Interaction among dietary n‐3 and n‐6 polyunsaturated fatty acid intake, fatty acid desaturase 2 genetic variants, and low‐density lipoprotein cholesterol levels in type 2 diabetes patients
Abstract Aims/Introduction Fatty acid desaturase (FADS) genetic polymorphisms are strongly correlated with the risk of dyslipidemia and cardiovascular disease. In this study, we examined the impact of FADS1 and FADS2 genetic variants on plasma lipid status, and assessed interactions between FADS gen...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-02-01
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| Series: | Journal of Diabetes Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jdi.13944 |
| _version_ | 1797937945748963328 |
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| author | Pei‐Chi Huang Hsuan Cheng Yu‐Ting Su Meng‐Chuan Huang Chih‐Cheng Hsu Shang‐Jyh Hwang Shyi‐Jang Shin Wen‐Tsan Chang |
| author_facet | Pei‐Chi Huang Hsuan Cheng Yu‐Ting Su Meng‐Chuan Huang Chih‐Cheng Hsu Shang‐Jyh Hwang Shyi‐Jang Shin Wen‐Tsan Chang |
| author_sort | Pei‐Chi Huang |
| collection | DOAJ |
| description | Abstract Aims/Introduction Fatty acid desaturase (FADS) genetic polymorphisms are strongly correlated with the risk of dyslipidemia and cardiovascular disease. In this study, we examined the impact of FADS1 and FADS2 genetic variants on plasma lipid status, and assessed interactions between FADS genetic polymorphisms and plasma n‐3/n‐6 fatty acids regarding lipid status within a population of 816 Taiwanese patients with type 2 diabetes. Materials and Methods Selected tag single‐nucleotide polymorphisms (FADS1 rs174546 [T/C]; FADS2 rs174602 [A/G] and rs2072114 [A/G]) were genotyped (n = 816). Results The distribution of genotypes were compared with reports publicly available in the Genome Aggregation Database for East Asian populations (https://gnomad.broadinstitute.org). In the subgroup of patients not taking lipid‐lowering medications (n = 192), we observed that the G allele of FADS2 rs174602 was statistically significantly correlated with lower low‐density lipoprotein cholesterol (LDL‐C) concentrations (P = 0.001), whereas the G allele of rs2072114 was marginally associated with LDL‐C concentrations (P = 0.091). Using a general linear model adjusted for confounding factors, statistically significant interactions (P = 0.016) between single‐nucleotide polymorphisms in rs2072114 and a low alpha‐linolenic acid (18:3n‐3)/linoleic acid (18:2n‐6) ratio; the G allele correlated with lower LDL‐C levels among individuals with a low alpha‐linolenic acid/linoleic acid ratio. Interaction between rs174602 single‐nucleotide polymorphisms and low alpha‐linolenic acid/linoleic acid values on LDL‐C was only marginally significant (P = 0.063). Conclusions Our results show the role of n‐3/n‐6 dietary polyunsaturated fatty acids in modifying the effects of genetic susceptibility on lipoprotein concentrations in patients with type 2 diabetes. Our findings highlight the potential of interventions with dietary polyunsaturated fatty acids regarding developing individualized prevention strategies for type 2 diabetes presenting with co‐occurring dyslipidemia and cardiovascular diseases. |
| first_indexed | 2024-04-10T18:53:16Z |
| format | Article |
| id | doaj.art-1c5aa1cd80ab45a9a8ded8be325824d7 |
| institution | Directory Open Access Journal |
| issn | 2040-1116 2040-1124 |
| language | English |
| last_indexed | 2024-04-10T18:53:16Z |
| publishDate | 2023-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj.art-1c5aa1cd80ab45a9a8ded8be325824d72023-02-01T05:12:51ZengWileyJournal of Diabetes Investigation2040-11162040-11242023-02-0114229730810.1111/jdi.13944Interaction among dietary n‐3 and n‐6 polyunsaturated fatty acid intake, fatty acid desaturase 2 genetic variants, and low‐density lipoprotein cholesterol levels in type 2 diabetes patientsPei‐Chi Huang0Hsuan Cheng1Yu‐Ting Su2Meng‐Chuan Huang3Chih‐Cheng Hsu4Shang‐Jyh Hwang5Shyi‐Jang Shin6Wen‐Tsan Chang7Department of Public Health and Environmental Medicine, School of Medicine, College of Medicine Kaohsiung Medical University Kaohsiung TaiwanDepartment of Public Health and Environmental Medicine, School of Medicine, College of Medicine Kaohsiung Medical University Kaohsiung TaiwanDepartment of Public Health and Environmental Medicine, School of Medicine, College of Medicine Kaohsiung Medical University Kaohsiung TaiwanDepartment of Public Health and Environmental Medicine, School of Medicine, College of Medicine Kaohsiung Medical University Kaohsiung TaiwanInstitute of Population Health Sciences National Health Research Institutes Zhunan TaiwanDepartment of Internal Medicine Kaohsiung Medical University Hospital, Kaohsiung Medical University Kaohsiung TaiwanDepartment of Internal Medicine Kaohsiung Medical University Hospital, Kaohsiung Medical University Kaohsiung TaiwanDivision of General and Digestive Surgery, Department of Surgery Kaohsiung Medical University Hospital Kaohsiung TaiwanAbstract Aims/Introduction Fatty acid desaturase (FADS) genetic polymorphisms are strongly correlated with the risk of dyslipidemia and cardiovascular disease. In this study, we examined the impact of FADS1 and FADS2 genetic variants on plasma lipid status, and assessed interactions between FADS genetic polymorphisms and plasma n‐3/n‐6 fatty acids regarding lipid status within a population of 816 Taiwanese patients with type 2 diabetes. Materials and Methods Selected tag single‐nucleotide polymorphisms (FADS1 rs174546 [T/C]; FADS2 rs174602 [A/G] and rs2072114 [A/G]) were genotyped (n = 816). Results The distribution of genotypes were compared with reports publicly available in the Genome Aggregation Database for East Asian populations (https://gnomad.broadinstitute.org). In the subgroup of patients not taking lipid‐lowering medications (n = 192), we observed that the G allele of FADS2 rs174602 was statistically significantly correlated with lower low‐density lipoprotein cholesterol (LDL‐C) concentrations (P = 0.001), whereas the G allele of rs2072114 was marginally associated with LDL‐C concentrations (P = 0.091). Using a general linear model adjusted for confounding factors, statistically significant interactions (P = 0.016) between single‐nucleotide polymorphisms in rs2072114 and a low alpha‐linolenic acid (18:3n‐3)/linoleic acid (18:2n‐6) ratio; the G allele correlated with lower LDL‐C levels among individuals with a low alpha‐linolenic acid/linoleic acid ratio. Interaction between rs174602 single‐nucleotide polymorphisms and low alpha‐linolenic acid/linoleic acid values on LDL‐C was only marginally significant (P = 0.063). Conclusions Our results show the role of n‐3/n‐6 dietary polyunsaturated fatty acids in modifying the effects of genetic susceptibility on lipoprotein concentrations in patients with type 2 diabetes. Our findings highlight the potential of interventions with dietary polyunsaturated fatty acids regarding developing individualized prevention strategies for type 2 diabetes presenting with co‐occurring dyslipidemia and cardiovascular diseases.https://doi.org/10.1111/jdi.13944DiabetesFADS1FADS2 |
| spellingShingle | Pei‐Chi Huang Hsuan Cheng Yu‐Ting Su Meng‐Chuan Huang Chih‐Cheng Hsu Shang‐Jyh Hwang Shyi‐Jang Shin Wen‐Tsan Chang Interaction among dietary n‐3 and n‐6 polyunsaturated fatty acid intake, fatty acid desaturase 2 genetic variants, and low‐density lipoprotein cholesterol levels in type 2 diabetes patients Journal of Diabetes Investigation Diabetes FADS1 FADS2 |
| title | Interaction among dietary n‐3 and n‐6 polyunsaturated fatty acid intake, fatty acid desaturase 2 genetic variants, and low‐density lipoprotein cholesterol levels in type 2 diabetes patients |
| title_full | Interaction among dietary n‐3 and n‐6 polyunsaturated fatty acid intake, fatty acid desaturase 2 genetic variants, and low‐density lipoprotein cholesterol levels in type 2 diabetes patients |
| title_fullStr | Interaction among dietary n‐3 and n‐6 polyunsaturated fatty acid intake, fatty acid desaturase 2 genetic variants, and low‐density lipoprotein cholesterol levels in type 2 diabetes patients |
| title_full_unstemmed | Interaction among dietary n‐3 and n‐6 polyunsaturated fatty acid intake, fatty acid desaturase 2 genetic variants, and low‐density lipoprotein cholesterol levels in type 2 diabetes patients |
| title_short | Interaction among dietary n‐3 and n‐6 polyunsaturated fatty acid intake, fatty acid desaturase 2 genetic variants, and low‐density lipoprotein cholesterol levels in type 2 diabetes patients |
| title_sort | interaction among dietary n 3 and n 6 polyunsaturated fatty acid intake fatty acid desaturase 2 genetic variants and low density lipoprotein cholesterol levels in type 2 diabetes patients |
| topic | Diabetes FADS1 FADS2 |
| url | https://doi.org/10.1111/jdi.13944 |
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