Predicting the Severity of Esophageal Varices in Patients with Hepatic Cirrhosis Using Non-Invasive Markers
Yang-Chun Du,1,2,* Dan Jiang,3,* Ji Wu1 1Department of Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, People’s Republic of China; 2Department of Ultrasound, The People’s Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of M...
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| Format: | Article |
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Dove Medical Press
2023-08-01
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| Series: | Risk Management and Healthcare Policy |
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| Online Access: | https://www.dovepress.com/predicting-the-severity-of-esophageal-varices-in-patients-with-hepatic-peer-reviewed-fulltext-article-RMHP |
| _version_ | 1797742649915998208 |
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| author | Du YC Jiang D Wu J |
| author_facet | Du YC Jiang D Wu J |
| author_sort | Du YC |
| collection | DOAJ |
| description | Yang-Chun Du,1,2,* Dan Jiang,3,* Ji Wu1 1Department of Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, People’s Republic of China; 2Department of Ultrasound, The People’s Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences, Nanning, 530021, People’s Republic of China; 3Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ji Wu, Department of Ultrasound, The First Affiliated Hospital of Guangxi Medical University, No. 6 of Shuangyong Road, Qingxiu District, Nanning, 530021, People’s Republic of China, Tel +86 13978862109, Email gxnnwuji@163.comBackground: The presence and extent of severity of esophageal varices (EV) in patients with liver cirrhosis (LC) are predicted using noninvasive clinical, biochemical, and imaging parameters. The aim of this study was to investigate the accuracy of noninvasive predictors of EV, such as the platelet count-to-spleen diameter ratio (PSR), platelet count-to-spleen volume ratio (PSVR), spleen size (SZ), and a combination of these markers in determining the severity of EV in patients with cirrhosis.Methods: We recruited 82 inpatients with LC from the Department of Gastroenterology at the First Affiliated Hospital of Guangxi Medical University between January 2018 and December 2019 for this diagnostic investigation. All patients underwent endoscopy, ultrasound, computed tomography, and routine laboratory investigations. For the study, we evaluated and compared the diagnostic accuracy of PSR, PSVR, SZ, and their combinations.Results: There were significant differences in the area under the receiver operating characteristic (ROC) curve (AUC) in the prediction of severe and moderate/severe EV for all the variables. PSR+PSVR had the highest AUC at 0.735 (95% CI: 0.626– 0.826) and 0.765 (95% CI: 0.659– 0.852) for predicting severe and moderate/severe EV, respectively. There were statistically significant differences in the AUCs (95% CI) for PSR, PSVR, and PSR+PSVR in predicting the existence of EV. As per the overall model quality chart, the combination of PSR+PSVR was the best indicator for detecting the presence of EV (AUC, 0.696; 95% CI: 0.584– 0.792).Conclusion: In our study, we found that these noninvasive parameters could predict the extent of severity of EV in patients with LC. We anticipate the use of a combination of PSR + PSVR to emerge as the superior indicator as studies progress.Keywords: esophageal varices, liver cirrhosis, noninvasive predictors, platelet count-to-spleen diameter ratio, platelet count-to-spleen volume ratio, spleen size |
| first_indexed | 2024-03-12T14:43:38Z |
| format | Article |
| id | doaj.art-1c4f266d68cb498db04e687390920851 |
| institution | Directory Open Access Journal |
| issn | 1179-1594 |
| language | English |
| last_indexed | 2024-03-12T14:43:38Z |
| publishDate | 2023-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Risk Management and Healthcare Policy |
| spelling | doaj.art-1c4f266d68cb498db04e6873909208512023-08-16T02:32:30ZengDove Medical PressRisk Management and Healthcare Policy1179-15942023-08-01Volume 161555156685940Predicting the Severity of Esophageal Varices in Patients with Hepatic Cirrhosis Using Non-Invasive MarkersDu YCJiang DWu JYang-Chun Du,1,2,* Dan Jiang,3,* Ji Wu1 1Department of Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, People’s Republic of China; 2Department of Ultrasound, The People’s Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences, Nanning, 530021, People’s Republic of China; 3Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ji Wu, Department of Ultrasound, The First Affiliated Hospital of Guangxi Medical University, No. 6 of Shuangyong Road, Qingxiu District, Nanning, 530021, People’s Republic of China, Tel +86 13978862109, Email gxnnwuji@163.comBackground: The presence and extent of severity of esophageal varices (EV) in patients with liver cirrhosis (LC) are predicted using noninvasive clinical, biochemical, and imaging parameters. The aim of this study was to investigate the accuracy of noninvasive predictors of EV, such as the platelet count-to-spleen diameter ratio (PSR), platelet count-to-spleen volume ratio (PSVR), spleen size (SZ), and a combination of these markers in determining the severity of EV in patients with cirrhosis.Methods: We recruited 82 inpatients with LC from the Department of Gastroenterology at the First Affiliated Hospital of Guangxi Medical University between January 2018 and December 2019 for this diagnostic investigation. All patients underwent endoscopy, ultrasound, computed tomography, and routine laboratory investigations. For the study, we evaluated and compared the diagnostic accuracy of PSR, PSVR, SZ, and their combinations.Results: There were significant differences in the area under the receiver operating characteristic (ROC) curve (AUC) in the prediction of severe and moderate/severe EV for all the variables. PSR+PSVR had the highest AUC at 0.735 (95% CI: 0.626– 0.826) and 0.765 (95% CI: 0.659– 0.852) for predicting severe and moderate/severe EV, respectively. There were statistically significant differences in the AUCs (95% CI) for PSR, PSVR, and PSR+PSVR in predicting the existence of EV. As per the overall model quality chart, the combination of PSR+PSVR was the best indicator for detecting the presence of EV (AUC, 0.696; 95% CI: 0.584– 0.792).Conclusion: In our study, we found that these noninvasive parameters could predict the extent of severity of EV in patients with LC. We anticipate the use of a combination of PSR + PSVR to emerge as the superior indicator as studies progress.Keywords: esophageal varices, liver cirrhosis, noninvasive predictors, platelet count-to-spleen diameter ratio, platelet count-to-spleen volume ratio, spleen sizehttps://www.dovepress.com/predicting-the-severity-of-esophageal-varices-in-patients-with-hepatic-peer-reviewed-fulltext-article-RMHPesophageal varicesliver cirrhosisnoninvasive predictorsplatelet count-to-spleen diameter ratioplatelet count-to-spleen volume ratiospleen size |
| spellingShingle | Du YC Jiang D Wu J Predicting the Severity of Esophageal Varices in Patients with Hepatic Cirrhosis Using Non-Invasive Markers Risk Management and Healthcare Policy esophageal varices liver cirrhosis noninvasive predictors platelet count-to-spleen diameter ratio platelet count-to-spleen volume ratio spleen size |
| title | Predicting the Severity of Esophageal Varices in Patients with Hepatic Cirrhosis Using Non-Invasive Markers |
| title_full | Predicting the Severity of Esophageal Varices in Patients with Hepatic Cirrhosis Using Non-Invasive Markers |
| title_fullStr | Predicting the Severity of Esophageal Varices in Patients with Hepatic Cirrhosis Using Non-Invasive Markers |
| title_full_unstemmed | Predicting the Severity of Esophageal Varices in Patients with Hepatic Cirrhosis Using Non-Invasive Markers |
| title_short | Predicting the Severity of Esophageal Varices in Patients with Hepatic Cirrhosis Using Non-Invasive Markers |
| title_sort | predicting the severity of esophageal varices in patients with hepatic cirrhosis using non invasive markers |
| topic | esophageal varices liver cirrhosis noninvasive predictors platelet count-to-spleen diameter ratio platelet count-to-spleen volume ratio spleen size |
| url | https://www.dovepress.com/predicting-the-severity-of-esophageal-varices-in-patients-with-hepatic-peer-reviewed-fulltext-article-RMHP |
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