Measuring episodic verbal learning ability in alcohol-related cognitive disorders in relation to everyday functioning
Adequate and timely assessment of learning abilities in individuals with alcohol-related cognitive disorders is highly relevant to optimize addiction care. Learning curves of episodic verbal memory tests have been used to assess learning ability in various neurocognitive disorders, but studies in al...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Addiction Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772392524000038 |
| _version_ | 1797339129469468672 |
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| author | Willem S. Eikelboom William F. Goette Yvonne C.M. Rensen Jurriaan C. van Nuland Gwenny T.L. Janssen Roy P.C. Kessels |
| author_facet | Willem S. Eikelboom William F. Goette Yvonne C.M. Rensen Jurriaan C. van Nuland Gwenny T.L. Janssen Roy P.C. Kessels |
| author_sort | Willem S. Eikelboom |
| collection | DOAJ |
| description | Adequate and timely assessment of learning abilities in individuals with alcohol-related cognitive disorders is highly relevant to optimize addiction care. Learning curves of episodic verbal memory tests have been used to assess learning ability in various neurocognitive disorders, but studies in alcohol-related cognitive disorders are lacking. Therefore, this study investigated California Verbal Learning Test (CVLT) learning curves in individuals with alcohol-use disorder (AUD) with and without cognitive impairments and examined associations between learning curves and changes in everyday functioning following a multicomponent care program. We fitted learning curves over the five immediate recall trials of the Dutch version of the CVLT of patients with Korsakoff's syndrome (KS; N = 117), alcohol-related cognitive impairment no KS (ARCI; N = 147), and uncomplicated AUD (N = 43) using a generalized non-linear mixed regression. This model was based on three different parameters: initial memory performance (attention), maximum number of correctly recalled words (maximum learning), and the increase of correctly recalled words over the trials (learning rate). Next, we related these learning curves with ratings of everyday activities using the Patient Competency Rating Scale (PCRS) before and after a care program following admission. Modelled learning curves differed across groups, with significant differences in Attention (KS<ARCI<AUD, p < 0.001), Maximum Learning (KS<ARCI<AUD, p<0.001), and Learning Rate (KS<ARCI=AUD, p < 0.001). However, modelled learning curves were not related to reliable improvement in PCRS scores (p>0.05). Although modelled learning curves may be used to differentiate diagnostic groups in alcohol-related cognitive disorders, future studies are needed to establish the criterion validity of learning curves in this population. |
| first_indexed | 2024-03-08T09:41:27Z |
| format | Article |
| id | doaj.art-1c4c82a3332c46298485371dec8c33b7 |
| institution | Directory Open Access Journal |
| issn | 2772-3925 |
| language | English |
| last_indexed | 2024-03-08T09:41:27Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Addiction Neuroscience |
| spelling | doaj.art-1c4c82a3332c46298485371dec8c33b72024-01-30T04:18:58ZengElsevierAddiction Neuroscience2772-39252024-06-0111100144Measuring episodic verbal learning ability in alcohol-related cognitive disorders in relation to everyday functioningWillem S. Eikelboom0William F. Goette1Yvonne C.M. Rensen2Jurriaan C. van Nuland3Gwenny T.L. Janssen4Roy P.C. Kessels5Centre of Excellence for Korsakoff and Alcohol-Related Cognitive Disorders, Vincent van Gogh Institute for Psychiatry, Venray, the Netherlands; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands; Corresponding author at: Vincent van Gogh Institute for Psychiatry, Center of Excellence for Korsakoff and Alcohol-Related Cognitive Disorders, D'n Herk 90, Venray 5803 DN, the Netherlands.Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USACentre of Excellence for Korsakoff and Alcohol-Related Cognitive Disorders, Vincent van Gogh Institute for Psychiatry, Venray, the NetherlandsCentre of Excellence for Korsakoff and Alcohol-Related Cognitive Disorders, Vincent van Gogh Institute for Psychiatry, Venray, the Netherlands; Tactus Addiction Care, Deventer, the NetherlandsCentre of Excellence for Korsakoff and Alcohol-Related Cognitive Disorders, Vincent van Gogh Institute for Psychiatry, Venray, the NetherlandsCentre of Excellence for Korsakoff and Alcohol-Related Cognitive Disorders, Vincent van Gogh Institute for Psychiatry, Venray, the Netherlands; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands; Tactus Addiction Care, Deventer, the NetherlandsAdequate and timely assessment of learning abilities in individuals with alcohol-related cognitive disorders is highly relevant to optimize addiction care. Learning curves of episodic verbal memory tests have been used to assess learning ability in various neurocognitive disorders, but studies in alcohol-related cognitive disorders are lacking. Therefore, this study investigated California Verbal Learning Test (CVLT) learning curves in individuals with alcohol-use disorder (AUD) with and without cognitive impairments and examined associations between learning curves and changes in everyday functioning following a multicomponent care program. We fitted learning curves over the five immediate recall trials of the Dutch version of the CVLT of patients with Korsakoff's syndrome (KS; N = 117), alcohol-related cognitive impairment no KS (ARCI; N = 147), and uncomplicated AUD (N = 43) using a generalized non-linear mixed regression. This model was based on three different parameters: initial memory performance (attention), maximum number of correctly recalled words (maximum learning), and the increase of correctly recalled words over the trials (learning rate). Next, we related these learning curves with ratings of everyday activities using the Patient Competency Rating Scale (PCRS) before and after a care program following admission. Modelled learning curves differed across groups, with significant differences in Attention (KS<ARCI<AUD, p < 0.001), Maximum Learning (KS<ARCI<AUD, p<0.001), and Learning Rate (KS<ARCI=AUD, p < 0.001). However, modelled learning curves were not related to reliable improvement in PCRS scores (p>0.05). Although modelled learning curves may be used to differentiate diagnostic groups in alcohol-related cognitive disorders, future studies are needed to establish the criterion validity of learning curves in this population.http://www.sciencedirect.com/science/article/pii/S2772392524000038Korsakoff's syndromeWernicke's encephalopathyMemoryLearning |
| spellingShingle | Willem S. Eikelboom William F. Goette Yvonne C.M. Rensen Jurriaan C. van Nuland Gwenny T.L. Janssen Roy P.C. Kessels Measuring episodic verbal learning ability in alcohol-related cognitive disorders in relation to everyday functioning Addiction Neuroscience Korsakoff's syndrome Wernicke's encephalopathy Memory Learning |
| title | Measuring episodic verbal learning ability in alcohol-related cognitive disorders in relation to everyday functioning |
| title_full | Measuring episodic verbal learning ability in alcohol-related cognitive disorders in relation to everyday functioning |
| title_fullStr | Measuring episodic verbal learning ability in alcohol-related cognitive disorders in relation to everyday functioning |
| title_full_unstemmed | Measuring episodic verbal learning ability in alcohol-related cognitive disorders in relation to everyday functioning |
| title_short | Measuring episodic verbal learning ability in alcohol-related cognitive disorders in relation to everyday functioning |
| title_sort | measuring episodic verbal learning ability in alcohol related cognitive disorders in relation to everyday functioning |
| topic | Korsakoff's syndrome Wernicke's encephalopathy Memory Learning |
| url | http://www.sciencedirect.com/science/article/pii/S2772392524000038 |
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