Nanoparticle-Encapsulated Curcumin Inhibits Diabetic Neuropathic Pain Involving the P2Y12 Receptor in the Dorsal Root Ganglia

Nanoparticle-Encapsulated Curcumin Inhibits Diabetic Neuropathic Pain Involving the P2Y12 Receptor in the Dorsal Root Ganglia

Diabetic peripheral neuropathy results in diabetic neuropathic pain (DNP). Satellite glial cells (SGCs) enwrap the neuronal soma in the dorsal root ganglia (DRG). The purinergic 2 (P2) Y12 receptor is expressed on SGCs in the DRG. SGC activation plays an important role in the pathogenesis of DNP. Cu...

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Bibliographic Details
Main Authors: Tianyu Jia, Jingan Rao, Lifang Zou, Shanhong Zhao, Zhihua Yi, Bing Wu, Lin Li, Huilong Yuan, Liran Shi, Chunping Zhang, Yun Gao, Shuangmei Liu, Hong Xu, Hui Liu, Shangdong Liang, Guilin Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Neuroscience
Subjects:
nanoparticle-encapsulated curcumin
P2Y12 receptor
diabetic neuropathic pain
dorsal root ganglia
satellite glial cells
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2017.00755/full

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