SIRT1 Activation Using CRISPR/dCas9 Promotes Regeneration of Human Corneal Endothelial Cells through Inhibiting Senescence

SIRT1 Activation Using CRISPR/dCas9 Promotes Regeneration of Human Corneal Endothelial Cells through Inhibiting Senescence

Human corneal endothelial cells (hCECs) are restricted in proliferative capacity in vivo. Reduction in the number of hCEC leads to persistent corneal edema requiring corneal transplantation. This study demonstrates the functions of SIRT1 in hCECs and its potential for corneal endothelial regeneratio...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Hye Jun Joo, Dae Joong Ma, Jin Sun Hwang, Young Joo Shin
Fformat:	Erthygl
Iaith:	English
Cyhoeddwyd:	MDPI AG 2020-11-01
Cyfres:	Antioxidants
Pynciau:	SIRT1 corneal endothelial cells senescence CRISPR/dCas9
Mynediad Ar-lein:	https://www.mdpi.com/2076-3921/9/11/1085

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