Prognostic factors of survival in treatment of scalp angiosarcoma in Chinese population
Background: Scalp angiosarcoma is a rare soft tissue sarcoma with a very poor prognosis and high mortality. Due to its low incidence, prognostic factors and treatment strategies are not well defined. Objective: This study aims to report our long-term results in terms of survival and prognostic facto...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-03-01
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| Series: | JPRAS Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352587815000558 |
| _version_ | 1819294407254343680 |
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| author | Sherby Suet Ying Pang George Kam Hop Li |
| author_facet | Sherby Suet Ying Pang George Kam Hop Li |
| author_sort | Sherby Suet Ying Pang |
| collection | DOAJ |
| description | Background: Scalp angiosarcoma is a rare soft tissue sarcoma with a very poor prognosis and high mortality. Due to its low incidence, prognostic factors and treatment strategies are not well defined.
Objective: This study aims to report our long-term results in terms of survival and prognostic factors affecting survival through retrospective analysis of 38 consecutive patients with scalp angiosarcoma who underwent treatment at two different plastic centers in Hong Kong.
Result: The overall survival rate for 1, 3, and 5 years of maximally treated patients was 56%, 24%, and 12%, respectively. Univariate analysis with Cox regression model showed that age >70 years (risk ratio, RR 5.0; p = 0.02), satellite lesion on presentation (RR 8.4, p = 0.02), and tumor of size >5 cm (RR 2.79, p = 0.05) were factors affecting the overall survival. Multivariate analysis showed that only the involved deep resection margin was a significant risk factor (RR 8.6, p = 0.02) However, univariate analysis showed that the involved deep resection margin (RR 10.2, p = 0.01) and satellite lesion on presentation (RR 0.73, p = 0.01) were factors affecting disease-free survival. Besides, satellite lesion on presentation predicted local recurrence on univariate analysis (RR 2, p = 0.01).
Conclusions: The prognosis in terms of overall survival and local disease control was poor with a 5-year survival rate of 12% in maximally treated patients. |
| first_indexed | 2024-12-24T04:25:50Z |
| format | Article |
| id | doaj.art-1c56b29a28804407a1098d178b2fd63f |
| institution | Directory Open Access Journal |
| issn | 2352-5878 |
| language | English |
| last_indexed | 2024-12-24T04:25:50Z |
| publishDate | 2016-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JPRAS Open |
| spelling | doaj.art-1c56b29a28804407a1098d178b2fd63f2022-12-21T17:15:36ZengElsevierJPRAS Open2352-58782016-03-017C1710.1016/j.jpra.2015.10.004Prognostic factors of survival in treatment of scalp angiosarcoma in Chinese populationSherby Suet Ying PangGeorge Kam Hop LiBackground: Scalp angiosarcoma is a rare soft tissue sarcoma with a very poor prognosis and high mortality. Due to its low incidence, prognostic factors and treatment strategies are not well defined. Objective: This study aims to report our long-term results in terms of survival and prognostic factors affecting survival through retrospective analysis of 38 consecutive patients with scalp angiosarcoma who underwent treatment at two different plastic centers in Hong Kong. Result: The overall survival rate for 1, 3, and 5 years of maximally treated patients was 56%, 24%, and 12%, respectively. Univariate analysis with Cox regression model showed that age >70 years (risk ratio, RR 5.0; p = 0.02), satellite lesion on presentation (RR 8.4, p = 0.02), and tumor of size >5 cm (RR 2.79, p = 0.05) were factors affecting the overall survival. Multivariate analysis showed that only the involved deep resection margin was a significant risk factor (RR 8.6, p = 0.02) However, univariate analysis showed that the involved deep resection margin (RR 10.2, p = 0.01) and satellite lesion on presentation (RR 0.73, p = 0.01) were factors affecting disease-free survival. Besides, satellite lesion on presentation predicted local recurrence on univariate analysis (RR 2, p = 0.01). Conclusions: The prognosis in terms of overall survival and local disease control was poor with a 5-year survival rate of 12% in maximally treated patients.http://www.sciencedirect.com/science/article/pii/S2352587815000558AngiosarcomaScalp angiosarcomaCutaneous angiosarcomaHemangiosarcoma |
| spellingShingle | Sherby Suet Ying Pang George Kam Hop Li Prognostic factors of survival in treatment of scalp angiosarcoma in Chinese population JPRAS Open Angiosarcoma Scalp angiosarcoma Cutaneous angiosarcoma Hemangiosarcoma |
| title | Prognostic factors of survival in treatment of scalp angiosarcoma in Chinese population |
| title_full | Prognostic factors of survival in treatment of scalp angiosarcoma in Chinese population |
| title_fullStr | Prognostic factors of survival in treatment of scalp angiosarcoma in Chinese population |
| title_full_unstemmed | Prognostic factors of survival in treatment of scalp angiosarcoma in Chinese population |
| title_short | Prognostic factors of survival in treatment of scalp angiosarcoma in Chinese population |
| title_sort | prognostic factors of survival in treatment of scalp angiosarcoma in chinese population |
| topic | Angiosarcoma Scalp angiosarcoma Cutaneous angiosarcoma Hemangiosarcoma |
| url | http://www.sciencedirect.com/science/article/pii/S2352587815000558 |
| work_keys_str_mv | AT sherbysuetyingpang prognosticfactorsofsurvivalintreatmentofscalpangiosarcomainchinesepopulation AT georgekamhopli prognosticfactorsofsurvivalintreatmentofscalpangiosarcomainchinesepopulation |