Overall Downregulation of mRNAs and Enrichment of H3K4me3 Change Near Genome-Wide Association Study Signals in Systemic Lupus Erythematosus: Cell-Specific Effects

Overall Downregulation of mRNAs and Enrichment of H3K4me3 Change Near Genome-Wide Association Study Signals in Systemic Lupus Erythematosus: Cell-Specific Effects

This study was designed to define gene expression and H3K4me3 histone modifications in T cells, B cells, and monocytes in systemic lupus erythematosus (SLE). Array studies of total peripheral blood mononuclear cells have demonstrated gene expression signatures related to neutrophils, interferon, and...

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Bibliographic Details
Main Authors: Zhe Zhang, Lihua Shi, Li Song, Kelly Maurer, Michele A. Petri, Kathleen E. Sullivan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
epigenetic
H3K4me3
ATF3
lupus
gene expression
RNA-seq
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00497/full

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