Shedding and extensive and prolonged environmental contamination of goat farms of Q fever patients by Coxiella burnetii
Abstract Background A majority (>70%) of Q fever patients in South Korea do not have a history of animal contact. Therefore, unconscious environmental exposure is suspected. The aim of this study was to investigate exposure of Q fever patients to environmental contamination and animal shedding. M...
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| Format: | Article |
| Language: | English |
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Wiley
2022-05-01
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| Series: | Veterinary Medicine and Science |
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| Online Access: | https://doi.org/10.1002/vms3.780 |
| _version_ | 1797683392075005952 |
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| author | Hyeon Seop Byeon Stalin Nattan Jun Hyoung Kim Seong Tae Han Mun Hui Chae Mi Na Han Byeongwoo Ahn Yong‐Dae Kim Hee‐Sung Kim Hye Won Jeong |
| author_facet | Hyeon Seop Byeon Stalin Nattan Jun Hyoung Kim Seong Tae Han Mun Hui Chae Mi Na Han Byeongwoo Ahn Yong‐Dae Kim Hee‐Sung Kim Hye Won Jeong |
| author_sort | Hyeon Seop Byeon |
| collection | DOAJ |
| description | Abstract Background A majority (>70%) of Q fever patients in South Korea do not have a history of animal contact. Therefore, unconscious environmental exposure is suspected. The aim of this study was to investigate exposure of Q fever patients to environmental contamination and animal shedding. Methods Two goat farmers were enrolled. One was diagnosed with Q fever 3 years ago (Farm 1). Among 20 goats on Farm 1, five were tested randomly and found to be Q fever PCR‐positive. Three of the five were Q fever ELISA‐positive. Two of five environmental samples taken in 2015 were PCR‐positive. In 2018, 17 of 18 environmental samples were PCR‐positive. On Farm 2, 54 of the 77 goats were PCR‐positive, and 63 were ELISA‐positive. Twelve of 14 environmental samples were PCR‐positive. Repeat administration of oxytetracycline to goats led to a gradual reduction in PCR‐positive tests over a 5‐month period. However, PCR‐positivity of the farm environment persisted for 5 months. Conclusion The environment on farms owned by Q fever patients was contaminated extensively and persistently, even after antibiotic treatment of goats and environmental decontamination. Undetected environmental contamination can be a major source of sporadic Q fever infection in South Korea. |
| first_indexed | 2024-03-12T00:14:42Z |
| format | Article |
| id | doaj.art-1c41951212ec4c0b8c2becc2ff42bdbf |
| institution | Directory Open Access Journal |
| issn | 2053-1095 |
| language | English |
| last_indexed | 2024-03-12T00:14:42Z |
| publishDate | 2022-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Medicine and Science |
| spelling | doaj.art-1c41951212ec4c0b8c2becc2ff42bdbf2023-09-15T15:20:44ZengWileyVeterinary Medicine and Science2053-10952022-05-01831264127010.1002/vms3.780Shedding and extensive and prolonged environmental contamination of goat farms of Q fever patients by Coxiella burnetiiHyeon Seop Byeon0Stalin Nattan1Jun Hyoung Kim2Seong Tae Han3Mun Hui Chae4Mi Na Han5Byeongwoo Ahn6Yong‐Dae Kim7Hee‐Sung Kim8Hye Won Jeong9Chungcheongbuk‐do Institute of Veterinary Service and Research Cheongju Republic of KoreaDepartment of Internal Medicine Chungbuk Natonal University College of Medicine Cheongju Republic of KoreaDepartment of Internal Medicine Chungbuk National University Hospital Cheongju Republic of KoreaChungcheongbuk‐do Institute of Veterinary Service and Research Cheongju Republic of KoreaChungcheongbuk‐do Institute of Veterinary Service and Research Cheongju Republic of KoreaChungcheongbuk‐do Institute of Veterinary Service and Research Cheongju Republic of KoreaCollege of Veterinary Medicine Chungbuk National University Cheongju Republic of KoreaDepartment of Preventive Medicine College of Medicine Chungbuk National University College of Medicine Cheongju Republic of KoreaDepartment of Internal Medicine Chungbuk Natonal University College of Medicine Cheongju Republic of KoreaDepartment of Internal Medicine Chungbuk Natonal University College of Medicine Cheongju Republic of KoreaAbstract Background A majority (>70%) of Q fever patients in South Korea do not have a history of animal contact. Therefore, unconscious environmental exposure is suspected. The aim of this study was to investigate exposure of Q fever patients to environmental contamination and animal shedding. Methods Two goat farmers were enrolled. One was diagnosed with Q fever 3 years ago (Farm 1). Among 20 goats on Farm 1, five were tested randomly and found to be Q fever PCR‐positive. Three of the five were Q fever ELISA‐positive. Two of five environmental samples taken in 2015 were PCR‐positive. In 2018, 17 of 18 environmental samples were PCR‐positive. On Farm 2, 54 of the 77 goats were PCR‐positive, and 63 were ELISA‐positive. Twelve of 14 environmental samples were PCR‐positive. Repeat administration of oxytetracycline to goats led to a gradual reduction in PCR‐positive tests over a 5‐month period. However, PCR‐positivity of the farm environment persisted for 5 months. Conclusion The environment on farms owned by Q fever patients was contaminated extensively and persistently, even after antibiotic treatment of goats and environmental decontamination. Undetected environmental contamination can be a major source of sporadic Q fever infection in South Korea.https://doi.org/10.1002/vms3.780Coxiella burnetiienvironmentgoat farmQ fevershedding |
| spellingShingle | Hyeon Seop Byeon Stalin Nattan Jun Hyoung Kim Seong Tae Han Mun Hui Chae Mi Na Han Byeongwoo Ahn Yong‐Dae Kim Hee‐Sung Kim Hye Won Jeong Shedding and extensive and prolonged environmental contamination of goat farms of Q fever patients by Coxiella burnetii Veterinary Medicine and Science Coxiella burnetii environment goat farm Q fever shedding |
| title | Shedding and extensive and prolonged environmental contamination of goat farms of Q fever patients by Coxiella burnetii |
| title_full | Shedding and extensive and prolonged environmental contamination of goat farms of Q fever patients by Coxiella burnetii |
| title_fullStr | Shedding and extensive and prolonged environmental contamination of goat farms of Q fever patients by Coxiella burnetii |
| title_full_unstemmed | Shedding and extensive and prolonged environmental contamination of goat farms of Q fever patients by Coxiella burnetii |
| title_short | Shedding and extensive and prolonged environmental contamination of goat farms of Q fever patients by Coxiella burnetii |
| title_sort | shedding and extensive and prolonged environmental contamination of goat farms of q fever patients by coxiella burnetii |
| topic | Coxiella burnetii environment goat farm Q fever shedding |
| url | https://doi.org/10.1002/vms3.780 |
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