DNA Binding and Cleavage, Stopped-Flow Kinetic, Mechanistic, and Molecular Docking Studies of Cationic Ruthenium(II) Nitrosyl Complexes Containing “NS<sub>4</sub>” Core

DNA Binding and Cleavage, Stopped-Flow Kinetic, Mechanistic, and Molecular Docking Studies of Cationic Ruthenium(II) Nitrosyl Complexes Containing “NS<sub>4</sub>” Core

This work aimed to evaluate in vitro DNA binding mechanistically of cationic nitrosyl ruthenium complex [RuNOTSP]<sup>+</sup> and its ligand (TSPH<sub>2</sub>) in detail, correlate the findings with cleavage activity, and draw conclusions about the impact of the metal center....

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Bibliographic Details
Main Authors: Hadeer A. Shereef, Yasmine S. Moemen, Fawzia I. Elshami, Ahmed M. El-Nahas, Shaban Y. Shaban, Rudi van Eldik
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Molecules
Subjects:
DNA
ruthenium nitrosyl complexes
reaction mechanism
binding interaction
molecular docking
kinetic investigation
Online Access:https://www.mdpi.com/1420-3049/28/7/3028

Internet

https://www.mdpi.com/1420-3049/28/7/3028

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