Polymorphisms in Processing and Antigen Presentation-Related Genes and Their Association with Host Susceptibility to Influenza A/H1N1 2009 Pandemic in a Mexican Mestizo Population
(1) Background: The influenza A/H1N1 pdm09 virus rapidly spread throughout the world. Despite the inflammatory and virus-degradation pathways described in the pathogenesis of influenza A virus (IAV) infection, little is known about the role of the single nucleotide polymorphisms (SNPs) in the genes...
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| Format: | Article |
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MDPI AG
2020-10-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/12/11/1224 |
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| author | Marco Antonio Ponce-Gallegos Aseneth Ruiz-Celis Enrique Ambrocio-Ortiz Gloria Pérez-Rubio Alejandra Ramírez-Venegas Nora E. Bautista-Félix Ramcés Falfán-Valencia |
| author_facet | Marco Antonio Ponce-Gallegos Aseneth Ruiz-Celis Enrique Ambrocio-Ortiz Gloria Pérez-Rubio Alejandra Ramírez-Venegas Nora E. Bautista-Félix Ramcés Falfán-Valencia |
| author_sort | Marco Antonio Ponce-Gallegos |
| collection | DOAJ |
| description | (1) Background: The influenza A/H1N1 pdm09 virus rapidly spread throughout the world. Despite the inflammatory and virus-degradation pathways described in the pathogenesis of influenza A virus (IAV) infection, little is known about the role of the single nucleotide polymorphisms (SNPs) in the genes involved in the processing and antigenic presentation-related mechanisms. (2) Methods: In this case-control study, we evaluated 17 SNPs in five genes (<i>TAP1</i>, <i>TAP2</i>, <i>TAPBP</i>, <i>PSMB8</i>, and <i>PSMB9</i>). One hundred and twenty-eight patients with influenza A/H1N1 infection (INF-P) and 111 healthy contacts (HC) were included; all of them are Mexican mestizo. (3) Results: In allele and genotype comparison, the rs241433/C allele (<i>TAP2</i>), as well as AG haplotype (rs3763365 and rs4148882), are associated with reduced risk for influenza A/H1N1 infection (<i>p</i> < 0.05). On the other hand, the rs2071888G allele (<i>TAPBP</i>) and GG haplotype (rs3763365 and rs9276810) are associated with a higher risk for influenza A/H1N1 infection. In addition, after adjustment for covariates, the association to a reduced risk for influenza A/H1N1 infection remains with rs241433/C allele (<i>p</i> < 0.0001, OR = 0.24, 95% CI = 0.13–0.43), and the association with <i>TAPBP</i> is also maintained with the G allele (<i>p</i> = 0.0095, OR = 1.89, 95% CI = 1.17–3.06) and GG genotype models (<i>p</i> < 0.05, OR = 2.18, 95% CI = 1.27–3.74). (4) Conclusion: The rs241433/C allele and AC genotype (<i>TAP2</i>) and the AG haplotype are associated with a reduced risk for influenza A/H1N1 infection. In addition, the rs2071888/G allele and GG genotype (<i>TAPBP</i>) and the GG haplotype are associated with a higher risk for developing influenza A/H1N1 infection in a Mexican mestizo population. |
| first_indexed | 2024-03-10T15:14:34Z |
| format | Article |
| id | doaj.art-1c4d29d98a9a42e8b7512688f3546730 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T15:14:34Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-1c4d29d98a9a42e8b7512688f35467302023-11-20T19:00:37ZengMDPI AGViruses1999-49152020-10-011211122410.3390/v12111224Polymorphisms in Processing and Antigen Presentation-Related Genes and Their Association with Host Susceptibility to Influenza A/H1N1 2009 Pandemic in a Mexican Mestizo PopulationMarco Antonio Ponce-Gallegos0Aseneth Ruiz-Celis1Enrique Ambrocio-Ortiz2Gloria Pérez-Rubio3Alejandra Ramírez-Venegas4Nora E. Bautista-Félix5Ramcés Falfán-Valencia6HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City 14080, MexicoHLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City 14080, MexicoHLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City 14080, MexicoHLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City 14080, MexicoTobacco Smoking and COPD Research Department, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City 14080, MexicoTobacco Smoking and COPD Research Department, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City 14080, MexicoHLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City 14080, Mexico(1) Background: The influenza A/H1N1 pdm09 virus rapidly spread throughout the world. Despite the inflammatory and virus-degradation pathways described in the pathogenesis of influenza A virus (IAV) infection, little is known about the role of the single nucleotide polymorphisms (SNPs) in the genes involved in the processing and antigenic presentation-related mechanisms. (2) Methods: In this case-control study, we evaluated 17 SNPs in five genes (<i>TAP1</i>, <i>TAP2</i>, <i>TAPBP</i>, <i>PSMB8</i>, and <i>PSMB9</i>). One hundred and twenty-eight patients with influenza A/H1N1 infection (INF-P) and 111 healthy contacts (HC) were included; all of them are Mexican mestizo. (3) Results: In allele and genotype comparison, the rs241433/C allele (<i>TAP2</i>), as well as AG haplotype (rs3763365 and rs4148882), are associated with reduced risk for influenza A/H1N1 infection (<i>p</i> < 0.05). On the other hand, the rs2071888G allele (<i>TAPBP</i>) and GG haplotype (rs3763365 and rs9276810) are associated with a higher risk for influenza A/H1N1 infection. In addition, after adjustment for covariates, the association to a reduced risk for influenza A/H1N1 infection remains with rs241433/C allele (<i>p</i> < 0.0001, OR = 0.24, 95% CI = 0.13–0.43), and the association with <i>TAPBP</i> is also maintained with the G allele (<i>p</i> = 0.0095, OR = 1.89, 95% CI = 1.17–3.06) and GG genotype models (<i>p</i> < 0.05, OR = 2.18, 95% CI = 1.27–3.74). (4) Conclusion: The rs241433/C allele and AC genotype (<i>TAP2</i>) and the AG haplotype are associated with a reduced risk for influenza A/H1N1 infection. In addition, the rs2071888/G allele and GG genotype (<i>TAPBP</i>) and the GG haplotype are associated with a higher risk for developing influenza A/H1N1 infection in a Mexican mestizo population.https://www.mdpi.com/1999-4915/12/11/1224influenza A/H1N1 pdm09<i>TAP2</i><i>TAPBP</i><i>PSMB8</i>host susceptibility |
| spellingShingle | Marco Antonio Ponce-Gallegos Aseneth Ruiz-Celis Enrique Ambrocio-Ortiz Gloria Pérez-Rubio Alejandra Ramírez-Venegas Nora E. Bautista-Félix Ramcés Falfán-Valencia Polymorphisms in Processing and Antigen Presentation-Related Genes and Their Association with Host Susceptibility to Influenza A/H1N1 2009 Pandemic in a Mexican Mestizo Population Viruses influenza A/H1N1 pdm09 <i>TAP2</i> <i>TAPBP</i> <i>PSMB8</i> host susceptibility |
| title | Polymorphisms in Processing and Antigen Presentation-Related Genes and Their Association with Host Susceptibility to Influenza A/H1N1 2009 Pandemic in a Mexican Mestizo Population |
| title_full | Polymorphisms in Processing and Antigen Presentation-Related Genes and Their Association with Host Susceptibility to Influenza A/H1N1 2009 Pandemic in a Mexican Mestizo Population |
| title_fullStr | Polymorphisms in Processing and Antigen Presentation-Related Genes and Their Association with Host Susceptibility to Influenza A/H1N1 2009 Pandemic in a Mexican Mestizo Population |
| title_full_unstemmed | Polymorphisms in Processing and Antigen Presentation-Related Genes and Their Association with Host Susceptibility to Influenza A/H1N1 2009 Pandemic in a Mexican Mestizo Population |
| title_short | Polymorphisms in Processing and Antigen Presentation-Related Genes and Their Association with Host Susceptibility to Influenza A/H1N1 2009 Pandemic in a Mexican Mestizo Population |
| title_sort | polymorphisms in processing and antigen presentation related genes and their association with host susceptibility to influenza a h1n1 2009 pandemic in a mexican mestizo population |
| topic | influenza A/H1N1 pdm09 <i>TAP2</i> <i>TAPBP</i> <i>PSMB8</i> host susceptibility |
| url | https://www.mdpi.com/1999-4915/12/11/1224 |
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