Relationship between rs3918242 Polymorphism of Matrix Methaloproteinase-9 Gene and Preeclampsia in Pregnant Women
Background Preeclampsia is a complex disorder of pregnancy with an unknown etiology. Numerous studies have shown the possible role of gene polymorphisms, especially metalloproteinases, in development of this disease, but there are no definitive results. Objective This study aims to investigate th...
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| Format: | Article |
| Language: | fas |
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Qazvin University of Medical Sciences & Health Services
2021-01-01
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| Series: | The Journal of Qazvin University of Medical Sciences |
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| Online Access: | https://journal.qums.ac.ir/article-1-3066-en.html |
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| author | Mehdi Sahmani Nilofar Ahmadi Somayeh Asadian Talaat Dabaghi Ghaleh Amir Javadi |
| author_facet | Mehdi Sahmani Nilofar Ahmadi Somayeh Asadian Talaat Dabaghi Ghaleh Amir Javadi |
| author_sort | Mehdi Sahmani |
| collection | DOAJ |
| description | Background Preeclampsia is a complex disorder of pregnancy with an unknown etiology. Numerous
studies have shown the possible role of gene polymorphisms, especially metalloproteinases, in development
of this disease, but there are no definitive results.
Objective This study aims to investigate the possible association between rs3918242 (−1562C>T) polymorphism
in Matrix Metalloproteinase 9 (MMP9) gene with the risk of preeclampsia in pregnant women.
Methods In this cross-sectional study, participants were 90 pregnant women with preeclampsia and 199
healthy pregnant women (controls). The genotypes of rs3918242 polymorphism were investigated using
Polymerase Chain Reaction technique and Limited Fragment Length Polymorphism method. Logistic
regression analysis was used to investigate the relationship between rs3918242 polymorphism and
preeclampsia.
Findings The frequency of CC, CT, TT genotypes of rs3918242 polymorphism was reported 47.8%, 47.8%
and 4.2% in patients and 84.8, 13.1 and 2% in controls, respectively, and the difference between groups
was significant (P<0.001). The frequency of TT genotype in patients was significantly higher than in controls
(P<0.001). Moreover, the frequency of T allele in patients was 52.2%, while in controls it was 15.2%
and the difference between the two groups was significant (P<0.001).
Conclusion The rs3918242 polymorphism of MMP9 gene plays an important role in the incidence of
preeclampsia in pregnant women. |
| first_indexed | 2024-12-13T21:02:15Z |
| format | Article |
| id | doaj.art-1c4c7bd5908149c3a414293c4ed6df45 |
| institution | Directory Open Access Journal |
| issn | 1561-3666 2228-7213 |
| language | fas |
| last_indexed | 2024-12-13T21:02:15Z |
| publishDate | 2021-01-01 |
| publisher | Qazvin University of Medical Sciences & Health Services |
| record_format | Article |
| series | The Journal of Qazvin University of Medical Sciences |
| spelling | doaj.art-1c4c7bd5908149c3a414293c4ed6df452022-12-21T23:31:34ZfasQazvin University of Medical Sciences & Health ServicesThe Journal of Qazvin University of Medical Sciences1561-36662228-72132021-01-01245434443https://doi.org/10.32598/JQUMS.24.5.6Relationship between rs3918242 Polymorphism of Matrix Methaloproteinase-9 Gene and Preeclampsia in Pregnant WomenMehdi Sahmanihttps://orcid.org/0000-0002-0069-8803Nilofar Ahmadihttps://orcid.org/0000-0002-8680-8849Somayeh Asadianhttps://orcid.org/0000-0002-6000-2089Talaat Dabaghi GhalehAmir Javadihttps://orcid.org/0000-0001-7715-4583Background Preeclampsia is a complex disorder of pregnancy with an unknown etiology. Numerous studies have shown the possible role of gene polymorphisms, especially metalloproteinases, in development of this disease, but there are no definitive results. Objective This study aims to investigate the possible association between rs3918242 (−1562C>T) polymorphism in Matrix Metalloproteinase 9 (MMP9) gene with the risk of preeclampsia in pregnant women. Methods In this cross-sectional study, participants were 90 pregnant women with preeclampsia and 199 healthy pregnant women (controls). The genotypes of rs3918242 polymorphism were investigated using Polymerase Chain Reaction technique and Limited Fragment Length Polymorphism method. Logistic regression analysis was used to investigate the relationship between rs3918242 polymorphism and preeclampsia. Findings The frequency of CC, CT, TT genotypes of rs3918242 polymorphism was reported 47.8%, 47.8% and 4.2% in patients and 84.8, 13.1 and 2% in controls, respectively, and the difference between groups was significant (P<0.001). The frequency of TT genotype in patients was significantly higher than in controls (P<0.001). Moreover, the frequency of T allele in patients was 52.2%, while in controls it was 15.2% and the difference between the two groups was significant (P<0.001). Conclusion The rs3918242 polymorphism of MMP9 gene plays an important role in the incidence of preeclampsia in pregnant women.https://journal.qums.ac.ir/article-1-3066-en.htmlpreeclampsiars3918242 polymorphismmatrix metalloproteinase 9 |
| spellingShingle | Mehdi Sahmani Nilofar Ahmadi Somayeh Asadian Talaat Dabaghi Ghaleh Amir Javadi Relationship between rs3918242 Polymorphism of Matrix Methaloproteinase-9 Gene and Preeclampsia in Pregnant Women The Journal of Qazvin University of Medical Sciences preeclampsia rs3918242 polymorphism matrix metalloproteinase 9 |
| title | Relationship between rs3918242 Polymorphism of Matrix Methaloproteinase-9 Gene and Preeclampsia in Pregnant Women |
| title_full | Relationship between rs3918242 Polymorphism of Matrix Methaloproteinase-9 Gene and Preeclampsia in Pregnant Women |
| title_fullStr | Relationship between rs3918242 Polymorphism of Matrix Methaloproteinase-9 Gene and Preeclampsia in Pregnant Women |
| title_full_unstemmed | Relationship between rs3918242 Polymorphism of Matrix Methaloproteinase-9 Gene and Preeclampsia in Pregnant Women |
| title_short | Relationship between rs3918242 Polymorphism of Matrix Methaloproteinase-9 Gene and Preeclampsia in Pregnant Women |
| title_sort | relationship between rs3918242 polymorphism of matrix methaloproteinase 9 gene and preeclampsia in pregnant women |
| topic | preeclampsia rs3918242 polymorphism matrix metalloproteinase 9 |
| url | https://journal.qums.ac.ir/article-1-3066-en.html |
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