Trends in Application of SERS Substrates beyond Ag and Au, and Their Role in Bioanalysis
This article compares the applications of traditional gold and silver-based SERS substrates and less conventional (Pd/Pt, Cu, Al, Si-based) SERS substrates, focusing on sensing, biosensing, and clinical analysis. In recent decades plethora of new biosensing and clinical SERS applications have fueled...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/12/11/967 |
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| author | Alisher Sultangaziyev Aisha Ilyas Aigerim Dyussupova Rostislav Bukasov |
| author_facet | Alisher Sultangaziyev Aisha Ilyas Aigerim Dyussupova Rostislav Bukasov |
| author_sort | Alisher Sultangaziyev |
| collection | DOAJ |
| description | This article compares the applications of traditional gold and silver-based SERS substrates and less conventional (Pd/Pt, Cu, Al, Si-based) SERS substrates, focusing on sensing, biosensing, and clinical analysis. In recent decades plethora of new biosensing and clinical SERS applications have fueled the search for more cost-effective, scalable, and stable substrates since traditional gold and silver-based substrates are quite expensive, prone to corrosion, contamination and non-specific binding, particularly by S-containing compounds. Following that, we briefly described our experimental experience with Si and Al-based SERS substrates and systematically analyzed the literature on SERS on substrate materials such as Pd/Pt, Cu, Al, and Si. We tabulated and discussed figures of merit such as enhancement factor (EF) and limit of detection (LOD) from analytical applications of these substrates. The results of the comparison showed that Pd/Pt substrates are not practical due to their high cost; Cu-based substrates are less stable and produce lower signal enhancement. Si and Al-based substrates showed promising results, particularly in combination with gold and silver nanostructures since they could produce comparable EFs and LODs as conventional substrates. In addition, their stability and relatively low cost make them viable alternatives for gold and silver-based substrates. Finally, this review highlighted and compared the clinical performance of non-traditional SERS substrates and traditional gold and silver SERS substrates. We discovered that if we take the average sensitivity, specificity, and accuracy of clinical SERS assays reported in the literature, those parameters, particularly accuracy (93–94%), are similar for SERS bioassays on AgNP@Al, Si-based, Au-based, and Ag-based substrates. We hope that this review will encourage research into SERS biosensing on aluminum, silicon, and some other substrates. These Al and Si based substrates may respond efficiently to the major challenges to the SERS practical application. For instance, they may be not only less expensive, e.g., Al foil, but also in some cases more selective and sometimes more reproducible, when compared to gold-only or silver-only based SERS substrates. Overall, it may result in a greater diversity of applicable SERS substrates, allowing for better optimization and selection of the SERS substrate for a specific sensing/biosensing or clinical application. |
| first_indexed | 2024-03-09T19:13:54Z |
| format | Article |
| id | doaj.art-1c4734b867104ab7a134c4c2ae3db33b |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-09T19:13:54Z |
| publishDate | 2022-11-01 |
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| series | Biosensors |
| spelling | doaj.art-1c4734b867104ab7a134c4c2ae3db33b2023-11-24T03:55:09ZengMDPI AGBiosensors2079-63742022-11-01121196710.3390/bios12110967Trends in Application of SERS Substrates beyond Ag and Au, and Their Role in BioanalysisAlisher Sultangaziyev0Aisha Ilyas1Aigerim Dyussupova2Rostislav Bukasov3Department of Chemistry, School of Sciences and Humanities (SSH) Nazarbayev University, Kabanbay Batyr av. 53, Astana 010000, KazakhstanDepartment of Chemistry, School of Sciences and Humanities (SSH) Nazarbayev University, Kabanbay Batyr av. 53, Astana 010000, KazakhstanDepartment of Chemistry, School of Sciences and Humanities (SSH) Nazarbayev University, Kabanbay Batyr av. 53, Astana 010000, KazakhstanDepartment of Chemistry, School of Sciences and Humanities (SSH) Nazarbayev University, Kabanbay Batyr av. 53, Astana 010000, KazakhstanThis article compares the applications of traditional gold and silver-based SERS substrates and less conventional (Pd/Pt, Cu, Al, Si-based) SERS substrates, focusing on sensing, biosensing, and clinical analysis. In recent decades plethora of new biosensing and clinical SERS applications have fueled the search for more cost-effective, scalable, and stable substrates since traditional gold and silver-based substrates are quite expensive, prone to corrosion, contamination and non-specific binding, particularly by S-containing compounds. Following that, we briefly described our experimental experience with Si and Al-based SERS substrates and systematically analyzed the literature on SERS on substrate materials such as Pd/Pt, Cu, Al, and Si. We tabulated and discussed figures of merit such as enhancement factor (EF) and limit of detection (LOD) from analytical applications of these substrates. The results of the comparison showed that Pd/Pt substrates are not practical due to their high cost; Cu-based substrates are less stable and produce lower signal enhancement. Si and Al-based substrates showed promising results, particularly in combination with gold and silver nanostructures since they could produce comparable EFs and LODs as conventional substrates. In addition, their stability and relatively low cost make them viable alternatives for gold and silver-based substrates. Finally, this review highlighted and compared the clinical performance of non-traditional SERS substrates and traditional gold and silver SERS substrates. We discovered that if we take the average sensitivity, specificity, and accuracy of clinical SERS assays reported in the literature, those parameters, particularly accuracy (93–94%), are similar for SERS bioassays on AgNP@Al, Si-based, Au-based, and Ag-based substrates. We hope that this review will encourage research into SERS biosensing on aluminum, silicon, and some other substrates. These Al and Si based substrates may respond efficiently to the major challenges to the SERS practical application. For instance, they may be not only less expensive, e.g., Al foil, but also in some cases more selective and sometimes more reproducible, when compared to gold-only or silver-only based SERS substrates. Overall, it may result in a greater diversity of applicable SERS substrates, allowing for better optimization and selection of the SERS substrate for a specific sensing/biosensing or clinical application.https://www.mdpi.com/2079-6374/12/11/967SERSclinical applicationsLODclinical sensitivitydetection of biomarkersimmunoassays |
| spellingShingle | Alisher Sultangaziyev Aisha Ilyas Aigerim Dyussupova Rostislav Bukasov Trends in Application of SERS Substrates beyond Ag and Au, and Their Role in Bioanalysis Biosensors SERS clinical applications LOD clinical sensitivity detection of biomarkers immunoassays |
| title | Trends in Application of SERS Substrates beyond Ag and Au, and Their Role in Bioanalysis |
| title_full | Trends in Application of SERS Substrates beyond Ag and Au, and Their Role in Bioanalysis |
| title_fullStr | Trends in Application of SERS Substrates beyond Ag and Au, and Their Role in Bioanalysis |
| title_full_unstemmed | Trends in Application of SERS Substrates beyond Ag and Au, and Their Role in Bioanalysis |
| title_short | Trends in Application of SERS Substrates beyond Ag and Au, and Their Role in Bioanalysis |
| title_sort | trends in application of sers substrates beyond ag and au and their role in bioanalysis |
| topic | SERS clinical applications LOD clinical sensitivity detection of biomarkers immunoassays |
| url | https://www.mdpi.com/2079-6374/12/11/967 |
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