LIM Kinases in Osteosarcoma Development
Tumorigenesis is a long-term and multistage process that often leads to the formation of metastases. During this pathological course, two major events appear to be crucial: primary tumour growth and metastatic expansion. In this context, despite research and clinical advances during the past decades...
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MDPI AG
2021-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/12/3542 |
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| author | Régis Brion Laura Regnier Mathilde Mullard Jérome Amiaud Françoise Rédini Franck Verrecchia |
| author_facet | Régis Brion Laura Regnier Mathilde Mullard Jérome Amiaud Françoise Rédini Franck Verrecchia |
| author_sort | Régis Brion |
| collection | DOAJ |
| description | Tumorigenesis is a long-term and multistage process that often leads to the formation of metastases. During this pathological course, two major events appear to be crucial: primary tumour growth and metastatic expansion. In this context, despite research and clinical advances during the past decades, bone cancers remain a leading cause of death worldwide among paediatric cancer patients. Osteosarcomas are the most common malignant bone tumours in children and adolescents. Notwithstanding advances in therapeutic treatments, many patients succumb to these diseases. In particular, less than 30% of patients who demonstrate metastases at diagnosis or are poor responders to chemotherapy survive 5 years after initial diagnosis. LIM kinases (LIMKs), comprising LIMK1 and LIMK2, are common downstream effectors of several signalization pathways, and function as a signalling node that controls cytoskeleton dynamics through the phosphorylation of the cofilin family proteins. In recent decades, several reports have indicated that the functions of LIMKs are mainly implicated in the regulation of actin microfilament and the control of microtubule dynamics. Previous studies have thus identified LIMKs as cancer-promoting regulators in multiple organ cancers, such as breast cancer or prostate cancer. This review updates the current understanding of LIMK involvement in osteosarcoma progression. |
| first_indexed | 2024-03-10T04:25:29Z |
| format | Article |
| id | doaj.art-1c61661d1cca42bface97953110f855c |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T04:25:29Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-1c61661d1cca42bface97953110f855c2023-11-23T07:39:14ZengMDPI AGCells2073-44092021-12-011012354210.3390/cells10123542LIM Kinases in Osteosarcoma DevelopmentRégis Brion0Laura Regnier1Mathilde Mullard2Jérome Amiaud3Françoise Rédini4Franck Verrecchia5INSERM UMR1238, PHY-OS, Bone Sarcomas and Remodeling of Calcified Tissues, Nantes University, 44000 Nantes, FranceINSERM UMR1238, PHY-OS, Bone Sarcomas and Remodeling of Calcified Tissues, Nantes University, 44000 Nantes, FranceINSERM UMR1238, PHY-OS, Bone Sarcomas and Remodeling of Calcified Tissues, Nantes University, 44000 Nantes, FranceINSERM UMR1238, PHY-OS, Bone Sarcomas and Remodeling of Calcified Tissues, Nantes University, 44000 Nantes, FranceINSERM UMR1238, PHY-OS, Bone Sarcomas and Remodeling of Calcified Tissues, Nantes University, 44000 Nantes, FranceINSERM UMR1238, PHY-OS, Bone Sarcomas and Remodeling of Calcified Tissues, Nantes University, 44000 Nantes, FranceTumorigenesis is a long-term and multistage process that often leads to the formation of metastases. During this pathological course, two major events appear to be crucial: primary tumour growth and metastatic expansion. In this context, despite research and clinical advances during the past decades, bone cancers remain a leading cause of death worldwide among paediatric cancer patients. Osteosarcomas are the most common malignant bone tumours in children and adolescents. Notwithstanding advances in therapeutic treatments, many patients succumb to these diseases. In particular, less than 30% of patients who demonstrate metastases at diagnosis or are poor responders to chemotherapy survive 5 years after initial diagnosis. LIM kinases (LIMKs), comprising LIMK1 and LIMK2, are common downstream effectors of several signalization pathways, and function as a signalling node that controls cytoskeleton dynamics through the phosphorylation of the cofilin family proteins. In recent decades, several reports have indicated that the functions of LIMKs are mainly implicated in the regulation of actin microfilament and the control of microtubule dynamics. Previous studies have thus identified LIMKs as cancer-promoting regulators in multiple organ cancers, such as breast cancer or prostate cancer. This review updates the current understanding of LIMK involvement in osteosarcoma progression.https://www.mdpi.com/2073-4409/10/12/3542LIMKosteosarcomatherapeutic target |
| spellingShingle | Régis Brion Laura Regnier Mathilde Mullard Jérome Amiaud Françoise Rédini Franck Verrecchia LIM Kinases in Osteosarcoma Development Cells LIMK osteosarcoma therapeutic target |
| title | LIM Kinases in Osteosarcoma Development |
| title_full | LIM Kinases in Osteosarcoma Development |
| title_fullStr | LIM Kinases in Osteosarcoma Development |
| title_full_unstemmed | LIM Kinases in Osteosarcoma Development |
| title_short | LIM Kinases in Osteosarcoma Development |
| title_sort | lim kinases in osteosarcoma development |
| topic | LIMK osteosarcoma therapeutic target |
| url | https://www.mdpi.com/2073-4409/10/12/3542 |
| work_keys_str_mv | AT regisbrion limkinasesinosteosarcomadevelopment AT lauraregnier limkinasesinosteosarcomadevelopment AT mathildemullard limkinasesinosteosarcomadevelopment AT jeromeamiaud limkinasesinosteosarcomadevelopment AT francoiseredini limkinasesinosteosarcomadevelopment AT franckverrecchia limkinasesinosteosarcomadevelopment |