α-Synuclein-carrying astrocytic extracellular vesicles in Parkinson pathogenesis and diagnosis

α-Synuclein-carrying astrocytic extracellular vesicles in Parkinson pathogenesis and diagnosis

Abstract Background The accumulation of α-synuclein (α-syn), an essential step in PD development and progression, is observed not only in neurons but also in glia, including astrocytes. The mechanisms regulating astrocytic α-syn level and aggregation remain unclear. More recently, it has been demons...

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Bibliographic Details
Main Authors: Pan Wang, Guoyu Lan, Bin Xu, Zhenwei Yu, Chen Tian, Xia Lei, Wassilios G. Meissner, Tao Feng, Ying Yang, Jing Zhang
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Translational Neurodegeneration
Subjects:
Parkinson’s disease
Astrocyte
Extracellular vesicle
α-Synuclein
Lysosomal dysfunction
Online Access:https://doi.org/10.1186/s40035-023-00372-y

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