Nano Zinc-Enabled Strategies in Crops for Combatting Zinc Malnutrition in Human Health
Deficits in the mineral Zn are responsible for a sizable proportion of the world’s disease burden and child mortality. With the increasing success rate of biofortification in major crops, the development of a genotype with enhanced Zn bioavailability will be an efficient and sustainable solution to...
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| Format: | Article |
| Language: | English |
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IMR Press
2023-08-01
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| Series: | Frontiers in Bioscience-Landmark |
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| Online Access: | https://www.imrpress.com/journal/FBL/28/8/10.31083/j.fbl2808158 |
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| author | Abhishek Singh Vishnu D. Rajput Divya Pandey Ragini Sharma Karen Ghazaryan Tatiana Minkina |
| author_facet | Abhishek Singh Vishnu D. Rajput Divya Pandey Ragini Sharma Karen Ghazaryan Tatiana Minkina |
| author_sort | Abhishek Singh |
| collection | DOAJ |
| description | Deficits in the mineral Zn are responsible for a sizable proportion of the world’s disease burden and child mortality. With the increasing success rate of biofortification in major crops, the development of a genotype with enhanced Zn bioavailability will be an efficient and sustainable solution to nutrient deficiency-related problems. Due to the complex chemistry of the human system, the absorption of Zn from cereals is lower. This complexity is alleviated by phytate, a major phosphorus-storing compound in cereal and legume seeds, which negatively affects Zn binding. The results of recent studies on the distribution of elements and micronutrient speciation in seeds provide strong evidence for the presence of distinct Zn pools. This observation is supported by data from biofortified transgenic plant research. Several studies identify nicotinamide, a metal chelator, as a pivotal molecule. The loading of Zn into grains has been reported to increase with nicotinamide levels, which is a crucial finding. Intestinal Zn absorption can be greatly improved by nicotinamide. Furthermore, bioavailability tests suggest that the use of nano Zn-enabled devices could be an effective strategy to enable plant biofortification, which may significantly boost the Zn content in various cereal crops. This review comprehensively evaluated the scientific publications indexed in WoS, Scopus, and various other reliable databases and explored insights into how nano-enabled technology could be a solution for enhancing Zn content in cereal crops for combating malnutrition in humans. |
| first_indexed | 2024-03-12T02:39:02Z |
| format | Article |
| id | doaj.art-1c35e21d1d8c4919b92d241ac363a853 |
| institution | Directory Open Access Journal |
| issn | 2768-6701 |
| language | English |
| last_indexed | 2024-03-12T02:39:02Z |
| publishDate | 2023-08-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj.art-1c35e21d1d8c4919b92d241ac363a8532023-09-04T09:13:42ZengIMR PressFrontiers in Bioscience-Landmark2768-67012023-08-0128815810.31083/j.fbl2808158S2768-6701(23)00951-6Nano Zinc-Enabled Strategies in Crops for Combatting Zinc Malnutrition in Human HealthAbhishek Singh0Vishnu D. Rajput1Divya Pandey2Ragini Sharma3Karen Ghazaryan4Tatiana Minkina5Faculty of Biology, Yerevan State University, 0025 Yerevan, ArmeniaAcademy of Biology and Biotechnology, Southern Federal University, 344058 Rostov-on-Don, RussiaDepartment of Fruit Science, Dr YS Parmar University of Horticulture and Forestry, 173230 Solan, Himachal Pradesh, IndiaDepartment of Zoology, Panjab Agriculture University, 141027 Ludhiana, Punjab, IndiaFaculty of Biology, Yerevan State University, 0025 Yerevan, ArmeniaAcademy of Biology and Biotechnology, Southern Federal University, 344058 Rostov-on-Don, RussiaDeficits in the mineral Zn are responsible for a sizable proportion of the world’s disease burden and child mortality. With the increasing success rate of biofortification in major crops, the development of a genotype with enhanced Zn bioavailability will be an efficient and sustainable solution to nutrient deficiency-related problems. Due to the complex chemistry of the human system, the absorption of Zn from cereals is lower. This complexity is alleviated by phytate, a major phosphorus-storing compound in cereal and legume seeds, which negatively affects Zn binding. The results of recent studies on the distribution of elements and micronutrient speciation in seeds provide strong evidence for the presence of distinct Zn pools. This observation is supported by data from biofortified transgenic plant research. Several studies identify nicotinamide, a metal chelator, as a pivotal molecule. The loading of Zn into grains has been reported to increase with nicotinamide levels, which is a crucial finding. Intestinal Zn absorption can be greatly improved by nicotinamide. Furthermore, bioavailability tests suggest that the use of nano Zn-enabled devices could be an effective strategy to enable plant biofortification, which may significantly boost the Zn content in various cereal crops. This review comprehensively evaluated the scientific publications indexed in WoS, Scopus, and various other reliable databases and explored insights into how nano-enabled technology could be a solution for enhancing Zn content in cereal crops for combating malnutrition in humans.https://www.imrpress.com/journal/FBL/28/8/10.31083/j.fbl2808158zincnutrient deficiencynano zinc-enablednicotianaminecereal crops |
| spellingShingle | Abhishek Singh Vishnu D. Rajput Divya Pandey Ragini Sharma Karen Ghazaryan Tatiana Minkina Nano Zinc-Enabled Strategies in Crops for Combatting Zinc Malnutrition in Human Health Frontiers in Bioscience-Landmark zinc nutrient deficiency nano zinc-enabled nicotianamine cereal crops |
| title | Nano Zinc-Enabled Strategies in Crops for Combatting Zinc Malnutrition in Human Health |
| title_full | Nano Zinc-Enabled Strategies in Crops for Combatting Zinc Malnutrition in Human Health |
| title_fullStr | Nano Zinc-Enabled Strategies in Crops for Combatting Zinc Malnutrition in Human Health |
| title_full_unstemmed | Nano Zinc-Enabled Strategies in Crops for Combatting Zinc Malnutrition in Human Health |
| title_short | Nano Zinc-Enabled Strategies in Crops for Combatting Zinc Malnutrition in Human Health |
| title_sort | nano zinc enabled strategies in crops for combatting zinc malnutrition in human health |
| topic | zinc nutrient deficiency nano zinc-enabled nicotianamine cereal crops |
| url | https://www.imrpress.com/journal/FBL/28/8/10.31083/j.fbl2808158 |
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