Percutaneous Two-Dimensional Shear Wave Elastography for Diagnosis of Pancreatic Tumor
Background: To investigate the efficacy of two-dimensional shear wave elastography (2D-SWE) for the diagnosis of pancreatic mass lesions. Methods: This ethics committee–approved cross-sectional study included 52 patients with histologically-proven pancreatic tumors (pancreatic ductal adenocarcinoma...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/3/498 |
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| author | Yotaro Iino Hitoshi Maruyama Rintaro Mikata Shin Yasui Keisuke Koroki Hiroki Nagashima Masami Awatsu Ayako Shingyoji Yuko Kusakabe Kazufumi Kobayashi Soichiro Kiyono Masato Nakamura Hiroshi Ohyama Harutoshi Sugiyama Yuji Sakai Tetsuhiro Chiba Jun Kato Toshio Tsuyuguchi Naoya Kato |
| author_facet | Yotaro Iino Hitoshi Maruyama Rintaro Mikata Shin Yasui Keisuke Koroki Hiroki Nagashima Masami Awatsu Ayako Shingyoji Yuko Kusakabe Kazufumi Kobayashi Soichiro Kiyono Masato Nakamura Hiroshi Ohyama Harutoshi Sugiyama Yuji Sakai Tetsuhiro Chiba Jun Kato Toshio Tsuyuguchi Naoya Kato |
| author_sort | Yotaro Iino |
| collection | DOAJ |
| description | Background: To investigate the efficacy of two-dimensional shear wave elastography (2D-SWE) for the diagnosis of pancreatic mass lesions. Methods: This ethics committee–approved cross-sectional study included 52 patients with histologically-proven pancreatic tumors (pancreatic ductal adenocarcinoma (PDAC), 36; tumor-forming pancreatitis (TFP), 15; neuroendocrine tumor, 1) and 33 control subjects. The 2D-SWE was performed for the tumor/non-tumor tissues, and SWE-mapping patterns and propagation quality were assessed. Results: Three mapping patterns were detected based on the size and distribution of the coloring areas. Pattern A (whole coloring) was detected in all non-tumor tissues and TFP, whereas pattern C (multiple small coloring spots) was detected in PDAC only. Pattern B (partial coloring with smaller spots) was detected in other lesions. The specificity and positive predictive value of pattern A for non-PDAC and those of pattern C for PDAC were 100%. The SWE value was higher in tumor lesions than in the non-tumor tissues (38.1 vs. 9.8 kPa; <i>p</i> < 0.001) in patients with PDAC. The SWE value in the non-tumor lesion was higher in patients with PDAC than in control (9.8 vs. 7.5 kPa; <i>p</i> < 0.001). Conclusions: 2D-SWE may play a role as a novel diagnostic tool for PDAC to detect a specific mapping pattern with quantitative assessment. |
| first_indexed | 2024-03-10T13:20:02Z |
| format | Article |
| id | doaj.art-1c5e546e78c04d85b60af41aad2aa6c2 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T13:20:02Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-1c5e546e78c04d85b60af41aad2aa6c22023-11-21T10:06:20ZengMDPI AGDiagnostics2075-44182021-03-0111349810.3390/diagnostics11030498Percutaneous Two-Dimensional Shear Wave Elastography for Diagnosis of Pancreatic TumorYotaro Iino0Hitoshi Maruyama1Rintaro Mikata2Shin Yasui3Keisuke Koroki4Hiroki Nagashima5Masami Awatsu6Ayako Shingyoji7Yuko Kusakabe8Kazufumi Kobayashi9Soichiro Kiyono10Masato Nakamura11Hiroshi Ohyama12Harutoshi Sugiyama13Yuji Sakai14Tetsuhiro Chiba15Jun Kato16Toshio Tsuyuguchi17Naoya Kato18Department of Gastroenterology, Chiba University Graduate School of Medicine, 1-8-1 Inohan, Chuo-ku Chiba City 260-8670, JapanDepartment of Gastroenterology, Chiba University Graduate School of Medicine, 1-8-1 Inohan, Chuo-ku Chiba City 260-8670, JapanDepartment of Gastroenterology, Chiba University Graduate School of Medicine, 1-8-1 Inohan, Chuo-ku Chiba City 260-8670, JapanDepartment of Gastroenterology, Chiba University Graduate School of Medicine, 1-8-1 Inohan, Chuo-ku Chiba City 260-8670, JapanDepartment of Gastroenterology, Chiba University Graduate School of Medicine, 1-8-1 Inohan, Chuo-ku Chiba City 260-8670, JapanDepartment of Gastroenterology, Chiba University Graduate School of Medicine, 1-8-1 Inohan, Chuo-ku Chiba City 260-8670, JapanDepartment of Gastroenterology, Chiba University Graduate School of Medicine, 1-8-1 Inohan, Chuo-ku Chiba City 260-8670, JapanDepartment of Gastroenterology, Chiba University Graduate School of Medicine, 1-8-1 Inohan, Chuo-ku Chiba City 260-8670, JapanDepartment of Gastroenterology, Chiba University Graduate School of Medicine, 1-8-1 Inohan, Chuo-ku Chiba City 260-8670, JapanDepartment of Gastroenterology, Chiba University Graduate School of Medicine, 1-8-1 Inohan, Chuo-ku Chiba City 260-8670, JapanDepartment of Gastroenterology, Chiba University Graduate School of Medicine, 1-8-1 Inohan, Chuo-ku Chiba City 260-8670, JapanDepartment of Gastroenterology, Chiba University Graduate School of Medicine, 1-8-1 Inohan, Chuo-ku Chiba City 260-8670, JapanDepartment of Gastroenterology, Chiba University Graduate School of Medicine, 1-8-1 Inohan, Chuo-ku Chiba City 260-8670, JapanDepartment of Gastroenterology, Chiba University Graduate School of Medicine, 1-8-1 Inohan, Chuo-ku Chiba City 260-8670, JapanDepartment of Gastroenterology, Chiba University Graduate School of Medicine, 1-8-1 Inohan, Chuo-ku Chiba City 260-8670, JapanDepartment of Gastroenterology, Chiba University Graduate School of Medicine, 1-8-1 Inohan, Chuo-ku Chiba City 260-8670, JapanDepartment of Gastroenterology, Chiba University Graduate School of Medicine, 1-8-1 Inohan, Chuo-ku Chiba City 260-8670, JapanDepartment of Gastroenterology, Chiba University Graduate School of Medicine, 1-8-1 Inohan, Chuo-ku Chiba City 260-8670, JapanDepartment of Gastroenterology, Chiba University Graduate School of Medicine, 1-8-1 Inohan, Chuo-ku Chiba City 260-8670, JapanBackground: To investigate the efficacy of two-dimensional shear wave elastography (2D-SWE) for the diagnosis of pancreatic mass lesions. Methods: This ethics committee–approved cross-sectional study included 52 patients with histologically-proven pancreatic tumors (pancreatic ductal adenocarcinoma (PDAC), 36; tumor-forming pancreatitis (TFP), 15; neuroendocrine tumor, 1) and 33 control subjects. The 2D-SWE was performed for the tumor/non-tumor tissues, and SWE-mapping patterns and propagation quality were assessed. Results: Three mapping patterns were detected based on the size and distribution of the coloring areas. Pattern A (whole coloring) was detected in all non-tumor tissues and TFP, whereas pattern C (multiple small coloring spots) was detected in PDAC only. Pattern B (partial coloring with smaller spots) was detected in other lesions. The specificity and positive predictive value of pattern A for non-PDAC and those of pattern C for PDAC were 100%. The SWE value was higher in tumor lesions than in the non-tumor tissues (38.1 vs. 9.8 kPa; <i>p</i> < 0.001) in patients with PDAC. The SWE value in the non-tumor lesion was higher in patients with PDAC than in control (9.8 vs. 7.5 kPa; <i>p</i> < 0.001). Conclusions: 2D-SWE may play a role as a novel diagnostic tool for PDAC to detect a specific mapping pattern with quantitative assessment.https://www.mdpi.com/2075-4418/11/3/498pancreatic cancer2D-shear wave elastographyultrasonographytumor-forming pancreatitis |
| spellingShingle | Yotaro Iino Hitoshi Maruyama Rintaro Mikata Shin Yasui Keisuke Koroki Hiroki Nagashima Masami Awatsu Ayako Shingyoji Yuko Kusakabe Kazufumi Kobayashi Soichiro Kiyono Masato Nakamura Hiroshi Ohyama Harutoshi Sugiyama Yuji Sakai Tetsuhiro Chiba Jun Kato Toshio Tsuyuguchi Naoya Kato Percutaneous Two-Dimensional Shear Wave Elastography for Diagnosis of Pancreatic Tumor Diagnostics pancreatic cancer 2D-shear wave elastography ultrasonography tumor-forming pancreatitis |
| title | Percutaneous Two-Dimensional Shear Wave Elastography for Diagnosis of Pancreatic Tumor |
| title_full | Percutaneous Two-Dimensional Shear Wave Elastography for Diagnosis of Pancreatic Tumor |
| title_fullStr | Percutaneous Two-Dimensional Shear Wave Elastography for Diagnosis of Pancreatic Tumor |
| title_full_unstemmed | Percutaneous Two-Dimensional Shear Wave Elastography for Diagnosis of Pancreatic Tumor |
| title_short | Percutaneous Two-Dimensional Shear Wave Elastography for Diagnosis of Pancreatic Tumor |
| title_sort | percutaneous two dimensional shear wave elastography for diagnosis of pancreatic tumor |
| topic | pancreatic cancer 2D-shear wave elastography ultrasonography tumor-forming pancreatitis |
| url | https://www.mdpi.com/2075-4418/11/3/498 |
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