Novel Bionics Assessment of Anorectal Mechanosensory Physiology
Biomechatronics (bionics) is an applied science that creates interdisciplinary bonds between biology and engineering. The lower gastrointestinal (GI) tract is difficult to study but has gained interest in recent decades from a bionics point of view. Ingestible capsules that record physiological vari...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Bioengineering |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2306-5354/7/4/146 |
| _version_ | 1797547887727476736 |
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| author | Hans Gregersen |
| author_facet | Hans Gregersen |
| author_sort | Hans Gregersen |
| collection | DOAJ |
| description | Biomechatronics (bionics) is an applied science that creates interdisciplinary bonds between biology and engineering. The lower gastrointestinal (GI) tract is difficult to study but has gained interest in recent decades from a bionics point of view. Ingestible capsules that record physiological variables during GI transit have been developed and used for detailed analysis of colon transit and motility. Recently, a simulated stool named Fecobionics was developed. It has the consistency and shape of normal stool. Fecobionics records a variety of parameters including pressures, bending, and shape changes. It has been used to study defecation patterns in large animals and humans, including patients with symptoms of obstructed defecation and fecal incontinence. Recently, it was applied in a canine colon model where it revealed patterns consistent with shallow waves originating from slow waves generated by the interstitial Cells of Cajal. Novel analysis such as the “rear-front” pressure diagram and quantification of defecation indices has been developed for Fecobionics. GI research has traditionally been based on experimental approaches. Mathematical modeling is a unique way to deal with the complexity. This paper describes the Fecobionics technology, related mechano-physiological modeling analyses, and outlines perspectives for future applications. |
| first_indexed | 2024-03-10T14:50:28Z |
| format | Article |
| id | doaj.art-1c3c541bdb6645299e053ab2fe53041d |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-10T14:50:28Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-1c3c541bdb6645299e053ab2fe53041d2023-11-20T20:57:57ZengMDPI AGBioengineering2306-53542020-11-017414610.3390/bioengineering7040146Novel Bionics Assessment of Anorectal Mechanosensory PhysiologyHans Gregersen0The Chinese University of Hong Kong, Shatin, Hong Kong SAR, ChinaBiomechatronics (bionics) is an applied science that creates interdisciplinary bonds between biology and engineering. The lower gastrointestinal (GI) tract is difficult to study but has gained interest in recent decades from a bionics point of view. Ingestible capsules that record physiological variables during GI transit have been developed and used for detailed analysis of colon transit and motility. Recently, a simulated stool named Fecobionics was developed. It has the consistency and shape of normal stool. Fecobionics records a variety of parameters including pressures, bending, and shape changes. It has been used to study defecation patterns in large animals and humans, including patients with symptoms of obstructed defecation and fecal incontinence. Recently, it was applied in a canine colon model where it revealed patterns consistent with shallow waves originating from slow waves generated by the interstitial Cells of Cajal. Novel analysis such as the “rear-front” pressure diagram and quantification of defecation indices has been developed for Fecobionics. GI research has traditionally been based on experimental approaches. Mathematical modeling is a unique way to deal with the complexity. This paper describes the Fecobionics technology, related mechano-physiological modeling analyses, and outlines perspectives for future applications.https://www.mdpi.com/2306-5354/7/4/146anorectal physiologybiomechatronicsbionicscolon transitdefecationFecobionics |
| spellingShingle | Hans Gregersen Novel Bionics Assessment of Anorectal Mechanosensory Physiology Bioengineering anorectal physiology biomechatronics bionics colon transit defecation Fecobionics |
| title | Novel Bionics Assessment of Anorectal Mechanosensory Physiology |
| title_full | Novel Bionics Assessment of Anorectal Mechanosensory Physiology |
| title_fullStr | Novel Bionics Assessment of Anorectal Mechanosensory Physiology |
| title_full_unstemmed | Novel Bionics Assessment of Anorectal Mechanosensory Physiology |
| title_short | Novel Bionics Assessment of Anorectal Mechanosensory Physiology |
| title_sort | novel bionics assessment of anorectal mechanosensory physiology |
| topic | anorectal physiology biomechatronics bionics colon transit defecation Fecobionics |
| url | https://www.mdpi.com/2306-5354/7/4/146 |
| work_keys_str_mv | AT hansgregersen novelbionicsassessmentofanorectalmechanosensoryphysiology |