Revolutionizing anti-tumor therapy: unleashing the potential of B cell-derived exosomes
B cells occupy a vital role in the functioning of the immune system, working in tandem with T cells to either suppress or promote tumor growth within the tumor microenvironment(TME). In addition to direct cell-to-cell communication, B cells and other cells release exosomes, small membrane vesicles r...
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1188760/full |
| _version_ | 1797810972630450176 |
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| author | Jingwen Xiong Hao Chi Guanhu Yang Songyun Zhao Jing Zhang Lisa Jia Tran Zhijia Xia Fang Yang Gang Tian |
| author_facet | Jingwen Xiong Hao Chi Guanhu Yang Songyun Zhao Jing Zhang Lisa Jia Tran Zhijia Xia Fang Yang Gang Tian |
| author_sort | Jingwen Xiong |
| collection | DOAJ |
| description | B cells occupy a vital role in the functioning of the immune system, working in tandem with T cells to either suppress or promote tumor growth within the tumor microenvironment(TME). In addition to direct cell-to-cell communication, B cells and other cells release exosomes, small membrane vesicles ranging in size from 30-150 nm, that facilitate intercellular signaling. Exosome research is an important development in cancer research, as they have been shown to carry various molecules such as major histocompatibility complex(MHC) molecules and integrins, which regulate the TME. Given the close association between TME and cancer development, targeting substances within the TME has emerged as a promising strategy for cancer therapy. This review aims to present a comprehensive overview of the contributions made by B cells and exosomes to the tumor microenvironment (TME). Additionally, we delve into the potential role of B cell-derived exosomes in the progression of cancer. |
| first_indexed | 2024-03-13T07:16:45Z |
| format | Article |
| id | doaj.art-1c59c88d7a6c430b96ceb5b32c76665a |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-13T07:16:45Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-1c59c88d7a6c430b96ceb5b32c76665a2023-06-05T05:05:16ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-06-011410.3389/fimmu.2023.11887601188760Revolutionizing anti-tumor therapy: unleashing the potential of B cell-derived exosomesJingwen Xiong0Hao Chi1Guanhu Yang2Songyun Zhao3Jing Zhang4Lisa Jia Tran5Zhijia Xia6Fang Yang7Gang Tian8Department of Sports Rehabilitation, Southwest Medical University, Luzhou, ChinaClinical Medical College, Southwest Medical University, Luzhou, ChinaDepartment of Specialty Medicine, Ohio University, Athens, OH, United StatesDepartment of Neurosurgery, Wuxi People’s Hospital Affiliated to Nanjing Medical University, Wuxi, ChinaDivision of Basic Biomedical Sciences, The University of South Dakota Sanford School of Medicine, Vermillion, SD, United StatesDepartment of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, GermanyDepartment of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, GermanyDepartment of Ophthalmology, Charité – Universitätsmedizin Berlin, Berlin, GermanyDepartment of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaB cells occupy a vital role in the functioning of the immune system, working in tandem with T cells to either suppress or promote tumor growth within the tumor microenvironment(TME). In addition to direct cell-to-cell communication, B cells and other cells release exosomes, small membrane vesicles ranging in size from 30-150 nm, that facilitate intercellular signaling. Exosome research is an important development in cancer research, as they have been shown to carry various molecules such as major histocompatibility complex(MHC) molecules and integrins, which regulate the TME. Given the close association between TME and cancer development, targeting substances within the TME has emerged as a promising strategy for cancer therapy. This review aims to present a comprehensive overview of the contributions made by B cells and exosomes to the tumor microenvironment (TME). Additionally, we delve into the potential role of B cell-derived exosomes in the progression of cancer.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1188760/fullB cellB cell-derived exosometherapyTMEanti-tumor |
| spellingShingle | Jingwen Xiong Hao Chi Guanhu Yang Songyun Zhao Jing Zhang Lisa Jia Tran Zhijia Xia Fang Yang Gang Tian Revolutionizing anti-tumor therapy: unleashing the potential of B cell-derived exosomes Frontiers in Immunology B cell B cell-derived exosome therapy TME anti-tumor |
| title | Revolutionizing anti-tumor therapy: unleashing the potential of B cell-derived exosomes |
| title_full | Revolutionizing anti-tumor therapy: unleashing the potential of B cell-derived exosomes |
| title_fullStr | Revolutionizing anti-tumor therapy: unleashing the potential of B cell-derived exosomes |
| title_full_unstemmed | Revolutionizing anti-tumor therapy: unleashing the potential of B cell-derived exosomes |
| title_short | Revolutionizing anti-tumor therapy: unleashing the potential of B cell-derived exosomes |
| title_sort | revolutionizing anti tumor therapy unleashing the potential of b cell derived exosomes |
| topic | B cell B cell-derived exosome therapy TME anti-tumor |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1188760/full |
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