SIRT1 Activation Using CRISPR/dCas9 Promotes Regeneration of Human Corneal Endothelial Cells through Inhibiting Senescence
Human corneal endothelial cells (hCECs) are restricted in proliferative capacity in vivo. Reduction in the number of hCEC leads to persistent corneal edema requiring corneal transplantation. This study demonstrates the functions of SIRT1 in hCECs and its potential for corneal endothelial regeneratio...
| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado: |
MDPI AG
2020-11-01
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| Series: | Antioxidants |
| Subjects: | |
| Acceso en liña: | https://www.mdpi.com/2076-3921/9/11/1085 |