Correlation of Computed Tomography Parameters with Histology, Stage and Prognosis in Surgically Treated Thymomas
<i>Background and objectives</i>: The histological classification and staging of thymic tumors remains a matter of debate. The correlation of computed tomography (CT) parameters with tumor histology and stage also still has to be completely assessed. The aim of this study was therefore t...
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| Format: | Article |
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MDPI AG
2020-12-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/1/10 |
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| author | Angelo Carretta Stefano Viscardi Piergiorgio Muriana Paola Ciriaco Alessandro Bandiera Roberto Varagona Michele Colombo Giampiero Negri |
| author_facet | Angelo Carretta Stefano Viscardi Piergiorgio Muriana Paola Ciriaco Alessandro Bandiera Roberto Varagona Michele Colombo Giampiero Negri |
| author_sort | Angelo Carretta |
| collection | DOAJ |
| description | <i>Background and objectives</i>: The histological classification and staging of thymic tumors remains a matter of debate. The correlation of computed tomography (CT) parameters with tumor histology and stage also still has to be completely assessed. The aim of this study was therefore to analyze the correlation of radiological parameters with histological and staging classifications of thymomas evaluating their prognostic role. <i>Materials and Methods</i>: Data of 50 patients with thymoma submitted to a complete surgical treatment between 2005 and 2015 were retrospectively analyzed. Tumors were classified according to the WHO and Suster and Moran (S&M) histological classifications and to the Masaoka–Koga and tumor, node and metastases (TNM) staging systems. The correlation of CT features with histology and stage and the prognostic role of histopathological and radiological features were assessed. <i>Results</i>: Five-year overall (OS) and disease-free survival (DFS) were 90.3% and 81.1%, respectively. A significant correlation of DFS with the Masaoka–Koga (<i>p</i> = 0.001) and TNM staging systems (<i>p</i> = 0.002) and with the S&M (<i>p</i> = 0.02) and WHO histological classifications (<i>p</i> = 0.04) was observed. CT scan features correlated with tumor stage, histology and prognosis. Moderately differentiated tumors (WHO B3) had a significantly higher incidence of irregular shape and contours (<i>p</i> = 0.002 and <i>p</i> = 0.001, respectively) and pericardial contact (<i>p</i> = 0.036). A larger tumor volume (<i>p</i> = 0.03) and a greater length of pleural contact (<i>p</i> = 0.04) adversely influenced DFS. The presence of pleural (<i>p</i> < 0.001) or lung invasion (<i>p</i> = 0.02) and of pleural effusion (<i>p</i> = 0.004) was associated with a significantly worse OS. <i>Conclusions</i>: Pre-operative CT scan parameters correlate with stage and histology, and have a prognostic role in surgically treated thymomas. |
| first_indexed | 2024-03-09T22:10:06Z |
| format | Article |
| id | doaj.art-1c3d867af73d4abfb51db7c386970833 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T22:10:06Z |
| publishDate | 2020-12-01 |
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| spelling | doaj.art-1c3d867af73d4abfb51db7c3869708332023-11-23T19:33:50ZengMDPI AGMedicina1010-660X1648-91442020-12-015711010.3390/medicina57010010Correlation of Computed Tomography Parameters with Histology, Stage and Prognosis in Surgically Treated ThymomasAngelo Carretta0Stefano Viscardi1Piergiorgio Muriana2Paola Ciriaco3Alessandro Bandiera4Roberto Varagona5Michele Colombo6Giampiero Negri7Department of Thoracic Surgery, San Raffaele Hospital, Via Olgettina, 60-20132 Milan, ItalyDepartment of Thoracic Surgery, San Raffaele Hospital, Via Olgettina, 60-20132 Milan, ItalyDepartment of Thoracic Surgery, San Raffaele Hospital, Via Olgettina, 60-20132 Milan, ItalyDepartment of Thoracic Surgery, San Raffaele Hospital, Via Olgettina, 60-20132 Milan, ItalyDepartment of Thoracic Surgery, San Raffaele Hospital, Via Olgettina, 60-20132 Milan, ItalyDepartment of Radiology, San Raffaele Hospital, Milan, Via Olgettina, 60-20132 Milan, ItalyDepartment of Radiology, San Raffaele Hospital, Milan, Via Olgettina, 60-20132 Milan, ItalyDepartment of Thoracic Surgery, San Raffaele Hospital, Via Olgettina, 60-20132 Milan, Italy<i>Background and objectives</i>: The histological classification and staging of thymic tumors remains a matter of debate. The correlation of computed tomography (CT) parameters with tumor histology and stage also still has to be completely assessed. The aim of this study was therefore to analyze the correlation of radiological parameters with histological and staging classifications of thymomas evaluating their prognostic role. <i>Materials and Methods</i>: Data of 50 patients with thymoma submitted to a complete surgical treatment between 2005 and 2015 were retrospectively analyzed. Tumors were classified according to the WHO and Suster and Moran (S&M) histological classifications and to the Masaoka–Koga and tumor, node and metastases (TNM) staging systems. The correlation of CT features with histology and stage and the prognostic role of histopathological and radiological features were assessed. <i>Results</i>: Five-year overall (OS) and disease-free survival (DFS) were 90.3% and 81.1%, respectively. A significant correlation of DFS with the Masaoka–Koga (<i>p</i> = 0.001) and TNM staging systems (<i>p</i> = 0.002) and with the S&M (<i>p</i> = 0.02) and WHO histological classifications (<i>p</i> = 0.04) was observed. CT scan features correlated with tumor stage, histology and prognosis. Moderately differentiated tumors (WHO B3) had a significantly higher incidence of irregular shape and contours (<i>p</i> = 0.002 and <i>p</i> = 0.001, respectively) and pericardial contact (<i>p</i> = 0.036). A larger tumor volume (<i>p</i> = 0.03) and a greater length of pleural contact (<i>p</i> = 0.04) adversely influenced DFS. The presence of pleural (<i>p</i> < 0.001) or lung invasion (<i>p</i> = 0.02) and of pleural effusion (<i>p</i> = 0.004) was associated with a significantly worse OS. <i>Conclusions</i>: Pre-operative CT scan parameters correlate with stage and histology, and have a prognostic role in surgically treated thymomas.https://www.mdpi.com/1648-9144/57/1/10thymomasurgeryhistologystagingCTprognosis |
| spellingShingle | Angelo Carretta Stefano Viscardi Piergiorgio Muriana Paola Ciriaco Alessandro Bandiera Roberto Varagona Michele Colombo Giampiero Negri Correlation of Computed Tomography Parameters with Histology, Stage and Prognosis in Surgically Treated Thymomas Medicina thymoma surgery histology staging CT prognosis |
| title | Correlation of Computed Tomography Parameters with Histology, Stage and Prognosis in Surgically Treated Thymomas |
| title_full | Correlation of Computed Tomography Parameters with Histology, Stage and Prognosis in Surgically Treated Thymomas |
| title_fullStr | Correlation of Computed Tomography Parameters with Histology, Stage and Prognosis in Surgically Treated Thymomas |
| title_full_unstemmed | Correlation of Computed Tomography Parameters with Histology, Stage and Prognosis in Surgically Treated Thymomas |
| title_short | Correlation of Computed Tomography Parameters with Histology, Stage and Prognosis in Surgically Treated Thymomas |
| title_sort | correlation of computed tomography parameters with histology stage and prognosis in surgically treated thymomas |
| topic | thymoma surgery histology staging CT prognosis |
| url | https://www.mdpi.com/1648-9144/57/1/10 |
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