Transverse myelitis following COVID-19 infection. What is the mechanism? A case report and literature review
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak became one of the most global health challenges in the recent century. Transverse myelitis is a rare medical condition reported in few case reports following COVID-19 infection. We present a 63 years old female with post-COVID...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2021-06-01
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| Series: | Romanian Journal of Neurology |
| Subjects: | |
| Online Access: | https://rjn.com.ro/articles/2021.2/RJN_2021_2_Art-22.pdf |
| _version_ | 1827312155976794112 |
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| author | Babak Alijani Alia Saberi Parham Niyasti Mohammad Haghani Dogahe |
| author_facet | Babak Alijani Alia Saberi Parham Niyasti Mohammad Haghani Dogahe |
| author_sort | Babak Alijani |
| collection | DOAJ |
| description | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak became one of the most global health challenges in the recent century. Transverse myelitis is a rare medical condition reported in few case reports following COVID-19 infection. We present a 63 years old female with post-COVID-19 transverse myelitis. The patient had paraplegia combined with autonomic symptoms and T4 sensory level. Initial treatment started with methylprednisolone. Since the patient did not respond to the prednisolone, plasmapheresis was considered for the patient. Unfortunately, the patient could not tolerate the plasmapheresis. We considered rituximab for the next plan, but unfortunately, the patient died due to respiratory failure. To date, there is no published study to evaluate different mechanisms of post/para COVID-19 transverse myelitis. However, the post/para COVID-19 transverse myelitis mechanism seems to be heterogeneous; the activation of a silent autoimmune disease can probably justify some unusual clinical presentations of a viral illness. Further studies are needed to categorize the underlying mechanisms of post/para COVID-19 transverse myelitis and effective treatments regarding the primary pathology. |
| first_indexed | 2024-04-24T21:38:01Z |
| format | Article |
| id | doaj.art-1c4923dd6144479e9d13ca33d68d5f81 |
| institution | Directory Open Access Journal |
| issn | 1843-8148 2069-6094 |
| language | English |
| last_indexed | 2024-04-24T21:38:01Z |
| publishDate | 2021-06-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Neurology |
| spelling | doaj.art-1c4923dd6144479e9d13ca33d68d5f812024-03-21T14:38:16ZengAmaltea Medical Publishing HouseRomanian Journal of Neurology1843-81482069-60942021-06-0120225526310.37897/RJN.2021.2.22Transverse myelitis following COVID-19 infection. What is the mechanism? A case report and literature reviewBabak Alijani0Alia Saberi1Parham Niyasti2Mohammad Haghani Dogahe3Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, IranNeuroscience Research Center, Department of Neurology, Poursina Hospital, Guilan University of Medical Sciences, Rasht, IranDepartment of Neurology, Guilan University of Medical Science, Rasht, IranResearch Committee, School of Medicine, Guilan University of Medical Science, Rasht, IranThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak became one of the most global health challenges in the recent century. Transverse myelitis is a rare medical condition reported in few case reports following COVID-19 infection. We present a 63 years old female with post-COVID-19 transverse myelitis. The patient had paraplegia combined with autonomic symptoms and T4 sensory level. Initial treatment started with methylprednisolone. Since the patient did not respond to the prednisolone, plasmapheresis was considered for the patient. Unfortunately, the patient could not tolerate the plasmapheresis. We considered rituximab for the next plan, but unfortunately, the patient died due to respiratory failure. To date, there is no published study to evaluate different mechanisms of post/para COVID-19 transverse myelitis. However, the post/para COVID-19 transverse myelitis mechanism seems to be heterogeneous; the activation of a silent autoimmune disease can probably justify some unusual clinical presentations of a viral illness. Further studies are needed to categorize the underlying mechanisms of post/para COVID-19 transverse myelitis and effective treatments regarding the primary pathology.https://rjn.com.ro/articles/2021.2/RJN_2021_2_Art-22.pdftransverse myelitissars-cov-2post/para covid-19autoimmune mechanism |
| spellingShingle | Babak Alijani Alia Saberi Parham Niyasti Mohammad Haghani Dogahe Transverse myelitis following COVID-19 infection. What is the mechanism? A case report and literature review Romanian Journal of Neurology transverse myelitis sars-cov-2 post/para covid-19 autoimmune mechanism |
| title | Transverse myelitis following COVID-19 infection. What is the mechanism? A case report and literature review |
| title_full | Transverse myelitis following COVID-19 infection. What is the mechanism? A case report and literature review |
| title_fullStr | Transverse myelitis following COVID-19 infection. What is the mechanism? A case report and literature review |
| title_full_unstemmed | Transverse myelitis following COVID-19 infection. What is the mechanism? A case report and literature review |
| title_short | Transverse myelitis following COVID-19 infection. What is the mechanism? A case report and literature review |
| title_sort | transverse myelitis following covid 19 infection what is the mechanism a case report and literature review |
| topic | transverse myelitis sars-cov-2 post/para covid-19 autoimmune mechanism |
| url | https://rjn.com.ro/articles/2021.2/RJN_2021_2_Art-22.pdf |
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