Clinical factors associated with stable treatment of chronic constipation in Japanese patients
Abstract Background/Aims Chronic constipation (CC) is one of the most common gastrointestinal disorders in the general population. Although there are many treatment options, achieving a stable treatment for CC remains one of the challenges in clinical practice. This study aimed to evaluate the clini...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-024-03140-y |
| _version_ | 1827327234085486592 |
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| author | Kazuki Ishibashi Yuji Urabe Nhu Thi Hanh Vu Shunsuke Miyauchi Takeo Nakamura Hirona Konishi Junichi Mizuno Motomitsu Fukuhara Hidehiko Takigawa Ryo Yuge Duc Trong Quach Shiro Oka Toru Hiyama |
| author_facet | Kazuki Ishibashi Yuji Urabe Nhu Thi Hanh Vu Shunsuke Miyauchi Takeo Nakamura Hirona Konishi Junichi Mizuno Motomitsu Fukuhara Hidehiko Takigawa Ryo Yuge Duc Trong Quach Shiro Oka Toru Hiyama |
| author_sort | Kazuki Ishibashi |
| collection | DOAJ |
| description | Abstract Background/Aims Chronic constipation (CC) is one of the most common gastrointestinal disorders in the general population. Although there are many treatment options, achieving a stable treatment for CC remains one of the challenges in clinical practice. This study aimed to evaluate the clinical factors associated with stable treatment for CC in Japanese patients. Methods A retrospective, cross-sectional, and multicenter study was carried out. Patients were eligible for inclusion if they fulfilled the Rome IV criteria for diagnosing CC and had been treated for at least one and a half years. Patients with up to two prescription modifications for CC in one year were defined as the stable treatment group, whereas those with three or more prescription changes were defined as the unstable treatment group. Univariate and multivariate analyses were carried out to identify factors associated with CC. Results A total of 114 patients have been recruited. There were 82 patients (77.0%) in the stable treatment group and 32 patients (23.0%) in the unstable treatment group. Based on multivariate likelihood analysis, only using acid-suppressive drugs contributed to stability treatment in CC patients (odds ratio: 2.81, 95% confidence interval: 1.12–7.08, p = 0.03). Conclusion Administration of acid-suppressive drugs was the only factor related to the stability of CC treatment. Further studies are needed to validate the results as well as clarify the causes. |
| first_indexed | 2024-03-07T14:58:09Z |
| format | Article |
| id | doaj.art-1c3921058cd44c50b47c99ec7eb3a2e0 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-03-07T14:58:09Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-1c3921058cd44c50b47c99ec7eb3a2e02024-03-05T19:18:01ZengBMCBMC Gastroenterology1471-230X2024-01-012411610.1186/s12876-024-03140-yClinical factors associated with stable treatment of chronic constipation in Japanese patientsKazuki Ishibashi0Yuji Urabe1Nhu Thi Hanh Vu2Shunsuke Miyauchi3Takeo Nakamura4Hirona Konishi5Junichi Mizuno6Motomitsu Fukuhara7Hidehiko Takigawa8Ryo Yuge9Duc Trong Quach10Shiro Oka11Toru Hiyama12Department of Gastroenterology, Graduate School of Biomedical and Health SciencesDepartment of Gastrointestinal Endoscopy and Medicine, Hiroshima University HospitalDepartment of Internal Medicine, University of Medicine and Pharmacy at Ho Chi Minh CityHealth Service Center, Hiroshima UniversityDepartment of Gastroenterology, Graduate School of Biomedical and Health SciencesDepartment of Gastroenterology, Graduate School of Biomedical and Health SciencesDepartment of Gastroenterology, Graduate School of Biomedical and Health SciencesDepartment of Gastroenterology, Graduate School of Biomedical and Health SciencesDepartment of Gastroenterology, Graduate School of Biomedical and Health SciencesDepartment of Gastroenterology, Graduate School of Biomedical and Health SciencesDepartment of Internal Medicine, University of Medicine and Pharmacy at Ho Chi Minh CityDepartment of Gastroenterology, Graduate School of Biomedical and Health SciencesHealth Service Center, Hiroshima UniversityAbstract Background/Aims Chronic constipation (CC) is one of the most common gastrointestinal disorders in the general population. Although there are many treatment options, achieving a stable treatment for CC remains one of the challenges in clinical practice. This study aimed to evaluate the clinical factors associated with stable treatment for CC in Japanese patients. Methods A retrospective, cross-sectional, and multicenter study was carried out. Patients were eligible for inclusion if they fulfilled the Rome IV criteria for diagnosing CC and had been treated for at least one and a half years. Patients with up to two prescription modifications for CC in one year were defined as the stable treatment group, whereas those with three or more prescription changes were defined as the unstable treatment group. Univariate and multivariate analyses were carried out to identify factors associated with CC. Results A total of 114 patients have been recruited. There were 82 patients (77.0%) in the stable treatment group and 32 patients (23.0%) in the unstable treatment group. Based on multivariate likelihood analysis, only using acid-suppressive drugs contributed to stability treatment in CC patients (odds ratio: 2.81, 95% confidence interval: 1.12–7.08, p = 0.03). Conclusion Administration of acid-suppressive drugs was the only factor related to the stability of CC treatment. Further studies are needed to validate the results as well as clarify the causes.https://doi.org/10.1186/s12876-024-03140-yChronic constipationStable treatmentUnstable treatmentClinical factorAcid-suppressive drugs |
| spellingShingle | Kazuki Ishibashi Yuji Urabe Nhu Thi Hanh Vu Shunsuke Miyauchi Takeo Nakamura Hirona Konishi Junichi Mizuno Motomitsu Fukuhara Hidehiko Takigawa Ryo Yuge Duc Trong Quach Shiro Oka Toru Hiyama Clinical factors associated with stable treatment of chronic constipation in Japanese patients BMC Gastroenterology Chronic constipation Stable treatment Unstable treatment Clinical factor Acid-suppressive drugs |
| title | Clinical factors associated with stable treatment of chronic constipation in Japanese patients |
| title_full | Clinical factors associated with stable treatment of chronic constipation in Japanese patients |
| title_fullStr | Clinical factors associated with stable treatment of chronic constipation in Japanese patients |
| title_full_unstemmed | Clinical factors associated with stable treatment of chronic constipation in Japanese patients |
| title_short | Clinical factors associated with stable treatment of chronic constipation in Japanese patients |
| title_sort | clinical factors associated with stable treatment of chronic constipation in japanese patients |
| topic | Chronic constipation Stable treatment Unstable treatment Clinical factor Acid-suppressive drugs |
| url | https://doi.org/10.1186/s12876-024-03140-y |
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