The Role of Extracellular Vesicles in the Pathogenesis, Diagnosis, and Treatment of Osteoarthritis
Osteoarthritis (OA) is a degenerative joint disease that affects the entire joint and has been a tremendous burden on the health care system worldwide. Although cell therapy has made significant progress in the treatment of OA and cartilage regeneration, there are still a series of problems. Recentl...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/16/4987 |
| _version_ | 1797522681243893760 |
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| author | Jianjing Lin Li Wang Jianhao Lin Qiang Liu |
| author_facet | Jianjing Lin Li Wang Jianhao Lin Qiang Liu |
| author_sort | Jianjing Lin |
| collection | DOAJ |
| description | Osteoarthritis (OA) is a degenerative joint disease that affects the entire joint and has been a tremendous burden on the health care system worldwide. Although cell therapy has made significant progress in the treatment of OA and cartilage regeneration, there are still a series of problems. Recently, more and more evidence shows that extracellular vesicles (EVs) play an important role in the progression and treatment of OA. Here, we discuss that EVs from different cell sources not only participate in OA progression, but can also be used as effective tools for the diagnosis and treatment of OA. In addition, cell pretreatment strategies and EV tissue engineering play an increasingly prominent role in the field of OA treatment. This article will systematically review the latest developments in these areas. As stated above, it may provide new insights for improving OA and cartilage regeneration. |
| first_indexed | 2024-03-10T08:32:54Z |
| format | Article |
| id | doaj.art-1c420afe46c040a095d17b680636d0ae |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T08:32:54Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-1c420afe46c040a095d17b680636d0ae2023-11-22T08:54:54ZengMDPI AGMolecules1420-30492021-08-012616498710.3390/molecules26164987The Role of Extracellular Vesicles in the Pathogenesis, Diagnosis, and Treatment of OsteoarthritisJianjing Lin0Li Wang1Jianhao Lin2Qiang Liu3Arthritis Clinical and Research Center, Peking University People’s Hospital, No. 11 Xizhimen South Street, Beijing 100044, ChinaDepartment of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, ChinaArthritis Clinical and Research Center, Peking University People’s Hospital, No. 11 Xizhimen South Street, Beijing 100044, ChinaArthritis Clinical and Research Center, Peking University People’s Hospital, No. 11 Xizhimen South Street, Beijing 100044, ChinaOsteoarthritis (OA) is a degenerative joint disease that affects the entire joint and has been a tremendous burden on the health care system worldwide. Although cell therapy has made significant progress in the treatment of OA and cartilage regeneration, there are still a series of problems. Recently, more and more evidence shows that extracellular vesicles (EVs) play an important role in the progression and treatment of OA. Here, we discuss that EVs from different cell sources not only participate in OA progression, but can also be used as effective tools for the diagnosis and treatment of OA. In addition, cell pretreatment strategies and EV tissue engineering play an increasingly prominent role in the field of OA treatment. This article will systematically review the latest developments in these areas. As stated above, it may provide new insights for improving OA and cartilage regeneration.https://www.mdpi.com/1420-3049/26/16/4987extracellular vesiclesosteoarthritis |
| spellingShingle | Jianjing Lin Li Wang Jianhao Lin Qiang Liu The Role of Extracellular Vesicles in the Pathogenesis, Diagnosis, and Treatment of Osteoarthritis Molecules extracellular vesicles osteoarthritis |
| title | The Role of Extracellular Vesicles in the Pathogenesis, Diagnosis, and Treatment of Osteoarthritis |
| title_full | The Role of Extracellular Vesicles in the Pathogenesis, Diagnosis, and Treatment of Osteoarthritis |
| title_fullStr | The Role of Extracellular Vesicles in the Pathogenesis, Diagnosis, and Treatment of Osteoarthritis |
| title_full_unstemmed | The Role of Extracellular Vesicles in the Pathogenesis, Diagnosis, and Treatment of Osteoarthritis |
| title_short | The Role of Extracellular Vesicles in the Pathogenesis, Diagnosis, and Treatment of Osteoarthritis |
| title_sort | role of extracellular vesicles in the pathogenesis diagnosis and treatment of osteoarthritis |
| topic | extracellular vesicles osteoarthritis |
| url | https://www.mdpi.com/1420-3049/26/16/4987 |
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