Inhibin secretion in women with the polycystic ovary syndrome before and after treatment with progesterone
<p>Abstract</p> <p>Objectives</p> <p>It has been suggested that inhibin secretion is altered in women with the polycystic ovary syndrome (PCOS). However, the contribution of a preceding luteal phase has not been taken into account. The aim of the present study was to in...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-04-01
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| Series: | Reproductive Biology and Endocrinology |
| Online Access: | http://www.rbej.com/content/9/1/59 |
| _version_ | 1818385927995654144 |
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| author | Anifandis George Pournaras Spyros Messini Christina I Venetis Christos Dafopoulos Konstantinos Garas Antonios Messinis Ioannis E |
| author_facet | Anifandis George Pournaras Spyros Messini Christina I Venetis Christos Dafopoulos Konstantinos Garas Antonios Messinis Ioannis E |
| author_sort | Anifandis George |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Objectives</p> <p>It has been suggested that inhibin secretion is altered in women with the polycystic ovary syndrome (PCOS). However, the contribution of a preceding luteal phase has not been taken into account. The aim of the present study was to investigate whether progesterone in the context of a simulated luteal phase affects basal and FSH-induced inhibin secretion in women with PCOS and elevated LH.</p> <p>Methods</p> <p>Ten women with PCOS and 8 normally cycling women participated in an experimental procedure (Exp) involving the administration of a single injection of recombinant FSH (450 IU sc). In the women with PCOS, the procedure was performed before (Exp 1) and after a 20-day treatment with progesterone (Exp 2), while in the normal women on day 2 of the cycle (Exp 3). Inhibin A and B levels were measured in blood samples taken before and 24 hours after the FSH injection.</p> <p>Results</p> <p>Basal LH levels were significantly higher and inhibin A levels were significantly lower in the PCOS group compared to the control group, while inhibin B levels were comparable in the two groups. In the PCOS group, after treatment with progesterone inhibin A and LH but not inhibin B levels decreased significantly (p < 0.05). After the FSH injection, inhibin A and B levels increased significantly in the women with PCOS (Exp 1 and Exp 2) but not in the control women (Exp 3).</p> <p>Conclusions</p> <p>In women with PCOS, as compared to control women, the dissimilar pattern of inhibin A and inhibin B secretion in response to FSH appears to be independent of a preceding simulated luteal phase. It is possible that compared to normal ovaries, the PCOS ovaries are less sensitive to endogenous LH regarding inhibin A secretion and more sensitive to exogenous FSH stimulation in terms of inhibin A and inhibin B secretion.</p> |
| first_indexed | 2024-12-14T03:45:56Z |
| format | Article |
| id | doaj.art-1c5efcef0a8a4ebd904c8a7a4d313861 |
| institution | Directory Open Access Journal |
| issn | 1477-7827 |
| language | English |
| last_indexed | 2024-12-14T03:45:56Z |
| publishDate | 2011-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj.art-1c5efcef0a8a4ebd904c8a7a4d3138612022-12-21T23:18:21ZengBMCReproductive Biology and Endocrinology1477-78272011-04-01915910.1186/1477-7827-9-59Inhibin secretion in women with the polycystic ovary syndrome before and after treatment with progesteroneAnifandis GeorgePournaras SpyrosMessini Christina IVenetis ChristosDafopoulos KonstantinosGaras AntoniosMessinis Ioannis E<p>Abstract</p> <p>Objectives</p> <p>It has been suggested that inhibin secretion is altered in women with the polycystic ovary syndrome (PCOS). However, the contribution of a preceding luteal phase has not been taken into account. The aim of the present study was to investigate whether progesterone in the context of a simulated luteal phase affects basal and FSH-induced inhibin secretion in women with PCOS and elevated LH.</p> <p>Methods</p> <p>Ten women with PCOS and 8 normally cycling women participated in an experimental procedure (Exp) involving the administration of a single injection of recombinant FSH (450 IU sc). In the women with PCOS, the procedure was performed before (Exp 1) and after a 20-day treatment with progesterone (Exp 2), while in the normal women on day 2 of the cycle (Exp 3). Inhibin A and B levels were measured in blood samples taken before and 24 hours after the FSH injection.</p> <p>Results</p> <p>Basal LH levels were significantly higher and inhibin A levels were significantly lower in the PCOS group compared to the control group, while inhibin B levels were comparable in the two groups. In the PCOS group, after treatment with progesterone inhibin A and LH but not inhibin B levels decreased significantly (p < 0.05). After the FSH injection, inhibin A and B levels increased significantly in the women with PCOS (Exp 1 and Exp 2) but not in the control women (Exp 3).</p> <p>Conclusions</p> <p>In women with PCOS, as compared to control women, the dissimilar pattern of inhibin A and inhibin B secretion in response to FSH appears to be independent of a preceding simulated luteal phase. It is possible that compared to normal ovaries, the PCOS ovaries are less sensitive to endogenous LH regarding inhibin A secretion and more sensitive to exogenous FSH stimulation in terms of inhibin A and inhibin B secretion.</p>http://www.rbej.com/content/9/1/59 |
| spellingShingle | Anifandis George Pournaras Spyros Messini Christina I Venetis Christos Dafopoulos Konstantinos Garas Antonios Messinis Ioannis E Inhibin secretion in women with the polycystic ovary syndrome before and after treatment with progesterone Reproductive Biology and Endocrinology |
| title | Inhibin secretion in women with the polycystic ovary syndrome before and after treatment with progesterone |
| title_full | Inhibin secretion in women with the polycystic ovary syndrome before and after treatment with progesterone |
| title_fullStr | Inhibin secretion in women with the polycystic ovary syndrome before and after treatment with progesterone |
| title_full_unstemmed | Inhibin secretion in women with the polycystic ovary syndrome before and after treatment with progesterone |
| title_short | Inhibin secretion in women with the polycystic ovary syndrome before and after treatment with progesterone |
| title_sort | inhibin secretion in women with the polycystic ovary syndrome before and after treatment with progesterone |
| url | http://www.rbej.com/content/9/1/59 |
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