The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer
Here the authors describe multiple structures of the replicative helicase MCM2-7 in complex with Dbf4-dependent kinase (DDK). These structures reveal why the kinase specifically recognizes the MCM2-7 double-hexamer over the single-hexamer and explain how DDK can phosphorylate distantly located Mcm t...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30576-1 |
| _version_ | 1811324478200741888 |
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| author | Almutasem Saleh Yasunori Noguchi Ricardo Aramayo Marina E. Ivanova Kathryn M. Stevens Alex Montoya S. Sunidhi Nicolas Lopez Carranza Marcin J. Skwark Christian Speck |
| author_facet | Almutasem Saleh Yasunori Noguchi Ricardo Aramayo Marina E. Ivanova Kathryn M. Stevens Alex Montoya S. Sunidhi Nicolas Lopez Carranza Marcin J. Skwark Christian Speck |
| author_sort | Almutasem Saleh |
| collection | DOAJ |
| description | Here the authors describe multiple structures of the replicative helicase MCM2-7 in complex with Dbf4-dependent kinase (DDK). These structures reveal why the kinase specifically recognizes the MCM2-7 double-hexamer over the single-hexamer and explain how DDK can phosphorylate distantly located Mcm tails. |
| first_indexed | 2024-04-13T14:14:59Z |
| format | Article |
| id | doaj.art-1c4e6e876ce4469480a77bd86fddffbb |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T14:14:59Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-1c4e6e876ce4469480a77bd86fddffbb2022-12-22T02:43:40ZengNature PortfolioNature Communications2041-17232022-05-0113112010.1038/s41467-022-30576-1The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamerAlmutasem Saleh0Yasunori Noguchi1Ricardo Aramayo2Marina E. Ivanova3Kathryn M. Stevens4Alex Montoya5S. Sunidhi6Nicolas Lopez Carranza7Marcin J. Skwark8Christian Speck9DNA Replication Group, Institute of Clinical Sciences, Faculty of Medicine, Imperial College LondonDNA Replication Group, Institute of Clinical Sciences, Faculty of Medicine, Imperial College LondonDNA Replication Group, Institute of Clinical Sciences, Faculty of Medicine, Imperial College LondonDNA Replication Group, Institute of Clinical Sciences, Faculty of Medicine, Imperial College LondonDNA Replication Group, Institute of Clinical Sciences, Faculty of Medicine, Imperial College LondonProteomics and Metabolomics Facility, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital CampusInstaDeep Ltd, 5 Merchant SquareInstaDeep Ltd, 5 Merchant SquareInstaDeep Ltd, 5 Merchant SquareDNA Replication Group, Institute of Clinical Sciences, Faculty of Medicine, Imperial College LondonHere the authors describe multiple structures of the replicative helicase MCM2-7 in complex with Dbf4-dependent kinase (DDK). These structures reveal why the kinase specifically recognizes the MCM2-7 double-hexamer over the single-hexamer and explain how DDK can phosphorylate distantly located Mcm tails.https://doi.org/10.1038/s41467-022-30576-1 |
| spellingShingle | Almutasem Saleh Yasunori Noguchi Ricardo Aramayo Marina E. Ivanova Kathryn M. Stevens Alex Montoya S. Sunidhi Nicolas Lopez Carranza Marcin J. Skwark Christian Speck The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer Nature Communications |
| title | The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer |
| title_full | The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer |
| title_fullStr | The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer |
| title_full_unstemmed | The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer |
| title_short | The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer |
| title_sort | structural basis of cdc7 dbf4 kinase dependent targeting and phosphorylation of the mcm2 7 double hexamer |
| url | https://doi.org/10.1038/s41467-022-30576-1 |
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