Androgen Deprivation Therapy for Prostate Cancer: Focus on Cognitive Function and Mood
Prostate cancer is the second leading cause of cancer death in men in the United States. Androgen deprivation therapy (ADT) is currently the primary treatment for metastatic prostate cancer, and some studies have shown that the use of anti-androgen drugs is related to a reduction in cognitive functi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/60/1/77 |
| _version_ | 1827371481318817792 |
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| author | Allison B. Reiss Shelly Gulkarov Aaron Pinkhasov Katie M. Sheehan Ankita Srivastava Joshua De Leon Aaron E. Katz |
| author_facet | Allison B. Reiss Shelly Gulkarov Aaron Pinkhasov Katie M. Sheehan Ankita Srivastava Joshua De Leon Aaron E. Katz |
| author_sort | Allison B. Reiss |
| collection | DOAJ |
| description | Prostate cancer is the second leading cause of cancer death in men in the United States. Androgen deprivation therapy (ADT) is currently the primary treatment for metastatic prostate cancer, and some studies have shown that the use of anti-androgen drugs is related to a reduction in cognitive function, mood changes, diminished quality of life, dementia, and possibly Alzheimer’s disease. ADT has potential physiological effects such as a reduction in white matter integrity and a negative impact on hypothalamic functions due to the lowering of testosterone levels or the blockade of downstream androgen receptor signaling by first- and second-generation anti-androgen drugs. A comparative analysis of prostate cancer patients undergoing ADT and Alzheimer patients identified over 30 shared genes, illustrating common ground for the mechanistic underpinning of the symptomatology. The purpose of this review was to investigate the effects of ADT on cognitive function, mood, and quality of life, as well as to analyze the relationship between ADT and Alzheimer’s disease. The evaluation of prostate cancer patient cognitive ability via neurocognitive testing is described. Future studies should further explore the connection among cognitive deficits, mood disturbances, and the physiological changes that occur when hormonal balance is altered. |
| first_indexed | 2024-03-08T10:41:02Z |
| format | Article |
| id | doaj.art-1c62c4c2ef224689a621f8353dfeb7cb |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-08T10:41:02Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-1c62c4c2ef224689a621f8353dfeb7cb2024-01-26T17:35:15ZengMDPI AGMedicina1010-660X1648-91442023-12-016017710.3390/medicina60010077Androgen Deprivation Therapy for Prostate Cancer: Focus on Cognitive Function and MoodAllison B. Reiss0Shelly Gulkarov1Aaron Pinkhasov2Katie M. Sheehan3Ankita Srivastava4Joshua De Leon5Aaron E. Katz6Department of Medicine and Biomedical Research Institute, NYU Grossman Long Island School of Medicine, Mineola, NY 11501, USADepartment of Medicine and Biomedical Research Institute, NYU Grossman Long Island School of Medicine, Mineola, NY 11501, USADepartment of Psychiatry, NYU Grossman Long Island School of Medicine, Mineola, NY 11501, USADepartment of Medicine and Biomedical Research Institute, NYU Grossman Long Island School of Medicine, Mineola, NY 11501, USADepartment of Medicine and Biomedical Research Institute, NYU Grossman Long Island School of Medicine, Mineola, NY 11501, USADepartment of Medicine and Biomedical Research Institute, NYU Grossman Long Island School of Medicine, Mineola, NY 11501, USADepartment of Urology, NYU Grossman Long Island School of Medicine, Mineola, NY 11501, USAProstate cancer is the second leading cause of cancer death in men in the United States. Androgen deprivation therapy (ADT) is currently the primary treatment for metastatic prostate cancer, and some studies have shown that the use of anti-androgen drugs is related to a reduction in cognitive function, mood changes, diminished quality of life, dementia, and possibly Alzheimer’s disease. ADT has potential physiological effects such as a reduction in white matter integrity and a negative impact on hypothalamic functions due to the lowering of testosterone levels or the blockade of downstream androgen receptor signaling by first- and second-generation anti-androgen drugs. A comparative analysis of prostate cancer patients undergoing ADT and Alzheimer patients identified over 30 shared genes, illustrating common ground for the mechanistic underpinning of the symptomatology. The purpose of this review was to investigate the effects of ADT on cognitive function, mood, and quality of life, as well as to analyze the relationship between ADT and Alzheimer’s disease. The evaluation of prostate cancer patient cognitive ability via neurocognitive testing is described. Future studies should further explore the connection among cognitive deficits, mood disturbances, and the physiological changes that occur when hormonal balance is altered.https://www.mdpi.com/1648-9144/60/1/77androgen deprivation therapycognitive functionprostate cancerhormonal therapiesmanagement strategiestestosterone |
| spellingShingle | Allison B. Reiss Shelly Gulkarov Aaron Pinkhasov Katie M. Sheehan Ankita Srivastava Joshua De Leon Aaron E. Katz Androgen Deprivation Therapy for Prostate Cancer: Focus on Cognitive Function and Mood Medicina androgen deprivation therapy cognitive function prostate cancer hormonal therapies management strategies testosterone |
| title | Androgen Deprivation Therapy for Prostate Cancer: Focus on Cognitive Function and Mood |
| title_full | Androgen Deprivation Therapy for Prostate Cancer: Focus on Cognitive Function and Mood |
| title_fullStr | Androgen Deprivation Therapy for Prostate Cancer: Focus on Cognitive Function and Mood |
| title_full_unstemmed | Androgen Deprivation Therapy for Prostate Cancer: Focus on Cognitive Function and Mood |
| title_short | Androgen Deprivation Therapy for Prostate Cancer: Focus on Cognitive Function and Mood |
| title_sort | androgen deprivation therapy for prostate cancer focus on cognitive function and mood |
| topic | androgen deprivation therapy cognitive function prostate cancer hormonal therapies management strategies testosterone |
| url | https://www.mdpi.com/1648-9144/60/1/77 |
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