Complex and pleiotropic signaling pathways regulated by the secreted protein augurin
Abstract The secreted protein augurin, the product of the tumor suppressor gene Ecrg4, has been identified as a peptide hormone in the human proteome in 2007. Since then, a number of studies have been carried out to highlight its structure and processing and its potential roles in physiopathology. A...
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-023-01090-8 |
| _version_ | 1797845793792589824 |
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| author | Margaux Richter Enzo Lalli Carmen Ruggiero |
| author_facet | Margaux Richter Enzo Lalli Carmen Ruggiero |
| author_sort | Margaux Richter |
| collection | DOAJ |
| description | Abstract The secreted protein augurin, the product of the tumor suppressor gene Ecrg4, has been identified as a peptide hormone in the human proteome in 2007. Since then, a number of studies have been carried out to highlight its structure and processing and its potential roles in physiopathology. Although augurin has been shown to be implicated in a variety of processes, ranging from tumorigenesis, inflammation and infection to neural stem cell proliferation, hypothalamo-pituitary adrenal axis regulation and osteoblast differentiation, the molecular mechanisms of its biological effects and the signaling pathways it regulates are still poorly characterized. Here we provide a comprehensive overview of augurin-dependent signal transduction pathways. Because of their secreted nature and the potential to be manipulated pharmacologically, augurin and its derived peptides represent attractive targets for diagnostic development and discovery of new therapeutic agents for the human diseases resulting from the deregulation of the signaling cascades they modulate. From this perspective, the characterization of the precise nature of augurin derived peptides and the identification of the receptor(s) on the cell surface conveying augurin signaling to downstream effectors are crucial to develop agonists and antagonists for this protein. Video abstract |
| first_indexed | 2024-04-09T17:45:43Z |
| format | Article |
| id | doaj.art-1c49ec2d96364899a03a39c2c29789f2 |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-04-09T17:45:43Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-1c49ec2d96364899a03a39c2c29789f22023-04-16T11:20:20ZengBMCCell Communication and Signaling1478-811X2023-04-0121111110.1186/s12964-023-01090-8Complex and pleiotropic signaling pathways regulated by the secreted protein augurinMargaux Richter0Enzo Lalli1Carmen Ruggiero2Institut de Pharmacologie Moleculaire et Cellulaire CNRS UMR 7275Institut de Pharmacologie Moleculaire et Cellulaire CNRS UMR 7275Institut de Pharmacologie Moleculaire et Cellulaire CNRS UMR 7275Abstract The secreted protein augurin, the product of the tumor suppressor gene Ecrg4, has been identified as a peptide hormone in the human proteome in 2007. Since then, a number of studies have been carried out to highlight its structure and processing and its potential roles in physiopathology. Although augurin has been shown to be implicated in a variety of processes, ranging from tumorigenesis, inflammation and infection to neural stem cell proliferation, hypothalamo-pituitary adrenal axis regulation and osteoblast differentiation, the molecular mechanisms of its biological effects and the signaling pathways it regulates are still poorly characterized. Here we provide a comprehensive overview of augurin-dependent signal transduction pathways. Because of their secreted nature and the potential to be manipulated pharmacologically, augurin and its derived peptides represent attractive targets for diagnostic development and discovery of new therapeutic agents for the human diseases resulting from the deregulation of the signaling cascades they modulate. From this perspective, the characterization of the precise nature of augurin derived peptides and the identification of the receptor(s) on the cell surface conveying augurin signaling to downstream effectors are crucial to develop agonists and antagonists for this protein. Video abstracthttps://doi.org/10.1186/s12964-023-01090-8ECRG4AugurinSignal transductionPeptides |
| spellingShingle | Margaux Richter Enzo Lalli Carmen Ruggiero Complex and pleiotropic signaling pathways regulated by the secreted protein augurin Cell Communication and Signaling ECRG4 Augurin Signal transduction Peptides |
| title | Complex and pleiotropic signaling pathways regulated by the secreted protein augurin |
| title_full | Complex and pleiotropic signaling pathways regulated by the secreted protein augurin |
| title_fullStr | Complex and pleiotropic signaling pathways regulated by the secreted protein augurin |
| title_full_unstemmed | Complex and pleiotropic signaling pathways regulated by the secreted protein augurin |
| title_short | Complex and pleiotropic signaling pathways regulated by the secreted protein augurin |
| title_sort | complex and pleiotropic signaling pathways regulated by the secreted protein augurin |
| topic | ECRG4 Augurin Signal transduction Peptides |
| url | https://doi.org/10.1186/s12964-023-01090-8 |
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