Patient Survival and Cardiovascular Events after Kidney–Pancreas Transplantation: Comparison with Kidney Transplantation Alone in Uremic IDDM Patients
In diabetic patients cardiovascular morbidity and mortality is still a major problem. Our aim was to study the effect of kidney–pancreas transplantation on survival, cardiovascular events, and causes of death in diabetic type I uremic patients. Three hundred and thirty-three uremic IDDM patients wer...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2000-11-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.1177/096368970000900621 |
| _version_ | 1828909571945529344 |
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| author | Ennio La Rocca Paolo Fiorina Ettore Astorri Claudio Rossetti Giovanni Lucignani Ferruccio Fazio Daniela Giudici Renato Castoldi Giuseppe Bianchi Valerio Di Carlo Guido Pozza Antonio Secchi M.D. |
| author_facet | Ennio La Rocca Paolo Fiorina Ettore Astorri Claudio Rossetti Giovanni Lucignani Ferruccio Fazio Daniela Giudici Renato Castoldi Giuseppe Bianchi Valerio Di Carlo Guido Pozza Antonio Secchi M.D. |
| author_sort | Ennio La Rocca |
| collection | DOAJ |
| description | In diabetic patients cardiovascular morbidity and mortality is still a major problem. Our aim was to study the effect of kidney–pancreas transplantation on survival, cardiovascular events, and causes of death in diabetic type I uremic patients. Three hundred and thirty-three uremic IDDM patients were enrolled in our waiting list for kidney–pancreas transplantation: 107 underwent kidney–pancreas transplantation (KP), 34 underwent kidney transplantation alone (KA), whereas 192 patients remained on dialysis (WL). Actuarial survival and causes of death were recorded over a period of 7 years. Seven-year survival rate was 75% for the KP group, 63% for the KA group, and 37% for the WL group (p = 0.001). Cardiovascular death rate was 9.8% in the KP group, 17.6% in the KA group, and 18.1% in the WL group (KP vs. WL, p = 0.05). Rate of acute myocardial infarction in the KP group was lower than in the KA group (2.4% vs. 17.6%, p = 0.005) as well as rate of acute pulmonary edema (0.8% vs. 23.5%, p = 0.0001) and rate of hypertensive patients at 1 (40.9% vs. 85.0%, p = 0.0001) and at 2 years (57.6% vs. 80%, p = 0.03). Kidney–pancreas transplant helped to obtain euglycemia with positive effects on survival and cardiovascular events. |
| first_indexed | 2024-12-13T18:30:11Z |
| format | Article |
| id | doaj.art-1c66df2f56954488bad852a3685f3c52 |
| institution | Directory Open Access Journal |
| issn | 0963-6897 1555-3892 |
| language | English |
| last_indexed | 2024-12-13T18:30:11Z |
| publishDate | 2000-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj.art-1c66df2f56954488bad852a3685f3c522022-12-21T23:35:30ZengSAGE PublishingCell Transplantation0963-68971555-38922000-11-01910.1177/096368970000900621Patient Survival and Cardiovascular Events after Kidney–Pancreas Transplantation: Comparison with Kidney Transplantation Alone in Uremic IDDM PatientsEnnio La Rocca0Paolo Fiorina1Ettore Astorri2Claudio Rossetti3Giovanni Lucignani4Ferruccio Fazio5Daniela Giudici6Renato Castoldi7Giuseppe Bianchi8Valerio Di Carlo9Guido Pozza10Antonio Secchi M.D.11Departments of Internal Medicine, Via Olgettina 60, 20132 Milano, ItalyDepartments of Internal Medicine, Via Olgettina 60, 20132 Milano, ItalyDepartment of Cardiology, University of Parma, Via Gramsci 14, 43100 Parma, ItalyDepartments of Nuclear Medicine, Via Olgettina 60, 20132 Milano, ItalyDepartments of Nuclear Medicine, Via Olgettina 60, 20132 Milano, ItalyDepartments of Nuclear Medicine, Via Olgettina 60, 20132 Milano, ItalyDepartments of Anesthesiology, Via Olgettina 60, 20132 Milano, ItalyDepartments of General Surgery, Via Olgettina 60, 20132 Milano, ItalyDepartments of Nephrology, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milano, ItalyDepartments of General Surgery, Via Olgettina 60, 20132 Milano, ItalyDepartments of Internal Medicine, Via Olgettina 60, 20132 Milano, ItalyDepartments of Internal Medicine, Via Olgettina 60, 20132 Milano, ItalyIn diabetic patients cardiovascular morbidity and mortality is still a major problem. Our aim was to study the effect of kidney–pancreas transplantation on survival, cardiovascular events, and causes of death in diabetic type I uremic patients. Three hundred and thirty-three uremic IDDM patients were enrolled in our waiting list for kidney–pancreas transplantation: 107 underwent kidney–pancreas transplantation (KP), 34 underwent kidney transplantation alone (KA), whereas 192 patients remained on dialysis (WL). Actuarial survival and causes of death were recorded over a period of 7 years. Seven-year survival rate was 75% for the KP group, 63% for the KA group, and 37% for the WL group (p = 0.001). Cardiovascular death rate was 9.8% in the KP group, 17.6% in the KA group, and 18.1% in the WL group (KP vs. WL, p = 0.05). Rate of acute myocardial infarction in the KP group was lower than in the KA group (2.4% vs. 17.6%, p = 0.005) as well as rate of acute pulmonary edema (0.8% vs. 23.5%, p = 0.0001) and rate of hypertensive patients at 1 (40.9% vs. 85.0%, p = 0.0001) and at 2 years (57.6% vs. 80%, p = 0.03). Kidney–pancreas transplant helped to obtain euglycemia with positive effects on survival and cardiovascular events.https://doi.org/10.1177/096368970000900621 |
| spellingShingle | Ennio La Rocca Paolo Fiorina Ettore Astorri Claudio Rossetti Giovanni Lucignani Ferruccio Fazio Daniela Giudici Renato Castoldi Giuseppe Bianchi Valerio Di Carlo Guido Pozza Antonio Secchi M.D. Patient Survival and Cardiovascular Events after Kidney–Pancreas Transplantation: Comparison with Kidney Transplantation Alone in Uremic IDDM Patients Cell Transplantation |
| title | Patient Survival and Cardiovascular Events after Kidney–Pancreas Transplantation: Comparison with Kidney Transplantation Alone in Uremic IDDM Patients |
| title_full | Patient Survival and Cardiovascular Events after Kidney–Pancreas Transplantation: Comparison with Kidney Transplantation Alone in Uremic IDDM Patients |
| title_fullStr | Patient Survival and Cardiovascular Events after Kidney–Pancreas Transplantation: Comparison with Kidney Transplantation Alone in Uremic IDDM Patients |
| title_full_unstemmed | Patient Survival and Cardiovascular Events after Kidney–Pancreas Transplantation: Comparison with Kidney Transplantation Alone in Uremic IDDM Patients |
| title_short | Patient Survival and Cardiovascular Events after Kidney–Pancreas Transplantation: Comparison with Kidney Transplantation Alone in Uremic IDDM Patients |
| title_sort | patient survival and cardiovascular events after kidney pancreas transplantation comparison with kidney transplantation alone in uremic iddm patients |
| url | https://doi.org/10.1177/096368970000900621 |
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