Developmental deprivation-induced perceptual and cortical processing deficits in awake-behaving animals
Sensory deprivation during development induces lifelong changes to central nervous system function that are associated with perceptual impairments. However, the relationship between neural and behavioral deficits is uncertain due to a lack of simultaneous measurements during task performance. Theref...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2018-06-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/33891 |
| _version_ | 1811181376930578432 |
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| author | Justin D Yao Dan H Sanes |
| author_facet | Justin D Yao Dan H Sanes |
| author_sort | Justin D Yao |
| collection | DOAJ |
| description | Sensory deprivation during development induces lifelong changes to central nervous system function that are associated with perceptual impairments. However, the relationship between neural and behavioral deficits is uncertain due to a lack of simultaneous measurements during task performance. Therefore, we telemetrically recorded from auditory cortex neurons in gerbils reared with developmental conductive hearing loss as they performed an auditory task in which rapid fluctuations in amplitude are detected. These data were compared to a measure of auditory brainstem temporal processing from each animal. We found that developmental HL diminished behavioral performance, but did not alter brainstem temporal processing. However, the simultaneous assessment of neural and behavioral processing revealed that perceptual deficits were associated with a degraded cortical population code that could be explained by greater trial-to-trial response variability. Our findings suggest that the perceptual limitations that attend early hearing loss are best explained by an encoding deficit in auditory cortex. |
| first_indexed | 2024-04-11T09:16:47Z |
| format | Article |
| id | doaj.art-1c389a211b1c4c5996de859a018df73f |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:16:47Z |
| publishDate | 2018-06-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-1c389a211b1c4c5996de859a018df73f2022-12-22T04:32:18ZengeLife Sciences Publications LtdeLife2050-084X2018-06-01710.7554/eLife.33891Developmental deprivation-induced perceptual and cortical processing deficits in awake-behaving animalsJustin D Yao0https://orcid.org/0000-0001-8762-9044Dan H Sanes1https://orcid.org/0000-0002-3783-6165Center for Neural Science, New York University, New York, United StatesCenter for Neural Science, New York University, New York, United States; Department of Psychology, New York University, New York, United States; Department of Biology, New York University, New York, United States; Neuroscience Institute, NYU Langone Medical Center, New York, United StatesSensory deprivation during development induces lifelong changes to central nervous system function that are associated with perceptual impairments. However, the relationship between neural and behavioral deficits is uncertain due to a lack of simultaneous measurements during task performance. Therefore, we telemetrically recorded from auditory cortex neurons in gerbils reared with developmental conductive hearing loss as they performed an auditory task in which rapid fluctuations in amplitude are detected. These data were compared to a measure of auditory brainstem temporal processing from each animal. We found that developmental HL diminished behavioral performance, but did not alter brainstem temporal processing. However, the simultaneous assessment of neural and behavioral processing revealed that perceptual deficits were associated with a degraded cortical population code that could be explained by greater trial-to-trial response variability. Our findings suggest that the perceptual limitations that attend early hearing loss are best explained by an encoding deficit in auditory cortex.https://elifesciences.org/articles/33891gerbilcortexbrainstemtemporal processingdevelopmenthearing loss |
| spellingShingle | Justin D Yao Dan H Sanes Developmental deprivation-induced perceptual and cortical processing deficits in awake-behaving animals eLife gerbil cortex brainstem temporal processing development hearing loss |
| title | Developmental deprivation-induced perceptual and cortical processing deficits in awake-behaving animals |
| title_full | Developmental deprivation-induced perceptual and cortical processing deficits in awake-behaving animals |
| title_fullStr | Developmental deprivation-induced perceptual and cortical processing deficits in awake-behaving animals |
| title_full_unstemmed | Developmental deprivation-induced perceptual and cortical processing deficits in awake-behaving animals |
| title_short | Developmental deprivation-induced perceptual and cortical processing deficits in awake-behaving animals |
| title_sort | developmental deprivation induced perceptual and cortical processing deficits in awake behaving animals |
| topic | gerbil cortex brainstem temporal processing development hearing loss |
| url | https://elifesciences.org/articles/33891 |
| work_keys_str_mv | AT justindyao developmentaldeprivationinducedperceptualandcorticalprocessingdeficitsinawakebehavinganimals AT danhsanes developmentaldeprivationinducedperceptualandcorticalprocessingdeficitsinawakebehavinganimals |