Cardiometabolic Profile, Physical Activity, and Quality of Life in Breast Cancer Survivors after Different Physical Exercise Protocols: A 34-Month Follow-Up Study
Background: Breast cancer (BC) and cardiovascular (CV) disease share many risk factors associated with worse outcomes, in terms of cancer relapse, CV events, and quality of life (QoL), that could be counteracted by physical exercise (PE). We aimed to assess the impact of a 12-week differential PE pr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/14/4795 |
| _version_ | 1797588813367738368 |
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| author | Valentina Bucciarelli Francesco Bianco Andrea Di Blasio Teresa Morano Desiree Tuosto Francesco Mucedola Serena Di Santo Alessandra Cimini Giorgio Napolitano Ines Bucci Angela Di Baldassarre Ettore Cianchetti Sabina Gallina |
| author_facet | Valentina Bucciarelli Francesco Bianco Andrea Di Blasio Teresa Morano Desiree Tuosto Francesco Mucedola Serena Di Santo Alessandra Cimini Giorgio Napolitano Ines Bucci Angela Di Baldassarre Ettore Cianchetti Sabina Gallina |
| author_sort | Valentina Bucciarelli |
| collection | DOAJ |
| description | Background: Breast cancer (BC) and cardiovascular (CV) disease share many risk factors associated with worse outcomes, in terms of cancer relapse, CV events, and quality of life (QoL), that could be counteracted by physical exercise (PE). We aimed to assess the impact of a 12-week differential PE protocol on cardiometabolic profile, QoL, CV- and BC-related long-term outcomes, and physical activity (PA) in a cohort of BC survivors (BCS) not treated with chemotherapy. Methods: 57 BCS participated in a 12-week PE protocol [aerobic exercise training (AET) or resistance exercise training (RET)]. Anthropometric and CV evaluation, health-related (HR)-QoL, daily PA, cortisol, and dehydroepiandrosterone sulfate (DHEA-S) levels were assessed before (T0) and after (T1) PE. We assessed BC and CV outcomes, HR-QoL, CV-QoL, and PA at the follow-up. Results: RET improved waist circumference, DHEA-S, cortisol/DHEA-S, systolic and mean blood pressure, and ventricular/arterial coupling; AET ameliorated sagittal abdomen diameter and pulse wave velocity. Regarding HR-QoL, physical function improved only in AET group. At a mean 34 ± 3.6-month follow-up, we documented no significant differences in CV-QoL, HR-QoL, and PA or CV and BC outcomes. Conclusions: AET and RET determine specific, positive adaptations on many parameters strongly related to CV risk, CV and BC outcomes, and QoL, and should be included in any cardio-oncology rehabilitation program. |
| first_indexed | 2024-03-11T00:57:26Z |
| format | Article |
| id | doaj.art-1c46c33aa4dd4af9aaa661deff85fed6 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T00:57:26Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-1c46c33aa4dd4af9aaa661deff85fed62023-11-18T19:54:05ZengMDPI AGJournal of Clinical Medicine2077-03832023-07-011214479510.3390/jcm12144795Cardiometabolic Profile, Physical Activity, and Quality of Life in Breast Cancer Survivors after Different Physical Exercise Protocols: A 34-Month Follow-Up StudyValentina Bucciarelli0Francesco Bianco1Andrea Di Blasio2Teresa Morano3Desiree Tuosto4Francesco Mucedola5Serena Di Santo6Alessandra Cimini7Giorgio Napolitano8Ines Bucci9Angela Di Baldassarre10Ettore Cianchetti11Sabina Gallina12Cardiovascular Sciences Department—Azienda Ospedaliero-Universitaria delle Marche, 60126 Ancona, ItalyCardiovascular Sciences Department—Azienda Ospedaliero-Universitaria delle Marche, 60126 Ancona, ItalyDepartment of Medicine and Aging Sciences, “G. d’Annunzio” University, 66100 Chieti, ItalyDepartment of Medicine and Aging Sciences, “G. d’Annunzio” University, 66100 Chieti, ItalyDepartment of Neurosciences, Imaging and Clinical Sciences, “G. d’Annunzio” University, 66100 Chieti, ItalyDepartment of Neurosciences, Imaging and Clinical Sciences, “G. d’Annunzio” University, 66100 Chieti, ItalyDepartment of Medicine and Aging Sciences, “G. d’Annunzio” University, 66100 Chieti, ItalyEusoma Breast Centre, “G. Bernabeo” Hospital, ASL02 Lanciano-Vasto-Chieti, 66026 Ortona, ItalyDepartment of Medicine and Aging Sciences, “G. d’Annunzio” University, 66100 Chieti, ItalyCenter for Advanced Studies and Technology (CAST), “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, ItalyDepartment of Medicine and Aging Sciences, “G. d’Annunzio” University, 66100 Chieti, ItalyEusoma Breast Centre, “G. Bernabeo” Hospital, ASL02 Lanciano-Vasto-Chieti, 66026 Ortona, ItalyDepartment of Neurosciences, Imaging and Clinical Sciences, “G. d’Annunzio” University, 66100 Chieti, ItalyBackground: Breast cancer (BC) and cardiovascular (CV) disease share many risk factors associated with worse outcomes, in terms of cancer relapse, CV events, and quality of life (QoL), that could be counteracted by physical exercise (PE). We aimed to assess the impact of a 12-week differential PE protocol on cardiometabolic profile, QoL, CV- and BC-related long-term outcomes, and physical activity (PA) in a cohort of BC survivors (BCS) not treated with chemotherapy. Methods: 57 BCS participated in a 12-week PE protocol [aerobic exercise training (AET) or resistance exercise training (RET)]. Anthropometric and CV evaluation, health-related (HR)-QoL, daily PA, cortisol, and dehydroepiandrosterone sulfate (DHEA-S) levels were assessed before (T0) and after (T1) PE. We assessed BC and CV outcomes, HR-QoL, CV-QoL, and PA at the follow-up. Results: RET improved waist circumference, DHEA-S, cortisol/DHEA-S, systolic and mean blood pressure, and ventricular/arterial coupling; AET ameliorated sagittal abdomen diameter and pulse wave velocity. Regarding HR-QoL, physical function improved only in AET group. At a mean 34 ± 3.6-month follow-up, we documented no significant differences in CV-QoL, HR-QoL, and PA or CV and BC outcomes. Conclusions: AET and RET determine specific, positive adaptations on many parameters strongly related to CV risk, CV and BC outcomes, and QoL, and should be included in any cardio-oncology rehabilitation program.https://www.mdpi.com/2077-0383/12/14/4795breast cancerbreast cancer survivorscancer therapy-related cardiovascular toxicityhormone therapyphysical exerciseaerobic exercise training |
| spellingShingle | Valentina Bucciarelli Francesco Bianco Andrea Di Blasio Teresa Morano Desiree Tuosto Francesco Mucedola Serena Di Santo Alessandra Cimini Giorgio Napolitano Ines Bucci Angela Di Baldassarre Ettore Cianchetti Sabina Gallina Cardiometabolic Profile, Physical Activity, and Quality of Life in Breast Cancer Survivors after Different Physical Exercise Protocols: A 34-Month Follow-Up Study Journal of Clinical Medicine breast cancer breast cancer survivors cancer therapy-related cardiovascular toxicity hormone therapy physical exercise aerobic exercise training |
| title | Cardiometabolic Profile, Physical Activity, and Quality of Life in Breast Cancer Survivors after Different Physical Exercise Protocols: A 34-Month Follow-Up Study |
| title_full | Cardiometabolic Profile, Physical Activity, and Quality of Life in Breast Cancer Survivors after Different Physical Exercise Protocols: A 34-Month Follow-Up Study |
| title_fullStr | Cardiometabolic Profile, Physical Activity, and Quality of Life in Breast Cancer Survivors after Different Physical Exercise Protocols: A 34-Month Follow-Up Study |
| title_full_unstemmed | Cardiometabolic Profile, Physical Activity, and Quality of Life in Breast Cancer Survivors after Different Physical Exercise Protocols: A 34-Month Follow-Up Study |
| title_short | Cardiometabolic Profile, Physical Activity, and Quality of Life in Breast Cancer Survivors after Different Physical Exercise Protocols: A 34-Month Follow-Up Study |
| title_sort | cardiometabolic profile physical activity and quality of life in breast cancer survivors after different physical exercise protocols a 34 month follow up study |
| topic | breast cancer breast cancer survivors cancer therapy-related cardiovascular toxicity hormone therapy physical exercise aerobic exercise training |
| url | https://www.mdpi.com/2077-0383/12/14/4795 |
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