Genetic variation in IL-10 influences the progression of hepatitis B infection
Objectives: The outcomes of hepatitis B virus (HBV) infection vary substantially among affected individuals, providing evidence of the role of host genetic background in the susceptibility to HBV persistence and the dynamics of liver injury progression to cirrhosis and hepatocellular carcinoma (HCC)...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-07-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971220302976 |
| _version_ | 1818443521295646720 |
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| author | Magda Rybicka Anna Woziwodzka Alicja Sznarkowska Tomasz Romanowski Piotr Stalke Marcin Dręczewski Eloi R. Verrier Thomas F. Baumert Krzysztof Piotr Bielawski |
| author_facet | Magda Rybicka Anna Woziwodzka Alicja Sznarkowska Tomasz Romanowski Piotr Stalke Marcin Dręczewski Eloi R. Verrier Thomas F. Baumert Krzysztof Piotr Bielawski |
| author_sort | Magda Rybicka |
| collection | DOAJ |
| description | Objectives: The outcomes of hepatitis B virus (HBV) infection vary substantially among affected individuals, providing evidence of the role of host genetic background in the susceptibility to HBV persistence and the dynamics of liver injury progression to cirrhosis and hepatocellular carcinoma (HCC). Methods: Six single-nucleotide polymorphisms within the interleukin 10 gene (IL10) were genotyped by MALDI-TOF mass spectrometry in 857 patients with chronic HBV infection (CHB), 48 patients with resolved HBV infection, and 100 healthy volunteers. Associations of the selected polymorphisms with susceptibility to chronic HBV infection, liver injury progression, and outcomes were investigated. Results: IL10 −819T (rs1800871), −592A (rs1800872), and +504T (rs3024490) alleles were associated with treatment-induced hepatitis B surface antigen (HBsAg) seroclearance. Additionally, IL10 ATAC haplotype increased the chance of HBsAg loss and was significantly more frequent in patients with less liver injury. Moreover rs1800871TT, rs1518110TT, rs1800872AA, and rs3024490TT genotypes were identified as predictors of a lower FIB-4 score (<0.5). Conclusions: This study indicates that polymorphisms within the promoter region and intronic sequences of IL10 are associated with chronicity of hepatitis B and with HBV-induced liver damage. |
| first_indexed | 2024-12-14T19:01:22Z |
| format | Article |
| id | doaj.art-1c66a0150547457aac1af0b0cd251b49 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-14T19:01:22Z |
| publishDate | 2020-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-1c66a0150547457aac1af0b0cd251b492022-12-21T22:50:56ZengElsevierInternational Journal of Infectious Diseases1201-97122020-07-0196260265Genetic variation in IL-10 influences the progression of hepatitis B infectionMagda Rybicka0Anna Woziwodzka1Alicja Sznarkowska2Tomasz Romanowski3Piotr Stalke4Marcin Dręczewski5Eloi R. Verrier6Thomas F. Baumert7Krzysztof Piotr Bielawski8Department of Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Abrahama 58, 80-307 Gdansk, Poland; Corresponding authors.Department of Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Abrahama 58, 80-307 Gdansk, PolandDepartment of Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Abrahama 58, 80-307 Gdansk, Poland; International Centre for Cancer Vaccine Science, University of Gdansk, ul. Wita Stwosza 63, 80-308 Gdansk, PolandDepartment of Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Abrahama 58, 80-307 Gdansk, PolandDepartment of Infectious Diseases, Medical University of Gdansk, ul. Powstania Styczniowego 9b, 81-519 Gdynia, PolandDepartment of Infectious Diseases, Medical University of Gdansk, ul. Powstania Styczniowego 9b, 81-519 Gdynia, PolandUniversité de Strasbourg, Inserm, Institut de Recherche sur les Maladies Virales et Hépatiques UMR_S1110, F-67000 Strasbourg, FranceUniversité de Strasbourg, Inserm, Institut de Recherche sur les Maladies Virales et Hépatiques UMR_S1110, F-67000 Strasbourg, France; Pôle Hépato-Digestif, Institut Hospitalo-Universitaire, Hôpitaux Universitaires de Strasbourg, Strasbourg, FranceDepartment of Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Abrahama 58, 80-307 Gdansk, Poland; Corresponding authors.Objectives: The outcomes of hepatitis B virus (HBV) infection vary substantially among affected individuals, providing evidence of the role of host genetic background in the susceptibility to HBV persistence and the dynamics of liver injury progression to cirrhosis and hepatocellular carcinoma (HCC). Methods: Six single-nucleotide polymorphisms within the interleukin 10 gene (IL10) were genotyped by MALDI-TOF mass spectrometry in 857 patients with chronic HBV infection (CHB), 48 patients with resolved HBV infection, and 100 healthy volunteers. Associations of the selected polymorphisms with susceptibility to chronic HBV infection, liver injury progression, and outcomes were investigated. Results: IL10 −819T (rs1800871), −592A (rs1800872), and +504T (rs3024490) alleles were associated with treatment-induced hepatitis B surface antigen (HBsAg) seroclearance. Additionally, IL10 ATAC haplotype increased the chance of HBsAg loss and was significantly more frequent in patients with less liver injury. Moreover rs1800871TT, rs1518110TT, rs1800872AA, and rs3024490TT genotypes were identified as predictors of a lower FIB-4 score (<0.5). Conclusions: This study indicates that polymorphisms within the promoter region and intronic sequences of IL10 are associated with chronicity of hepatitis B and with HBV-induced liver damage.http://www.sciencedirect.com/science/article/pii/S1201971220302976HBVCirrhosisFibrosisIL10Single-nucleotide polymorphism |
| spellingShingle | Magda Rybicka Anna Woziwodzka Alicja Sznarkowska Tomasz Romanowski Piotr Stalke Marcin Dręczewski Eloi R. Verrier Thomas F. Baumert Krzysztof Piotr Bielawski Genetic variation in IL-10 influences the progression of hepatitis B infection International Journal of Infectious Diseases HBV Cirrhosis Fibrosis IL10 Single-nucleotide polymorphism |
| title | Genetic variation in IL-10 influences the progression of hepatitis B infection |
| title_full | Genetic variation in IL-10 influences the progression of hepatitis B infection |
| title_fullStr | Genetic variation in IL-10 influences the progression of hepatitis B infection |
| title_full_unstemmed | Genetic variation in IL-10 influences the progression of hepatitis B infection |
| title_short | Genetic variation in IL-10 influences the progression of hepatitis B infection |
| title_sort | genetic variation in il 10 influences the progression of hepatitis b infection |
| topic | HBV Cirrhosis Fibrosis IL10 Single-nucleotide polymorphism |
| url | http://www.sciencedirect.com/science/article/pii/S1201971220302976 |
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