Diagnosis and treatment of icteric hepatitis caused by erythropoietic protoporphyria: A case report
Erythropoietic protoporphyria (EPP) is a rare inherited disease caused by partial deficiency activity of the enzyme ferrochelatase (FECH), resulting in excessive accumulation of protoporphyrin IX in erythrocyte and tissues. Here, we report a patient with photosensitive dermatitis and acute icteric h...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2022-06-01
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| Series: | Liver Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2542568422000216 |
| _version_ | 1811238164332806144 |
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| author | Hanqing Huang Leiqin Cai Xinhua Li Shuru Chen |
| author_facet | Hanqing Huang Leiqin Cai Xinhua Li Shuru Chen |
| author_sort | Hanqing Huang |
| collection | DOAJ |
| description | Erythropoietic protoporphyria (EPP) is a rare inherited disease caused by partial deficiency activity of the enzyme ferrochelatase (FECH), resulting in excessive accumulation of protoporphyrin IX in erythrocyte and tissues. Here, we report a patient with photosensitive dermatitis and acute icteric hepatitis caused by EPP, whose clinical and biochemical results successfully improved following 2-month treatment with glucose load, ursodeoxycholic acid capsules, and cholestyramine powder. This case provides a reference for a combination therapy strategy for patients with liver and skin injury caused by EPP. |
| first_indexed | 2024-04-12T12:37:00Z |
| format | Article |
| id | doaj.art-1c3ba72774a64542ac680548e85bb42a |
| institution | Directory Open Access Journal |
| issn | 2542-5684 |
| language | English |
| last_indexed | 2024-04-12T12:37:00Z |
| publishDate | 2022-06-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Liver Research |
| spelling | doaj.art-1c3ba72774a64542ac680548e85bb42a2022-12-22T03:32:52ZengKeAi Communications Co., Ltd.Liver Research2542-56842022-06-0162116120Diagnosis and treatment of icteric hepatitis caused by erythropoietic protoporphyria: A case reportHanqing Huang0Leiqin Cai1Xinhua Li2Shuru Chen3Department of Infectious Diseases and Key Laboratory of Liver Disease of Guangdong Province, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; Department of Gastroenterology, People's Hospital of Longhua District of Shenzhen, Shenzhen, Guangdong, ChinaGuang Dong Clinical Research Center for Metabolic Diseases, Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Infectious Diseases and Key Laboratory of Liver Disease of Guangdong Province, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; Corresponding authors. Department of Infectious Diseases and Key Laboratory of Liver Disease of Guangdong Province, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.Department of Infectious Diseases and Key Laboratory of Liver Disease of Guangdong Province, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; Corresponding authors. Department of Infectious Diseases and Key Laboratory of Liver Disease of Guangdong Province, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.Erythropoietic protoporphyria (EPP) is a rare inherited disease caused by partial deficiency activity of the enzyme ferrochelatase (FECH), resulting in excessive accumulation of protoporphyrin IX in erythrocyte and tissues. Here, we report a patient with photosensitive dermatitis and acute icteric hepatitis caused by EPP, whose clinical and biochemical results successfully improved following 2-month treatment with glucose load, ursodeoxycholic acid capsules, and cholestyramine powder. This case provides a reference for a combination therapy strategy for patients with liver and skin injury caused by EPP.http://www.sciencedirect.com/science/article/pii/S2542568422000216Erythropoietic protoporphyria (EPP)Inherited diseasePhotosensitive dermatitisJaundiceFerrochelatase (FECH)Liver injury |
| spellingShingle | Hanqing Huang Leiqin Cai Xinhua Li Shuru Chen Diagnosis and treatment of icteric hepatitis caused by erythropoietic protoporphyria: A case report Liver Research Erythropoietic protoporphyria (EPP) Inherited disease Photosensitive dermatitis Jaundice Ferrochelatase (FECH) Liver injury |
| title | Diagnosis and treatment of icteric hepatitis caused by erythropoietic protoporphyria: A case report |
| title_full | Diagnosis and treatment of icteric hepatitis caused by erythropoietic protoporphyria: A case report |
| title_fullStr | Diagnosis and treatment of icteric hepatitis caused by erythropoietic protoporphyria: A case report |
| title_full_unstemmed | Diagnosis and treatment of icteric hepatitis caused by erythropoietic protoporphyria: A case report |
| title_short | Diagnosis and treatment of icteric hepatitis caused by erythropoietic protoporphyria: A case report |
| title_sort | diagnosis and treatment of icteric hepatitis caused by erythropoietic protoporphyria a case report |
| topic | Erythropoietic protoporphyria (EPP) Inherited disease Photosensitive dermatitis Jaundice Ferrochelatase (FECH) Liver injury |
| url | http://www.sciencedirect.com/science/article/pii/S2542568422000216 |
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