Pharmacological Inhibition of S-Nitrosoglutathione Reductase Reduces Cardiac Damage Induced by Ischemia–Reperfusion

Pharmacological Inhibition of S-Nitrosoglutathione Reductase Reduces Cardiac Damage Induced by Ischemia–Reperfusion

The cardioprotective effects of nitric oxide (NO) have been described through S-nitrosylation of several important proteins in the mitochondria of the cardiomyocyte. S-nitrosoglutathione reductase (GSNOR) is an enzyme involved in the metabolism of S-nitrosothiols by producing denitrosylation, thus l...

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Bibliographic Details
Main Authors: Oscar Arriagada Castillo, Gustavo Herrera, Carlos Manriquez, Andrea F. Rojas, Daniel R. González
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Antioxidants
Subjects:
S-nitrosylation
heart
GSNOR
mitochondria
Online Access:https://www.mdpi.com/2076-3921/10/4/555

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