<i>Plasmodium falciparum</i> S-Adenosylmethionine Synthetase Is Essential for Parasite Survival through a Complex Interaction Network with Cytoplasmic and Nuclear Proteins

<i>Plasmodium falciparum</i> S-Adenosylmethionine Synthetase Is Essential for Parasite Survival through a Complex Interaction Network with Cytoplasmic and Nuclear Proteins

S-adenosylmethionine synthetase (SAMS) is a key enzyme for the synthesis of the lone methyl donor S-adenosyl methionine (SAM), which is involved in transmethylation reactions and hence required for cellular processes such as DNA, RNA, and histone methylation, but also polyamine biosynthesis and prot...

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Bibliographic Details
Main Authors: Jean Pierre Musabyimana, Ute Distler, Juliane Sassmannshausen, Christina Berks, Janice Manti, Sandra Bennink, Lea Blaschke, Paul-Christian Burda, Ansgar Flammersfeld, Stefan Tenzer, Che Julius Ngwa, Gabriele Pradel
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Microorganisms
Subjects:
<i>Plasmodium falciparum</i>
malaria
histone methylation
polyamine biosynthesis
SAMS
SAM
Online Access:https://www.mdpi.com/2076-2607/10/7/1419

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