, Campus Hospital Universitario Virgen del Rocío, 41013-Sevilla, SpainDonostia International Physics Center, 20018-Donostia, SpainDepartamento de Química Inorgánica, Universidad Autónoma de Madrid, 28049-Madrid, SpainDepartamento de Química Inorgánica, Universidad Autónoma de Madrid, 28049-Madrid, Spain<i>trans</i>-Platinum complexes have been the landmark in unconventional drugs prompting the development of innovative structures that might exhibit chemical and biological profiles different to cisplatin. Iodido complexes signaled a new turning point in the platinum drug design field when their cytotoxicity was reevaluated and reported. In this new study, we have synthesized and evaluated diodidoplatinum complexes <i>trans</i>-[PtI<sub>2</sub>(amine)(pyridine)] bearing aliphatic amines (isopropylamine and methylamine) and pyridines in <i>trans</i> configuration. X-ray diffraction data support the structural characterization. Their cytotoxicity has been evaluated in tumor cell lines such as SAOS-2, A375, T-47D, and HCT116. Moreover, we report their solution behavior and reactivity with biological models. Ultraviolet-a (UVA) irradiation induces an increase in their reactivity towards model nucleobase 5′-GMP in early stages, and promotes the release of the pyridine ligand (spectator ligand) at longer reaction times. Density Functional calculations have been performed and the results are compared with our previous studies with other iodido derivatives.https://www.mdpi.com/2304-6740/6/4/127platinum iodido complexescytotoxicityphotoactivation |
| spellingShingle | Leticia Cubo Thalia Parro Amancio Carnero Luca Salassa Ana I. Matesanz Adoracion G. Quiroga Synthesis, Reactivity Studies, and Cytotoxicity of Two <i>trans</i>-Iodidoplatinum(II) Complexes. Does Photoactivation Work? Inorganics platinum iodido complexes cytotoxicity photoactivation |
| title | Synthesis, Reactivity Studies, and Cytotoxicity of Two <i>trans</i>-Iodidoplatinum(II) Complexes. Does Photoactivation Work? |
| title_full | Synthesis, Reactivity Studies, and Cytotoxicity of Two <i>trans</i>-Iodidoplatinum(II) Complexes. Does Photoactivation Work? |
| title_fullStr | Synthesis, Reactivity Studies, and Cytotoxicity of Two <i>trans</i>-Iodidoplatinum(II) Complexes. Does Photoactivation Work? |
| title_full_unstemmed | Synthesis, Reactivity Studies, and Cytotoxicity of Two <i>trans</i>-Iodidoplatinum(II) Complexes. Does Photoactivation Work? |
| title_short | Synthesis, Reactivity Studies, and Cytotoxicity of Two <i>trans</i>-Iodidoplatinum(II) Complexes. Does Photoactivation Work? |
| title_sort | synthesis reactivity studies and cytotoxicity of two i trans i iodidoplatinum ii complexes does photoactivation work |
| topic | platinum iodido complexes cytotoxicity photoactivation |
| url | https://www.mdpi.com/2304-6740/6/4/127 |
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