Ferroptosis landscape in prostate cancer from molecular and metabolic perspective
Abstract Prostate cancer is a major disease that threatens men’s health. Its rapid progression, easy metastasis, and late castration resistance have brought obstacles to treatment. It is necessary to find new effective anticancer methods. Ferroptosis is a novel iron-dependent programmed cell death t...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-04-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-023-01430-0 |
| _version_ | 1797846063987556352 |
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| author | Jiaming Liang Yihao Liao Pu Wang Kun Yang Youzhi Wang Keke Wang Boqiang Zhong Diansheng Zhou Qian Cao Junbo Li Yang Zhao Ning Jiang |
| author_facet | Jiaming Liang Yihao Liao Pu Wang Kun Yang Youzhi Wang Keke Wang Boqiang Zhong Diansheng Zhou Qian Cao Junbo Li Yang Zhao Ning Jiang |
| author_sort | Jiaming Liang |
| collection | DOAJ |
| description | Abstract Prostate cancer is a major disease that threatens men’s health. Its rapid progression, easy metastasis, and late castration resistance have brought obstacles to treatment. It is necessary to find new effective anticancer methods. Ferroptosis is a novel iron-dependent programmed cell death that plays a role in various cancers. Understanding how ferroptosis is regulated in prostate cancer will help us to use it as a new way to kill cancer cells. In this review, we summarize the regulation and role of ferroptosis in prostate cancer and the relationship with AR from the perspective of metabolism and molecular pathways. We also discuss the feasibility of ferroptosis in prostate cancer treatment and describe current limitations and prospects, providing a reference for future research and clinical application of ferroptosis. |
| first_indexed | 2024-04-09T17:48:57Z |
| format | Article |
| id | doaj.art-1c6083db6c324939933aef2483554d6e |
| institution | Directory Open Access Journal |
| issn | 2058-7716 |
| language | English |
| last_indexed | 2024-04-09T17:48:57Z |
| publishDate | 2023-04-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj.art-1c6083db6c324939933aef2483554d6e2023-04-16T11:07:01ZengNature Publishing GroupCell Death Discovery2058-77162023-04-019111210.1038/s41420-023-01430-0Ferroptosis landscape in prostate cancer from molecular and metabolic perspectiveJiaming Liang0Yihao Liao1Pu Wang2Kun Yang3Youzhi Wang4Keke Wang5Boqiang Zhong6Diansheng Zhou7Qian Cao8Junbo Li9Yang Zhao10Ning Jiang11Tianjin institute of Urology, The Second Hospital of Tianjin Medical UniversityTianjin institute of Urology, The Second Hospital of Tianjin Medical UniversityTianjin institute of Urology, The Second Hospital of Tianjin Medical UniversitySchool of Future Technology, Xi’an Jiaotong UniversityTianjin institute of Urology, The Second Hospital of Tianjin Medical UniversityDepartment of Urology, Tangdu Hospital, The Air Force Military Medical UniversityTianjin institute of Urology, The Second Hospital of Tianjin Medical UniversityTianjin institute of Urology, The Second Hospital of Tianjin Medical UniversityTianjin institute of Urology, The Second Hospital of Tianjin Medical UniversityTianjin institute of Urology, The Second Hospital of Tianjin Medical UniversityDepartment of Radiology, Tianjin Medical University Second HospitalTianjin institute of Urology, The Second Hospital of Tianjin Medical UniversityAbstract Prostate cancer is a major disease that threatens men’s health. Its rapid progression, easy metastasis, and late castration resistance have brought obstacles to treatment. It is necessary to find new effective anticancer methods. Ferroptosis is a novel iron-dependent programmed cell death that plays a role in various cancers. Understanding how ferroptosis is regulated in prostate cancer will help us to use it as a new way to kill cancer cells. In this review, we summarize the regulation and role of ferroptosis in prostate cancer and the relationship with AR from the perspective of metabolism and molecular pathways. We also discuss the feasibility of ferroptosis in prostate cancer treatment and describe current limitations and prospects, providing a reference for future research and clinical application of ferroptosis.https://doi.org/10.1038/s41420-023-01430-0 |
| spellingShingle | Jiaming Liang Yihao Liao Pu Wang Kun Yang Youzhi Wang Keke Wang Boqiang Zhong Diansheng Zhou Qian Cao Junbo Li Yang Zhao Ning Jiang Ferroptosis landscape in prostate cancer from molecular and metabolic perspective Cell Death Discovery |
| title | Ferroptosis landscape in prostate cancer from molecular and metabolic perspective |
| title_full | Ferroptosis landscape in prostate cancer from molecular and metabolic perspective |
| title_fullStr | Ferroptosis landscape in prostate cancer from molecular and metabolic perspective |
| title_full_unstemmed | Ferroptosis landscape in prostate cancer from molecular and metabolic perspective |
| title_short | Ferroptosis landscape in prostate cancer from molecular and metabolic perspective |
| title_sort | ferroptosis landscape in prostate cancer from molecular and metabolic perspective |
| url | https://doi.org/10.1038/s41420-023-01430-0 |
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