Expression of suppressor of cytokine signaling 1 (SOCS1) impairs viral clearance and exacerbates lung injury during influenza infection.

Expression of suppressor of cytokine signaling 1 (SOCS1) impairs viral clearance and exacerbates lung injury during influenza infection.

Suppressor of cytokine signaling (SOCS) proteins are inducible feedback inhibitors of cytokine signaling. SOCS1-/- mice die within three weeks postnatally due to IFN-γ-induced hyperinflammation. Since it is well established that IFN-γ is dispensable for protection against influenza infection, we gen...

Full description

Bibliographic Details
Main Authors:	Keer Sun, Sharon Salmon, Vijaya Kumar Yajjala, Christopher Bauer, Dennis W Metzger
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2014-12-01
Series:	PLoS Pathogens
Online Access:	http://europepmc.org/articles/PMC4263766?pdf=render

Similar Items

Molecular characterization of two suppressor of cytokine signaling 1 genes (SOCS1a and SOCS1b) in chickens
by: Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG
Published: (2015-03-01)

Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling
by: Lukasz Kedzierski, et al.
Published: (2017-02-01)

Murine cytomegalovirus infection of mouse macrophages stimulates early expression of suppressor of cytokine signaling (SOCS)1 and SOCS3.
by: Christine I Alston, et al.
Published: (2017-01-01)

Nuclear localization of Suppressor of Cytokine Signaling (SOCS)-1 regulates local immunity in the lung
by: Jana Zimmer, et al.
Published: (2016-11-01)

Suppressor of cytokine signaling (SOCS) genes are downregulated in breast cancer
by: Soudeh Ghafouri-Fard, et al.
Published: (2018-11-01)

HTLV-1 evades Type 1 interferon antiviral signaling by inducing the suppressor of cytokine signaling 1 (SOCS1)
by: Hiscott John, et al.
Published: (2011-06-01)

Hedgehog/GLI signaling activates suppressor of cytokine signaling 1 (SOCS1) in epidermal and neural tumor cells.
by: Sandra Laner-Plamberger, et al.
Published: (2013-01-01)

HTLV-1 evades type I interferon antiviral signaling by inducing the suppressor of cytokine signaling 1 (SOCS1).
by: Stéphanie Olière, et al.
Published: (2010-11-01)

The Emerging Role of Suppressors of Cytokine Signaling (SOCS) in the Development and Progression of Leukemia
by: Esra’a Keewan, et al.
Published: (2021-08-01)

Suppressor of Cytokine Signaling 3 (SOCS3) Degrades p65 and Regulate HIV-1 Replication
by: Vikas Sood, et al.
Published: (2019-01-01)

Inflammatory Skin Diseases: Focus on the Role of Suppressors of Cytokine Signaling (SOCS) Proteins
by: Antonia Cianciulli, et al.
Published: (2024-03-01)

One gene to rule them all – clinical perspectives of a potent suppressor of cytokine signaling – SOCS1
by: Julia Körholz, et al.
Published: (2024-04-01)

Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1
by: Linossi, E, et al.
Published: (2013)

Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.
by: Edmond M Linossi, et al.
Published: (2013-01-01)

Molecular Cloning and Expression Analysis of Three Suppressors of Cytokine Signaling Genes (SOCS5, SOCS6, SOCS7) in the Mealworm Beetle Tenebrio molitor
by: Bharat Bhusan Patnaik, et al.
Published: (2019-03-01)

Role of Ubiquitylation in Controlling Suppressor of Cytokine Signalling 3 (SOCS3) Function and Expression
by: Jamie J. L. Williams, et al.
Published: (2014-05-01)

Regulation of insulin and leptin signaling by muscle suppressor of cytokine signaling 3 (SOCS3).
by: Zhenggang Yang, et al.
Published: (2012-01-01)

Suppressor of cytokine signaling 3 (SOCS3) is not an independent biomarker of colorectal adenoma risk
by: Sandler Robert S, et al.
Published: (2010-05-01)

Suppressor of cytokine signalling (SOCS) 1 and 3 enhance cell adhesion and inhibit migration towards the chemokine eotaxin/CCL11.
by: Stevenson, N, et al.
Published: (2010)

Expression of <it>M</it>. <it>tuberculosis</it>-induced suppressor of cytokine signaling (SOCS) 1, SOCS3, FoxP3 and secretion of IL-6 associates with differing clinical severity of tuberculosis
by: Masood Kiran I, et al.
Published: (2013-01-01)

Prognostic significance of SOCS1 and SOCS3 tumor suppressors and oncogenic signaling pathway genes in hepatocellular carcinoma
by: Md Gulam Musawwir Khan, et al.
Published: (2020-08-01)

Suppressor of cytokine signalling protein SOCS3 expression is increased at sites of acute and chronic inflammation.
by: White, G, et al.
Published: (2011)

Analysis of Suppressor of Cytokine Signaling 2 Gene (SOCS2) Polymorphism in Different Dog Breeds
by: Martina Miluchová, et al.
Published: (2023-11-01)

DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood
by: Prachand Issarapu, et al.
Published: (2023-08-01)

Suppressor of Cytokine Signalling 5 (SOCS5) Modulates Inflammatory Responses during Alphavirus Infection
by: Lukasz Kedzierski, et al.
Published: (2022-11-01)

Suppressor of cytokine signaling 1 (SOCS1) inhibits antiviral responses to facilitate Senecavirus A infection by regulating the NF-κB signaling pathway
by: Yongjie Chen, et al.
Published: (2022-05-01)

The Tumor Suppressor SOCS1 Diminishes Tolerance to Oxidative Stress in Hepatocellular Carcinoma
by: Akhil Shukla, et al.
Published: (2024-01-01)

Myeloid-derived suppressor cells in influenza virus-induced asthma exacerbation
by: Chiel van Geffen, et al.
Published: (2024-04-01)

Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase.
by: Zadjali, F, et al.
Published: (2011)

Zika Virus-Induction of the Suppressor of Cytokine Signaling 1/3 Contributes to the Modulation of Viral Replication
by: Rak-Kyun Seong, et al.
Published: (2020-02-01)

Influenza A (H1N1)pdm09 viral clearance kinetics in hospitalized children
by: Nazaret Sánchez, et al.
Published: (2021-10-01)

Human placental suppressors of cytokine signalling (SOCS) and inflammatory cytokines are dysregulated in assisted reproduction, advanced maternal age and pre-term birth
by: S. J. Knight, et al.
Published: (2020-04-01)

Inhibitory Mechanism of Signal Transduction through Chicken Leptin Receptor by Suppressor of Cytokine Signaling 3 (SOCS3)
by: Hiromi Adachi, et al.
Published: (2013-07-01)

Molecular Cloning and Gene Expression of Type I Suppressors of Cytokine Signaling 6 and 7 (SOCS6 and SOCS7) in Whiteleg Shrimp (<i>Litopenaeus vannamei</i>)
by: Gunasekara Chathura Wikumpriya, et al.
Published: (2023-08-01)

Ascorbate protects liver from metabolic disorder through inhibition of lipogenesis and suppressor of cytokine signaling 3 (SOCS3)
by: Yingying Xu, et al.
Published: (2020-03-01)

Interleukin-6 deficiency modulates testicular function by increasing the expression of suppressor of cytokine signaling 3 (SOCS3) in mice
by: Thaís Alves-Silva, et al.
Published: (2021-06-01)

Expression of suppressor of cytokine signaling 3 (SOCS3) and interleukin-6 (-174-G/C) polymorphism in atopic conditions.
by: Arooma Jannat, et al.
Published: (2019-01-01)

Role of suppressor of cytokine signaling-1 in murine atherosclerosis.
by: Christina Grothusen, et al.
Published: (2012-01-01)

Suppressor of Cytokine Signaling 3 in Macrophages Prevents Exacerbated Interleukin-6-Dependent Arginase-1 Activity and Early Permissiveness to Experimental Tuberculosis
by: Erik Schmok, et al.
Published: (2017-11-01)

Suppressor of cytokine signaling (SOCS) genes are silenced by DNA hypermethylation and histone deacetylation and regulate response to radiotherapy in cervical cancer cells.
by: Moon-Hong Kim, et al.
Published: (2015-01-01)