Analysis of the MTHFR C677T variant with migraine phenotypes
<p>Abstract</p> <p>Background</p> <p>The methylenetetrahydrofolate reductase (MTHFR) gene variant C677T has been implicated as a genetic risk factor in migraine susceptibility, particularly in Migraine with Aura. Migraine, with and without aura (MA and MO) have many dia...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-07-01
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| Series: | BMC Research Notes |
| Online Access: | http://www.biomedcentral.com/1756-0500/3/213 |
| _version_ | 1811284466272829440 |
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| author | Haupt Larisa M Tiang Thomas Peterson Madelyn Cox Hannah Quinlan Sharon Colson Natalie J Menon Saraswathy Liu Annie Lea Rod A Griffiths Lyn R |
| author_facet | Haupt Larisa M Tiang Thomas Peterson Madelyn Cox Hannah Quinlan Sharon Colson Natalie J Menon Saraswathy Liu Annie Lea Rod A Griffiths Lyn R |
| author_sort | Haupt Larisa M |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The methylenetetrahydrofolate reductase (MTHFR) gene variant C677T has been implicated as a genetic risk factor in migraine susceptibility, particularly in Migraine with Aura. Migraine, with and without aura (MA and MO) have many diagnostic characteristics in common. It is postulated that migraine symptomatic characteristics might themselves be influenced by MTHFR. Here we analysed the clinical profile, migraine symptoms, triggers and treatments of 267 migraineurs previously genotyped for the MTHFR C677T variant. The chi-square test was used to analyse all potential relationships between genotype and migraine clinical variables. Regression analyses were performed to assess the association of C677T with all migraine clinical variables after adjusting for gender.</p> <p>Findings</p> <p>The homozygous TT genotype was significantly associated with MA (<it>P </it>< 0.0001) and unilateral head pain (<it>P </it>= 0.002). While the CT genotype was significantly associated with physical activity discomfort (<it>P </it>< 0.001) and stress as a migraine trigger (<it>P </it>= 0.002). Females with the TT genotype were significantly associated with unilateral head pain (<it>P </it>< 0.001) and females with the CT genotype were significantly associated with nausea (<it>P </it>< 0.001), osmophobia (<it>P </it>= 0.002), and the use of natural remedy for migraine treatment (<it>P </it>= 0.003). Conversely, male migraineurs with the TT genotype experienced higher incidences of bilateral head pain (63% vs 34%) and were less likely to use a natural remedy as a migraine treatment compared to female migraineurs (5% vs 20%).</p> <p>Conclusions</p> <p>MTHFR genotype is associated with specific clinical variables of migraine including unilateral head pain, physical activity discomfort and stress.</p> |
| first_indexed | 2024-04-13T02:29:06Z |
| format | Article |
| id | doaj.art-1c44485caf3546488203fdd2ed0d24b8 |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-04-13T02:29:06Z |
| publishDate | 2010-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-1c44485caf3546488203fdd2ed0d24b82022-12-22T03:06:39ZengBMCBMC Research Notes1756-05002010-07-013121310.1186/1756-0500-3-213Analysis of the MTHFR C677T variant with migraine phenotypesHaupt Larisa MTiang ThomasPeterson MadelynCox HannahQuinlan SharonColson Natalie JMenon SaraswathyLiu AnnieLea Rod AGriffiths Lyn R<p>Abstract</p> <p>Background</p> <p>The methylenetetrahydrofolate reductase (MTHFR) gene variant C677T has been implicated as a genetic risk factor in migraine susceptibility, particularly in Migraine with Aura. Migraine, with and without aura (MA and MO) have many diagnostic characteristics in common. It is postulated that migraine symptomatic characteristics might themselves be influenced by MTHFR. Here we analysed the clinical profile, migraine symptoms, triggers and treatments of 267 migraineurs previously genotyped for the MTHFR C677T variant. The chi-square test was used to analyse all potential relationships between genotype and migraine clinical variables. Regression analyses were performed to assess the association of C677T with all migraine clinical variables after adjusting for gender.</p> <p>Findings</p> <p>The homozygous TT genotype was significantly associated with MA (<it>P </it>< 0.0001) and unilateral head pain (<it>P </it>= 0.002). While the CT genotype was significantly associated with physical activity discomfort (<it>P </it>< 0.001) and stress as a migraine trigger (<it>P </it>= 0.002). Females with the TT genotype were significantly associated with unilateral head pain (<it>P </it>< 0.001) and females with the CT genotype were significantly associated with nausea (<it>P </it>< 0.001), osmophobia (<it>P </it>= 0.002), and the use of natural remedy for migraine treatment (<it>P </it>= 0.003). Conversely, male migraineurs with the TT genotype experienced higher incidences of bilateral head pain (63% vs 34%) and were less likely to use a natural remedy as a migraine treatment compared to female migraineurs (5% vs 20%).</p> <p>Conclusions</p> <p>MTHFR genotype is associated with specific clinical variables of migraine including unilateral head pain, physical activity discomfort and stress.</p>http://www.biomedcentral.com/1756-0500/3/213 |
| spellingShingle | Haupt Larisa M Tiang Thomas Peterson Madelyn Cox Hannah Quinlan Sharon Colson Natalie J Menon Saraswathy Liu Annie Lea Rod A Griffiths Lyn R Analysis of the MTHFR C677T variant with migraine phenotypes BMC Research Notes |
| title | Analysis of the MTHFR C677T variant with migraine phenotypes |
| title_full | Analysis of the MTHFR C677T variant with migraine phenotypes |
| title_fullStr | Analysis of the MTHFR C677T variant with migraine phenotypes |
| title_full_unstemmed | Analysis of the MTHFR C677T variant with migraine phenotypes |
| title_short | Analysis of the MTHFR C677T variant with migraine phenotypes |
| title_sort | analysis of the mthfr c677t variant with migraine phenotypes |
| url | http://www.biomedcentral.com/1756-0500/3/213 |
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