"Astrocytes and microglia and their potential link with autism spectrum disorders"
The cellular mechanism(s) underlying autism spectrum disorders (ASDs) are not fully understood although it has been shown that various genetic and environmental factors contribute to their etiology. As increasing evidence indicates that astrocytes and microglial cells play a major role in synapse ma...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-02-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00021/full |
| _version_ | 1819211870114938880 |
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| author | Francesco ePetrelli Luca ePucci Paola eBezzi |
| author_facet | Francesco ePetrelli Luca ePucci Paola eBezzi |
| author_sort | Francesco ePetrelli |
| collection | DOAJ |
| description | The cellular mechanism(s) underlying autism spectrum disorders (ASDs) are not fully understood although it has been shown that various genetic and environmental factors contribute to their etiology. As increasing evidence indicates that astrocytes and microglial cells play a major role in synapse maturation and function, and there is evidence of deficits in glial cell functions in ASDs, one current hypothesis is that glial dysfunctions directly contribute to their pathophysiology. The aim of this review is to summarise microglia and astrocyte functions in synapse development and their contributions to ASDs. |
| first_indexed | 2024-12-23T06:33:56Z |
| format | Article |
| id | doaj.art-1c55532c147e44c996ca64369f80be7b |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-23T06:33:56Z |
| publishDate | 2016-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-1c55532c147e44c996ca64369f80be7b2022-12-21T17:56:51ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022016-02-011010.3389/fncel.2016.00021177723"Astrocytes and microglia and their potential link with autism spectrum disorders"Francesco ePetrelli0Luca ePucci1Paola eBezzi2UNILUNILUNILThe cellular mechanism(s) underlying autism spectrum disorders (ASDs) are not fully understood although it has been shown that various genetic and environmental factors contribute to their etiology. As increasing evidence indicates that astrocytes and microglial cells play a major role in synapse maturation and function, and there is evidence of deficits in glial cell functions in ASDs, one current hypothesis is that glial dysfunctions directly contribute to their pathophysiology. The aim of this review is to summarise microglia and astrocyte functions in synapse development and their contributions to ASDs.http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00021/fullAstrocytesMicrogliaNeurosciencesAutism spectrum disorders (ASD) |
| spellingShingle | Francesco ePetrelli Luca ePucci Paola eBezzi "Astrocytes and microglia and their potential link with autism spectrum disorders" Frontiers in Cellular Neuroscience Astrocytes Microglia Neurosciences Autism spectrum disorders (ASD) |
| title | "Astrocytes and microglia and their potential link with autism spectrum disorders" |
| title_full | "Astrocytes and microglia and their potential link with autism spectrum disorders" |
| title_fullStr | "Astrocytes and microglia and their potential link with autism spectrum disorders" |
| title_full_unstemmed | "Astrocytes and microglia and their potential link with autism spectrum disorders" |
| title_short | "Astrocytes and microglia and their potential link with autism spectrum disorders" |
| title_sort | quot astrocytes and microglia and their potential link with autism spectrum disorders quot |
| topic | Astrocytes Microglia Neurosciences Autism spectrum disorders (ASD) |
| url | http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00021/full |
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