Identification of Anti-Cancer Compounds in Medicinal Plants Using Metabolomic Approaches: A Review
The modern lifestyle despite its comfort has made cancer a second leading public health problem, following cardiovascular disease. As chemotherapeutic has many side effects including resistance, recent attention has focused on plants which may provide a good opportunity for complementary cancer trea...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | Indonesian |
| Published: |
Muhammadiyah University Press
2023-11-01
|
| Series: | Bioeksperimen: Jurnal Penelitian Biologi |
| Subjects: | |
| Online Access: | https://journals.ums.ac.id/index.php/bioeksperimen/article/view/23017 |
| _version_ | 1797243135472959488 |
|---|---|
| author | Yani Magfiroh |
| author_facet | Yani Magfiroh |
| author_sort | Yani Magfiroh |
| collection | DOAJ |
| description | The modern lifestyle despite its comfort has made cancer a second leading public health problem, following cardiovascular disease. As chemotherapeutic has many side effects including resistance, recent attention has focused on plants which may provide a good opportunity for complementary cancer treatment. Several studies have begun to focus on metabolomic research in order to discover the mechanisms of action of diverse medicinal plants, investigate biomarkers, and comprehend cancer progression at metabolic rates. This study aims to analyze and highlight related metabolomic investigations in medicinal plants that demonstrate the potential of biomarker compounds and their processes in cancer disease. The research methodology uses a literature review that is compiled from many connected journals. According to the findings, bioactive substances present in medicinal plants can be used as biomarkers to disrupt the metabolism of enzymes, transporters, and signaling pathways in cancer cells. Utilized analytical platforms include HPLC, GC-MS, FTIR and NMR. Statistical analysis employs the Anova, PCA, and OPLS-DA methods. Finally, we reviewed biomarkers of medicinal plants and metabolomic pathways, with the result that anticancer compounds may exert their activity by various methods affecting DNA replication, cell cycle, migration and apoptosis.The modern lifestyle despite its comfort has made cancer a second leading public health problem, following cardiovascular disease. As chemotherapeutic has many side effects including resistance, recent attention has focused on plants which may provide a good opportunity for complementary cancer treatment. Several studies have begun to focus on metabolomic research in order to discover the mechanisms of action of diverse medicinal plants, investigate biomarkers, and comprehend cancer progression at metabolic rates. This study aims to analyze and highlight related metabolomic investigations in medicinal plants that demonstrate the potential of biomarker compounds and their processes in cancer disease. The research methodology uses a literature review that is compiled from many connected journals. According to the findings, bioactive substances present in medicinal plants can be used as biomarkers to disrupt the metabolism of enzymes, transporters, and signaling pathways in cancer cells. Utilized analytical platforms include HPLC, GC-MS, FTIR and NMR. Statistical analysis employs the Anova, PCA, and OPLS-DA methods. Finally, we reviewed biomarkers of medicinal plants and metabolomic pathways, with the result that anticancer compounds may exert their activity by various methods affecting DNA replication, cell cycle, migration and apoptosis. |
| first_indexed | 2024-04-24T18:50:18Z |
| format | Article |
| id | doaj.art-1c564b263cb74ecca4b0e114e5ce121f |
| institution | Directory Open Access Journal |
| issn | 2460-1365 2527-2799 |
| language | Indonesian |
| last_indexed | 2024-04-24T18:50:18Z |
| publishDate | 2023-11-01 |
| publisher | Muhammadiyah University Press |
| record_format | Article |
| series | Bioeksperimen: Jurnal Penelitian Biologi |
| spelling | doaj.art-1c564b263cb74ecca4b0e114e5ce121f2024-03-27T02:00:25ZindMuhammadiyah University PressBioeksperimen: Jurnal Penelitian Biologi2460-13652527-27992023-11-019217418910.23917/bioeksperimen.v9i2.230178242Identification of Anti-Cancer Compounds in Medicinal Plants Using Metabolomic Approaches: A ReviewYani Magfiroh0Food Technology Postgraduate, Faculty of Agricultural Technology Soegijapranata Catholic University, Pawiyatan Luhur Street IV/I Bendan Duwur, Semarang 50234The modern lifestyle despite its comfort has made cancer a second leading public health problem, following cardiovascular disease. As chemotherapeutic has many side effects including resistance, recent attention has focused on plants which may provide a good opportunity for complementary cancer treatment. Several studies have begun to focus on metabolomic research in order to discover the mechanisms of action of diverse medicinal plants, investigate biomarkers, and comprehend cancer progression at metabolic rates. This study aims to analyze and highlight related metabolomic investigations in medicinal plants that demonstrate the potential of biomarker compounds and their processes in cancer disease. The research methodology uses a literature review that is compiled from many connected journals. According to the findings, bioactive substances present in medicinal plants can be used as biomarkers to disrupt the metabolism of enzymes, transporters, and signaling pathways in cancer cells. Utilized analytical platforms include HPLC, GC-MS, FTIR and NMR. Statistical analysis employs the Anova, PCA, and OPLS-DA methods. Finally, we reviewed biomarkers of medicinal plants and metabolomic pathways, with the result that anticancer compounds may exert their activity by various methods affecting DNA replication, cell cycle, migration and apoptosis.The modern lifestyle despite its comfort has made cancer a second leading public health problem, following cardiovascular disease. As chemotherapeutic has many side effects including resistance, recent attention has focused on plants which may provide a good opportunity for complementary cancer treatment. Several studies have begun to focus on metabolomic research in order to discover the mechanisms of action of diverse medicinal plants, investigate biomarkers, and comprehend cancer progression at metabolic rates. This study aims to analyze and highlight related metabolomic investigations in medicinal plants that demonstrate the potential of biomarker compounds and their processes in cancer disease. The research methodology uses a literature review that is compiled from many connected journals. According to the findings, bioactive substances present in medicinal plants can be used as biomarkers to disrupt the metabolism of enzymes, transporters, and signaling pathways in cancer cells. Utilized analytical platforms include HPLC, GC-MS, FTIR and NMR. Statistical analysis employs the Anova, PCA, and OPLS-DA methods. Finally, we reviewed biomarkers of medicinal plants and metabolomic pathways, with the result that anticancer compounds may exert their activity by various methods affecting DNA replication, cell cycle, migration and apoptosis.https://journals.ums.ac.id/index.php/bioeksperimen/article/view/23017anti-cancer, biomarkers, medicinal plant, metabolomic, review |
| spellingShingle | Yani Magfiroh Identification of Anti-Cancer Compounds in Medicinal Plants Using Metabolomic Approaches: A Review Bioeksperimen: Jurnal Penelitian Biologi anti-cancer, biomarkers, medicinal plant, metabolomic, review |
| title | Identification of Anti-Cancer Compounds in Medicinal Plants Using Metabolomic Approaches: A Review |
| title_full | Identification of Anti-Cancer Compounds in Medicinal Plants Using Metabolomic Approaches: A Review |
| title_fullStr | Identification of Anti-Cancer Compounds in Medicinal Plants Using Metabolomic Approaches: A Review |
| title_full_unstemmed | Identification of Anti-Cancer Compounds in Medicinal Plants Using Metabolomic Approaches: A Review |
| title_short | Identification of Anti-Cancer Compounds in Medicinal Plants Using Metabolomic Approaches: A Review |
| title_sort | identification of anti cancer compounds in medicinal plants using metabolomic approaches a review |
| topic | anti-cancer, biomarkers, medicinal plant, metabolomic, review |
| url | https://journals.ums.ac.id/index.php/bioeksperimen/article/view/23017 |
| work_keys_str_mv | AT yanimagfiroh identificationofanticancercompoundsinmedicinalplantsusingmetabolomicapproachesareview |