Correlation of MRI-Lesion Targeted Biopsy vs. Systematic Biopsy Gleason Score with Final Pathological Gleason Score after Radical Prostatectomy
Background: The impact of MRI-lesion targeted (TB) and systematic biopsy (SB) Gleason score (GS) as a predictor for final pathological GS still remains unclear. Methods: All patients with TB + SB, and subsequent radical prostatectomy (RP) between 01/2014-12/2020 were analyzed. Rank correlation coeff...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-05-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/11/5/882 |
| _version_ | 1827692410223722496 |
|---|---|
| author | Mike Wenzel Felix Preisser Clarissa Wittler Benedikt Hoeh Peter J. Wild Alexandra Tschäbunin Boris Bodelle Christoph Würnschimmel Derya Tilki Markus Graefen Andreas Becker Pierre I Karakiewicz Felix K. H. Chun Luis A Kluth Jens Köllermann Philipp Mandel |
| author_facet | Mike Wenzel Felix Preisser Clarissa Wittler Benedikt Hoeh Peter J. Wild Alexandra Tschäbunin Boris Bodelle Christoph Würnschimmel Derya Tilki Markus Graefen Andreas Becker Pierre I Karakiewicz Felix K. H. Chun Luis A Kluth Jens Köllermann Philipp Mandel |
| author_sort | Mike Wenzel |
| collection | DOAJ |
| description | Background: The impact of MRI-lesion targeted (TB) and systematic biopsy (SB) Gleason score (GS) as a predictor for final pathological GS still remains unclear. Methods: All patients with TB + SB, and subsequent radical prostatectomy (RP) between 01/2014-12/2020 were analyzed. Rank correlation coefficient predicted concordance with pathological GS for patients’ TB and SB GS, as well as for the combined effect of SB + TB. Results: Of 159 eligible patients, 77% were biopsy naïve. For SB taken in addition to TB, a Spearman’s correlation of +0.33 was observed regarding final GS. Rates of concordance, upgrading, and downgrading were 37.1, 37.1 and 25.8%, respectively. For TB, a +0.52 correlation was computed regarding final GS. Rates of concordance, upgrading and downgrading for TB biopsy GS were 45.9, 33.3, and 20.8%, respectively. For the combination of SB + TB, a correlation of +0.59 was observed. Rates of concordance, upgrading and downgrading were 49.7, 15.1 and 35.2%, respectively. The combined effect of SB + TB resulted in a lower upgrading rate, relative to TB and SB (both <i>p</i> < 0.001), but a higher downgrading rate, relative to TB (<i>p</i> < 0.01). Conclusions: GS obtained from TB provided higher concordance and lower upgrading and downgrading rates, relative to SB GS with regard to final pathology. The combined effect of SB + TB led to the highest concordance rate and the lowest upgrading rate. |
| first_indexed | 2024-03-10T11:21:39Z |
| format | Article |
| id | doaj.art-1c49ab2d6e23497ab2fd4f4098f2c5b3 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T11:21:39Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-1c49ab2d6e23497ab2fd4f4098f2c5b32023-11-21T19:55:58ZengMDPI AGDiagnostics2075-44182021-05-0111588210.3390/diagnostics11050882Correlation of MRI-Lesion Targeted Biopsy vs. Systematic Biopsy Gleason Score with Final Pathological Gleason Score after Radical ProstatectomyMike Wenzel0Felix Preisser1Clarissa Wittler2Benedikt Hoeh3Peter J. Wild4Alexandra Tschäbunin5Boris Bodelle6Christoph Würnschimmel7Derya Tilki8Markus Graefen9Andreas Becker10Pierre I Karakiewicz11Felix K. H. Chun12Luis A Kluth13Jens Köllermann14Philipp Mandel15Department of Urology, University Hospital Frankfurt, University Frankfurt, 60590 Frankfurt, GermanyDepartment of Urology, University Hospital Frankfurt, University Frankfurt, 60590 Frankfurt, GermanyDepartment of Urology, University Hospital Frankfurt, University Frankfurt, 60590 Frankfurt, GermanyDepartment of Urology, University Hospital Frankfurt, University Frankfurt, 60590 Frankfurt, GermanyDr. Senckenberg Institute of Pathology, University Hospital Frankfurt, 60590 Frankfurt, GermanyDr. Senckenberg Institute of Pathology, University Hospital Frankfurt, 60590 Frankfurt, GermanyDepartment of Diagnostic and Interventional Radiology, University Hospital Frankfurt, 60590 Frankfurt, GermanyCancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montreal Health Center, Montreal, QC H2X 3E4, CanadaMartini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, 20251 Hamburg, GermanyMartini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, 20251 Hamburg, GermanyDepartment of Urology, University Hospital Frankfurt, University Frankfurt, 60590 Frankfurt, GermanyCancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montreal Health Center, Montreal, QC H2X 3E4, CanadaDepartment of Urology, University Hospital Frankfurt, University Frankfurt, 60590 Frankfurt, GermanyDepartment of Urology, University Hospital Frankfurt, University Frankfurt, 60590 Frankfurt, GermanyDr. Senckenberg Institute of Pathology, University Hospital Frankfurt, 60590 Frankfurt, GermanyDepartment of Urology, University Hospital Frankfurt, University Frankfurt, 60590 Frankfurt, GermanyBackground: The impact of MRI-lesion targeted (TB) and systematic biopsy (SB) Gleason score (GS) as a predictor for final pathological GS still remains unclear. Methods: All patients with TB + SB, and subsequent radical prostatectomy (RP) between 01/2014-12/2020 were analyzed. Rank correlation coefficient predicted concordance with pathological GS for patients’ TB and SB GS, as well as for the combined effect of SB + TB. Results: Of 159 eligible patients, 77% were biopsy naïve. For SB taken in addition to TB, a Spearman’s correlation of +0.33 was observed regarding final GS. Rates of concordance, upgrading, and downgrading were 37.1, 37.1 and 25.8%, respectively. For TB, a +0.52 correlation was computed regarding final GS. Rates of concordance, upgrading and downgrading for TB biopsy GS were 45.9, 33.3, and 20.8%, respectively. For the combination of SB + TB, a correlation of +0.59 was observed. Rates of concordance, upgrading and downgrading were 49.7, 15.1 and 35.2%, respectively. The combined effect of SB + TB resulted in a lower upgrading rate, relative to TB and SB (both <i>p</i> < 0.001), but a higher downgrading rate, relative to TB (<i>p</i> < 0.01). Conclusions: GS obtained from TB provided higher concordance and lower upgrading and downgrading rates, relative to SB GS with regard to final pathology. The combined effect of SB + TB led to the highest concordance rate and the lowest upgrading rate.https://www.mdpi.com/2075-4418/11/5/882fusion biopsysystematic biopsyconcordanceupgradingdowngradingprostate neoplasm |
| spellingShingle | Mike Wenzel Felix Preisser Clarissa Wittler Benedikt Hoeh Peter J. Wild Alexandra Tschäbunin Boris Bodelle Christoph Würnschimmel Derya Tilki Markus Graefen Andreas Becker Pierre I Karakiewicz Felix K. H. Chun Luis A Kluth Jens Köllermann Philipp Mandel Correlation of MRI-Lesion Targeted Biopsy vs. Systematic Biopsy Gleason Score with Final Pathological Gleason Score after Radical Prostatectomy Diagnostics fusion biopsy systematic biopsy concordance upgrading downgrading prostate neoplasm |
| title | Correlation of MRI-Lesion Targeted Biopsy vs. Systematic Biopsy Gleason Score with Final Pathological Gleason Score after Radical Prostatectomy |
| title_full | Correlation of MRI-Lesion Targeted Biopsy vs. Systematic Biopsy Gleason Score with Final Pathological Gleason Score after Radical Prostatectomy |
| title_fullStr | Correlation of MRI-Lesion Targeted Biopsy vs. Systematic Biopsy Gleason Score with Final Pathological Gleason Score after Radical Prostatectomy |
| title_full_unstemmed | Correlation of MRI-Lesion Targeted Biopsy vs. Systematic Biopsy Gleason Score with Final Pathological Gleason Score after Radical Prostatectomy |
| title_short | Correlation of MRI-Lesion Targeted Biopsy vs. Systematic Biopsy Gleason Score with Final Pathological Gleason Score after Radical Prostatectomy |
| title_sort | correlation of mri lesion targeted biopsy vs systematic biopsy gleason score with final pathological gleason score after radical prostatectomy |
| topic | fusion biopsy systematic biopsy concordance upgrading downgrading prostate neoplasm |
| url | https://www.mdpi.com/2075-4418/11/5/882 |
| work_keys_str_mv | AT mikewenzel correlationofmrilesiontargetedbiopsyvssystematicbiopsygleasonscorewithfinalpathologicalgleasonscoreafterradicalprostatectomy AT felixpreisser correlationofmrilesiontargetedbiopsyvssystematicbiopsygleasonscorewithfinalpathologicalgleasonscoreafterradicalprostatectomy AT clarissawittler correlationofmrilesiontargetedbiopsyvssystematicbiopsygleasonscorewithfinalpathologicalgleasonscoreafterradicalprostatectomy AT benedikthoeh correlationofmrilesiontargetedbiopsyvssystematicbiopsygleasonscorewithfinalpathologicalgleasonscoreafterradicalprostatectomy AT peterjwild correlationofmrilesiontargetedbiopsyvssystematicbiopsygleasonscorewithfinalpathologicalgleasonscoreafterradicalprostatectomy AT alexandratschabunin correlationofmrilesiontargetedbiopsyvssystematicbiopsygleasonscorewithfinalpathologicalgleasonscoreafterradicalprostatectomy AT borisbodelle correlationofmrilesiontargetedbiopsyvssystematicbiopsygleasonscorewithfinalpathologicalgleasonscoreafterradicalprostatectomy AT christophwurnschimmel correlationofmrilesiontargetedbiopsyvssystematicbiopsygleasonscorewithfinalpathologicalgleasonscoreafterradicalprostatectomy AT deryatilki correlationofmrilesiontargetedbiopsyvssystematicbiopsygleasonscorewithfinalpathologicalgleasonscoreafterradicalprostatectomy AT markusgraefen correlationofmrilesiontargetedbiopsyvssystematicbiopsygleasonscorewithfinalpathologicalgleasonscoreafterradicalprostatectomy AT andreasbecker correlationofmrilesiontargetedbiopsyvssystematicbiopsygleasonscorewithfinalpathologicalgleasonscoreafterradicalprostatectomy AT pierreikarakiewicz correlationofmrilesiontargetedbiopsyvssystematicbiopsygleasonscorewithfinalpathologicalgleasonscoreafterradicalprostatectomy AT felixkhchun correlationofmrilesiontargetedbiopsyvssystematicbiopsygleasonscorewithfinalpathologicalgleasonscoreafterradicalprostatectomy AT luisakluth correlationofmrilesiontargetedbiopsyvssystematicbiopsygleasonscorewithfinalpathologicalgleasonscoreafterradicalprostatectomy AT jenskollermann correlationofmrilesiontargetedbiopsyvssystematicbiopsygleasonscorewithfinalpathologicalgleasonscoreafterradicalprostatectomy AT philippmandel correlationofmrilesiontargetedbiopsyvssystematicbiopsygleasonscorewithfinalpathologicalgleasonscoreafterradicalprostatectomy |