Signet ring cell carcinoma of the colon in a 10 year-old boy
Signet ring cell carcinoma (SRCC), a variant of adenocarcinoma, is defined by the presence of more than 50% of tumor cells with prominent intracytoplasmic mucin.1 Primary gastrointestinal malignancies constitute only 1% of pediatric neoplasms and 0.34% take the form of colon carcinoma. It is a very...
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| Format: | Article |
| Language: | English |
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Indonesian Pediatric Society Publishing House
2011-04-01
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| Series: | Paediatrica Indonesiana |
| Subjects: | |
| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/898 |
| _version_ | 1818008912571400192 |
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| author | Irene Irene Ketut Ariawati |
| author_facet | Irene Irene Ketut Ariawati |
| author_sort | Irene Irene |
| collection | DOAJ |
| description | Signet ring cell carcinoma (SRCC), a variant of adenocarcinoma, is defined by the presence of more than 50% of tumor cells with prominent intracytoplasmic mucin.1 Primary gastrointestinal malignancies constitute only 1% of pediatric neoplasms and 0.34% take the form of colon carcinoma. It is a very rare disease in persons under 17 years of age, 94% of which is found in children> 9 years of age. [.4 In contrast to adults, approximately
50% of colon carcinoma cases in children are the highly malignant mucin'producing adenocarcinoma type.4 The typical signet-ring cell has a large mucin vacuole that fills the cytoplasm and pushes the nuclei to the side, thereby giving the cells their signature histologic appearance.S,6 Carcinoma of the colon during childhood has been associated with familial
polyposis and ulcerative colitis. However, carcinoma arising de novo is the most common type.2,3 Risk factors include a high caloric diet rich in animal fat, sedentary lifestyle, smoking, alcohol consumption, low vegetable fibre consumption, chronic inflammatory bowel disease, ulcerative colitis, Crohn's disease, and polymorphism in key enzymes of injurious compounds.s |
| first_indexed | 2024-04-14T05:36:18Z |
| format | Article |
| id | doaj.art-1c620dad10834d9fa813b34c67a3fc3d |
| institution | Directory Open Access Journal |
| issn | 0030-9311 2338-476X |
| language | English |
| last_indexed | 2024-04-14T05:36:18Z |
| publishDate | 2011-04-01 |
| publisher | Indonesian Pediatric Society Publishing House |
| record_format | Article |
| series | Paediatrica Indonesiana |
| spelling | doaj.art-1c620dad10834d9fa813b34c67a3fc3d2022-12-22T02:09:38ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2011-04-015121162210.14238/pi51.2.2011.116-22758Signet ring cell carcinoma of the colon in a 10 year-old boyIrene Irene0Ketut Ariawati1Department of Child Health, Udayana University Medical School/Sanglah Hospital, Denpasar, BaliDepartment of Child Health, Udayana University Medical School/Sanglah Hospital, Denpasar, BaliSignet ring cell carcinoma (SRCC), a variant of adenocarcinoma, is defined by the presence of more than 50% of tumor cells with prominent intracytoplasmic mucin.1 Primary gastrointestinal malignancies constitute only 1% of pediatric neoplasms and 0.34% take the form of colon carcinoma. It is a very rare disease in persons under 17 years of age, 94% of which is found in children> 9 years of age. [.4 In contrast to adults, approximately 50% of colon carcinoma cases in children are the highly malignant mucin'producing adenocarcinoma type.4 The typical signet-ring cell has a large mucin vacuole that fills the cytoplasm and pushes the nuclei to the side, thereby giving the cells their signature histologic appearance.S,6 Carcinoma of the colon during childhood has been associated with familial polyposis and ulcerative colitis. However, carcinoma arising de novo is the most common type.2,3 Risk factors include a high caloric diet rich in animal fat, sedentary lifestyle, smoking, alcohol consumption, low vegetable fibre consumption, chronic inflammatory bowel disease, ulcerative colitis, Crohn's disease, and polymorphism in key enzymes of injurious compounds.shttps://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/898signet ring cell carcinomaSRCCcolonfamilial polyposisulcerative colitis |
| spellingShingle | Irene Irene Ketut Ariawati Signet ring cell carcinoma of the colon in a 10 year-old boy Paediatrica Indonesiana signet ring cell carcinoma SRCC colon familial polyposis ulcerative colitis |
| title | Signet ring cell carcinoma of the colon in a 10 year-old boy |
| title_full | Signet ring cell carcinoma of the colon in a 10 year-old boy |
| title_fullStr | Signet ring cell carcinoma of the colon in a 10 year-old boy |
| title_full_unstemmed | Signet ring cell carcinoma of the colon in a 10 year-old boy |
| title_short | Signet ring cell carcinoma of the colon in a 10 year-old boy |
| title_sort | signet ring cell carcinoma of the colon in a 10 year old boy |
| topic | signet ring cell carcinoma SRCC colon familial polyposis ulcerative colitis |
| url | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/898 |
| work_keys_str_mv | AT ireneirene signetringcellcarcinomaofthecolonina10yearoldboy AT ketutariawati signetringcellcarcinomaofthecolonina10yearoldboy |