The Effect of Narrow-Band Ultraviolet B Phototherapy on Free and Total Vitamin D Serum Levels in Mild to Severe Plaque Psoriasis
Vitamin D plays an important role in skin inflammation in psoriasis. The beneficial effects of ultraviolet light B (UVB) phototherapy in psoriasis are partly attributed to UVB-induced increase of vitamin D levels. In clinical practice, total 25-hydroxy vitamin D (25(OH)D) levels are measured to asse...
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| Format: | Article |
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MDPI AG
2023-06-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/7/1018 |
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| author | Andrea Elmelid Maria Siekkeri Vandikas Martin Gillstedt Amra Osmancevic Mikael Alsterholm |
| author_facet | Andrea Elmelid Maria Siekkeri Vandikas Martin Gillstedt Amra Osmancevic Mikael Alsterholm |
| author_sort | Andrea Elmelid |
| collection | DOAJ |
| description | Vitamin D plays an important role in skin inflammation in psoriasis. The beneficial effects of ultraviolet light B (UVB) phototherapy in psoriasis are partly attributed to UVB-induced increase of vitamin D levels. In clinical practice, total 25-hydroxy vitamin D (25(OH)D) levels are measured to assess sufficiency, but it might be more accurate to measure free 25(OH)D levels. The aim of this study was to measure free serum 25(OH)D levels in psoriasis patients before and after phototherapy and to investigate if free 25(OH)D correlates stronger to disease severity than total 25(OH)D. Twenty adults (>18 years) with psoriasis were included for treatment with narrow-band UVB (NB-UVB) phototherapy for 10–12 weeks. Psoriasis Area and Severity Index (PASI) and Visual Analogue Scale (VAS) were used to assess disease severity. Serum levels of total 25(OH)D, free 25(OH)D, and 1,25(OH)<sub>2</sub>D were measured before and after NB-UVB. Total 25(OH)D, free 25(OH)D, 1,25(OH)<sub>2</sub>D and the percentage of free 25(OH)D increased after NB-UVB, and PASI and VAS improved. The increase in total and free 25(OH)D remained significant when stratifying for vitamin D confounders. No correlations between disease severity and vitamin D levels were found. Total and free 25(OH)D levels were positively correlated before and after NB-UVB. NB-UVB is an effective treatment for mild to severe plaque psoriasis and increases not only total but also free 25(OH)D levels, as well as the percentage of free 25(OH)D, suggesting an increased bioavailability of skin-produced vitamin D. |
| first_indexed | 2024-03-11T01:15:17Z |
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| id | doaj.art-1c39e2f510f34aaa9c345b2436db18f8 |
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| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T01:15:17Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
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| series | Biomolecules |
| spelling | doaj.art-1c39e2f510f34aaa9c345b2436db18f82023-11-18T18:30:13ZengMDPI AGBiomolecules2218-273X2023-06-01137101810.3390/biom13071018The Effect of Narrow-Band Ultraviolet B Phototherapy on Free and Total Vitamin D Serum Levels in Mild to Severe Plaque PsoriasisAndrea Elmelid0Maria Siekkeri Vandikas1Martin Gillstedt2Amra Osmancevic3Mikael Alsterholm4Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, SwedenDepartment of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, SwedenDepartment of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, SwedenDepartment of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, SwedenDepartment of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, SwedenVitamin D plays an important role in skin inflammation in psoriasis. The beneficial effects of ultraviolet light B (UVB) phototherapy in psoriasis are partly attributed to UVB-induced increase of vitamin D levels. In clinical practice, total 25-hydroxy vitamin D (25(OH)D) levels are measured to assess sufficiency, but it might be more accurate to measure free 25(OH)D levels. The aim of this study was to measure free serum 25(OH)D levels in psoriasis patients before and after phototherapy and to investigate if free 25(OH)D correlates stronger to disease severity than total 25(OH)D. Twenty adults (>18 years) with psoriasis were included for treatment with narrow-band UVB (NB-UVB) phototherapy for 10–12 weeks. Psoriasis Area and Severity Index (PASI) and Visual Analogue Scale (VAS) were used to assess disease severity. Serum levels of total 25(OH)D, free 25(OH)D, and 1,25(OH)<sub>2</sub>D were measured before and after NB-UVB. Total 25(OH)D, free 25(OH)D, 1,25(OH)<sub>2</sub>D and the percentage of free 25(OH)D increased after NB-UVB, and PASI and VAS improved. The increase in total and free 25(OH)D remained significant when stratifying for vitamin D confounders. No correlations between disease severity and vitamin D levels were found. Total and free 25(OH)D levels were positively correlated before and after NB-UVB. NB-UVB is an effective treatment for mild to severe plaque psoriasis and increases not only total but also free 25(OH)D levels, as well as the percentage of free 25(OH)D, suggesting an increased bioavailability of skin-produced vitamin D.https://www.mdpi.com/2218-273X/13/7/1018vitamin Dfree 25-hydroxy vitamin Dpsoriasisphototherapyultraviolet B therapyinflammation |
| spellingShingle | Andrea Elmelid Maria Siekkeri Vandikas Martin Gillstedt Amra Osmancevic Mikael Alsterholm The Effect of Narrow-Band Ultraviolet B Phototherapy on Free and Total Vitamin D Serum Levels in Mild to Severe Plaque Psoriasis Biomolecules vitamin D free 25-hydroxy vitamin D psoriasis phototherapy ultraviolet B therapy inflammation |
| title | The Effect of Narrow-Band Ultraviolet B Phototherapy on Free and Total Vitamin D Serum Levels in Mild to Severe Plaque Psoriasis |
| title_full | The Effect of Narrow-Band Ultraviolet B Phototherapy on Free and Total Vitamin D Serum Levels in Mild to Severe Plaque Psoriasis |
| title_fullStr | The Effect of Narrow-Band Ultraviolet B Phototherapy on Free and Total Vitamin D Serum Levels in Mild to Severe Plaque Psoriasis |
| title_full_unstemmed | The Effect of Narrow-Band Ultraviolet B Phototherapy on Free and Total Vitamin D Serum Levels in Mild to Severe Plaque Psoriasis |
| title_short | The Effect of Narrow-Band Ultraviolet B Phototherapy on Free and Total Vitamin D Serum Levels in Mild to Severe Plaque Psoriasis |
| title_sort | effect of narrow band ultraviolet b phototherapy on free and total vitamin d serum levels in mild to severe plaque psoriasis |
| topic | vitamin D free 25-hydroxy vitamin D psoriasis phototherapy ultraviolet B therapy inflammation |
| url | https://www.mdpi.com/2218-273X/13/7/1018 |
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