Turning dextran into antibacterial fibers: Quaternary ammonium salt for antibacterial treatment and wound healing
This study aims to develop new quaternary ammonium salt-based antimicrobial materials with good biocompatibility, biosafety, and strong antimicrobial properties that promote wound healing in infected wounds. First, four new quaternary ammonium salt antibacterial fibers (QASAF) are constructed: QASAF...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-06-01
|
| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535224001734 |
| _version_ | 1827256594812895232 |
|---|---|
| author | Guangyu Pan Qin Wang Hangxing Ding Jianbin Deng Shiqi Gao Liping Wang |
| author_facet | Guangyu Pan Qin Wang Hangxing Ding Jianbin Deng Shiqi Gao Liping Wang |
| author_sort | Guangyu Pan |
| collection | DOAJ |
| description | This study aims to develop new quaternary ammonium salt-based antimicrobial materials with good biocompatibility, biosafety, and strong antimicrobial properties that promote wound healing in infected wounds. First, four new quaternary ammonium salt antibacterial fibers (QASAF) are constructed: QASAF-C12, QASAF-C14, QASAF-C16, and QASAF-C18, with varying carbon chain lengths of C12, C14, C16, and C18, respectively. Then, their structure is characterized by proton nuclear magnetic resonance (NMR) analysis and their hemolytic and cytotoxic properties are also investigated. QASAFs are then evaluated for in vivo and in vitro antimicrobial performance against Staphylococcus aureus (S. aureus) and methicillin-resistant Staphylococcus aureus (MRSA). Finally, the effect of QASAF on promoting wound healing in infected wounds is evaluated using mouse wound models infected with S. aureus and MRSA. The obtained results suggest that QASAF is non-toxic to cells in the 25–125 µg/mL concentration range, is slightly hemolytic, has good biocompatibility, and has a biosafety profile. QASAF-C18 shows the best antibacterial performance against S. aureus with significant pro-healing effects on infected wounds. QASAF-C12 exhibits the best antibacterial performance against MRSA with significant pro-healing effects. The novel quaternary ammonium-based antimicrobial material provides a reference for developing antimicrobial and biocompatible wound dressings. |
| first_indexed | 2024-04-24T11:21:04Z |
| format | Article |
| id | doaj.art-1c550fb34695484caf8cd364e39675d9 |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2025-03-22T01:41:23Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-1c550fb34695484caf8cd364e39675d92024-05-09T04:35:42ZengElsevierArabian Journal of Chemistry1878-53522024-06-01176105771Turning dextran into antibacterial fibers: Quaternary ammonium salt for antibacterial treatment and wound healingGuangyu Pan0Qin Wang1Hangxing Ding2Jianbin Deng3Shiqi Gao4Liping Wang5School of Intelligent Medicine and Biotechnology, Guilin Medical University, Guilin 541199, Guangxi, China; Key Laboratory of Biochemistry and Molecular Biology, Guilin Medical University, Guilin 541199, Guangxi, ChinaSchool of Intelligent Medicine and Biotechnology, Guilin Medical University, Guilin 541199, Guangxi, China; Key Laboratory of Biochemistry and Molecular Biology, Guilin Medical University, Guilin 541199, Guangxi, ChinaSchool of Intelligent Medicine and Biotechnology, Guilin Medical University, Guilin 541199, Guangxi, China; Key Laboratory of Biochemistry and Molecular Biology, Guilin Medical University, Guilin 541199, Guangxi, ChinaSchool of Pharmacy, Guilin Medical University, Guilin 541199, Guangxi, ChinaSchool of Pharmacy, Guilin Medical University, Guilin 541199, Guangxi, ChinaSchool of Intelligent Medicine and Biotechnology, Guilin Medical University, Guilin 541199, Guangxi, China; Key Laboratory of Biochemistry and Molecular Biology, Guilin Medical University, Guilin 541199, Guangxi, China; Guangxi Engineering Research Center of Digital Medicine and Clinical Translation, Guilin Medical University, Guilin 541199, Guangxi, China; Corresponding author at: Guangxi Engineering Research Center of Digital Medicine and Clinical Translation, School of Intelligent Medicine and Biotechnology, Guilin Medical University, Guilin 541199, Guangxi, China.This study aims to develop new quaternary ammonium salt-based antimicrobial materials with good biocompatibility, biosafety, and strong antimicrobial properties that promote wound healing in infected wounds. First, four new quaternary ammonium salt antibacterial fibers (QASAF) are constructed: QASAF-C12, QASAF-C14, QASAF-C16, and QASAF-C18, with varying carbon chain lengths of C12, C14, C16, and C18, respectively. Then, their structure is characterized by proton nuclear magnetic resonance (NMR) analysis and their hemolytic and cytotoxic properties are also investigated. QASAFs are then evaluated for in vivo and in vitro antimicrobial performance against Staphylococcus aureus (S. aureus) and methicillin-resistant Staphylococcus aureus (MRSA). Finally, the effect of QASAF on promoting wound healing in infected wounds is evaluated using mouse wound models infected with S. aureus and MRSA. The obtained results suggest that QASAF is non-toxic to cells in the 25–125 µg/mL concentration range, is slightly hemolytic, has good biocompatibility, and has a biosafety profile. QASAF-C18 shows the best antibacterial performance against S. aureus with significant pro-healing effects on infected wounds. QASAF-C12 exhibits the best antibacterial performance against MRSA with significant pro-healing effects. The novel quaternary ammonium-based antimicrobial material provides a reference for developing antimicrobial and biocompatible wound dressings.http://www.sciencedirect.com/science/article/pii/S1878535224001734Antimicrobial materialsQuaternary ammonium salt antibacterial fibersStaphylococcus aureusMethicillin-resistant |
| spellingShingle | Guangyu Pan Qin Wang Hangxing Ding Jianbin Deng Shiqi Gao Liping Wang Turning dextran into antibacterial fibers: Quaternary ammonium salt for antibacterial treatment and wound healing Arabian Journal of Chemistry Antimicrobial materials Quaternary ammonium salt antibacterial fibers Staphylococcus aureus Methicillin-resistant |
| title | Turning dextran into antibacterial fibers: Quaternary ammonium salt for antibacterial treatment and wound healing |
| title_full | Turning dextran into antibacterial fibers: Quaternary ammonium salt for antibacterial treatment and wound healing |
| title_fullStr | Turning dextran into antibacterial fibers: Quaternary ammonium salt for antibacterial treatment and wound healing |
| title_full_unstemmed | Turning dextran into antibacterial fibers: Quaternary ammonium salt for antibacterial treatment and wound healing |
| title_short | Turning dextran into antibacterial fibers: Quaternary ammonium salt for antibacterial treatment and wound healing |
| title_sort | turning dextran into antibacterial fibers quaternary ammonium salt for antibacterial treatment and wound healing |
| topic | Antimicrobial materials Quaternary ammonium salt antibacterial fibers Staphylococcus aureus Methicillin-resistant |
| url | http://www.sciencedirect.com/science/article/pii/S1878535224001734 |
| work_keys_str_mv | AT guangyupan turningdextranintoantibacterialfibersquaternaryammoniumsaltforantibacterialtreatmentandwoundhealing AT qinwang turningdextranintoantibacterialfibersquaternaryammoniumsaltforantibacterialtreatmentandwoundhealing AT hangxingding turningdextranintoantibacterialfibersquaternaryammoniumsaltforantibacterialtreatmentandwoundhealing AT jianbindeng turningdextranintoantibacterialfibersquaternaryammoniumsaltforantibacterialtreatmentandwoundhealing AT shiqigao turningdextranintoantibacterialfibersquaternaryammoniumsaltforantibacterialtreatmentandwoundhealing AT lipingwang turningdextranintoantibacterialfibersquaternaryammoniumsaltforantibacterialtreatmentandwoundhealing |